KEGG ORTHOLOGY: K01229

ORTHOLOGY: K01229

Entry

K01229                      KO

Symbol

LCT

Name

lactase-phlorizin hydrolase [EC:3.2.1.108 3.2.1.62]

Pathway

map00052

Galactose metabolism

map01100

Metabolic pathways

map04973

Carbohydrate digestion and absorption

Reaction

R01678

lactose galactohydrolase

R06114

Disease

H00116

Congenital lactase deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00052 Galactose metabolism
    K01229  LCT; lactase-phlorizin hydrolase
09150 Organismal Systems
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    K01229  LCT; lactase-phlorizin hydrolase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K01229  LCT; lactase-phlorizin hydrolase
Enzymes [BR:ko01000]
3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.62  glycosylceramidase
     K01229  LCT; lactase-phlorizin hydrolase
    3.2.1.108  lactase
     K01229  LCT; lactase-phlorizin hydrolase
Chaperones and folding catalysts [BR:ko03110]
Intramolecular chaperones
  Others
   K01229  LCT; lactase-phlorizin hydrolase

Other DBs

GO:	0000016 0017042

Genes

HSA:

3938(LCT)

PTR:	459633(LCT)

PPS:	100993974(LCT)

GGO:	101136936(LCT)

PON:	100450303(LCT)

PPYG:

129031450(LCT)

NLE:	100602088(LCT)

HMH:	116462849(LCT)

SSYN:

129472407(LCT)

MCC:	707761(LCT)

MCF:	102141036(LCT)

MTHB:

126932258

MNI:	105492565(LCT)

CSAB:

103216991(LCT)

CATY:

105590352(LCT)

PANU:

101022382(LCT)

TGE:	112636379(LCT)

MLEU:

105532195(LCT)

RRO:	104665436(LCT)

RBB:	108539586(LCT)

TFN:	117095069(LCT)

PTEH:

111527488(LCT)

CANG:

105508813(LCT)

CJC:	100408648(LCT)

SBQ:	101044226(LCT)

CIMI:

108293356(LCT)

ANAN:

105734033(LCT)

CSYR:

103263113(LCT)

MMUR:

105857603(LCT)

LCAT:

123643641(LCT)

ERUF:

138386650(LCT)

PCOQ:

105815373(LCT)

OGA:	100944107(LCT)

MMU:	226413(Lct)

MCAL:

110304188(Lct)

MPAH:

110322545(Lct)

RNO:	116569(Lct)

MCOC:

116098602(Lct)

ANU:	117716486(Lct)

ASYL:

127697811(Lct)

MUN:	110555417(Lct)

CGE:	100766856(Lct)

MAUA:

101828124(Lct)

PROB:

127236450(Lct)

PLEU:

114696961(Lct)

PMAV:

102917293(Lct)

MORG:

121446300 121446324 121446359

MFOT:

126504990

AAMP:

119827729 119827814 119827830

CNL:	130874804 130874809 130874817

NGI:	103734619(Lct)

HGL:	101697396(Lct)

CPOC:

100732160(Lct)

DORD:

105996629(Lct)

DSP:	122110822(Lct)

DMER:

138838957(Lct)

PLOP:

125350733(Lct)

NCAR:

124980608

MMMA:

107136606(Lct)

ITI:	101957467(Lct)

OCU:	100009256(LPH) 100352497 100353264

OPI:	101519618 101519868 101520351

OCZ:	121150566 121150568 121150570

TUP:	102470311(LCT)

GVR:	103610021(LCT)

CFA:	483898(LCT)

CLUD:

112649763(LCT)

VVP:	112932617(LCT)

VLG:	121481866(LCT)

NPO:	129503765(LCT)

AML:	100484153(LCT)

UMR:	103667712(LCT)

UAH:	113263420(LCT)

UAR:	123782596(LCT)

ELK:

111143551

LLV:

125095933

MPUF:

101676191(LCT)

MNP:	132013924(LCT)

MLK:	131826962(LCT)

NVS:	122902701(LCT)

ORO:	101373825(LCT)

EJU:	114207344(LCT)

ZCA:	113920630(LCT)

MLX:	118012500(LCT)

NSU:	110585741(LCT)

LWW:	102749114(LCT)

FCA:	101092452(LCT)

PYU:	121030495(LCT)

PCOO:

112865772(LCT)

PBG:	122479372(LCT)

PVIV:

125173776(LCT)

LRUF:

124516018

LGF:	123598860(LCT)

AJU:

106969449

PTG:	102949288(LCT)

PPAD:

109270343(LCT)

PUC:

125911425

PLEZ:

122225865(LCT)

HHV:	120230375(LCT)

BTA:	514332(LCT)

BOM:	102279578(LCT)

BIU:	109568203(LCT)

BBUB:

102410227(LCT)

BKE:	129646494(LCT)

BBIS:

104998486(LCT)

CHX:	102170472(LCT)

OAS:	101104042(LCT)

BTAX:

128043741(LCT)

CSUM:

138077090(LCT)

ODA:	120854489(LCT)

CCAD:

122453560(LCT)

MREE:

136163409(LCT)

OVR:	110128453(LCT)

MBEZ:

129537793(LCT)

SSC:	100625807(LCT) 100625897

CFR:	102513047(LCT)

CBAI:

105083393(LCT)

CDK:	105092305(LCT)

VPC:	102532468(LCT)

BACU:

103003658(LCT)

BMUS:

118897845(LCT)

LVE:	103074579(LCT)

OOR:	101270599(LCT)

LALB:

132522401(LCT)

GMF:	115867074(LCT)

DDP:	132428665(LCT)

DLE:	111172712(LCT)

PCAD:

102988992(LCT)

PSIU:

116756492(LCT)

PPHC:

136125355(LCT)

NASI:

112412418(LCT)

ECB:	100055369(LCT)

EPZ:	103548925(LCT)

EAI:	106836543(LCT)

MYB:	102246527(LCT)

MYD:	102761793(LCT)

MMYO:

118662079(LCT)

MLF:	102430551(LCT)

MDT:	132238677(LCT)

MYUM:

139015344(LCT)

PKL:	118709739(LCT)

EFUS:

103287808(LCT)

MNA:	107531139(LCT)

DRO:	112313063(LCT)

SHON:

118974532(LCT)

AJM:	119040600(LCT)

PDIC:

114495149(LCT)

PHAS:

123810272(LCT)

MMF:	118625706(LCT)

PPAM:

129061964(LCT)

HAI:	109392715(LCT)

RFQ:	117025498(LCT)

PALE:

102887366(LCT)

PGIG:

120611943(LCT)

PVP:	105288339(LCT)

RAY:	107511200(LCT)

MJV:	108405363(LCT)

TOD:	119255787(LCT)

SARA:

101545875(LCT)

SFUM:

130026852(LCT)

SETR:

126009216(LCT)

LAV:	100661599(LCT)

TMU:

101348169

ETF:	101659833(LCT)

DNM:	101441621(LCT)

MDO:	100016393(LCT)

GAS:	123241493(LCT)

SHR:	100933904(LCT)

AFZ:

127554360

PCW:	110223786(LCT)

TVP:	118837034 118839566(LCT)

PBRV:

138146120(LCT)

MLAO:

141505814(LCT)

OAA:	100084941(LCT)

TACU:

119932068(LCT)

GGA:	424294(LCT)

PCOC:

116227271(LCT)

MGP:	100540699(LCT)

CJO:	107316868(LCT)

TPAI:

128076739 128076758(LCT)

LMUT:

125696719(LCT)

NMEL:

110399364(LCT)

APLA:

101799746(LCT)

AACU:

137858915(LCT)

ACYG:

106039329(LCT)

CATA:

118252584(LCT)

AFUL:

116490699(LCT)

TGU:	100229941(LCT)

LSR:	110480639(LCT)

SCAN:

103814626(LCT)

PMOA:

120501755(LCT)

OTC:	121337155(LCT)

PRUF:

121356606(LCT)

ATRC:

139593910(LCT)

GFR:	102041259(LCT)

FAB:	101814034(LCT)

OMA:	130255396(LCT)

PHI:	102100057(LCT)

PMAJ:

107207677(LCT)

CCAE:

111932317(LCT)

CCW:	104694217(LCT)

CBRC:

103619703(LCT)

ACOE:

138113206(LCT)

ETL:	114057697(LCT)

ZAB:	102069527(LCT)

ZLE:	135450222(LCT)

ACHL:

103797517(LCT)

SVG:	106849901(LCT)

MMEA:

130573792(LCT)

HRT:	120755091(LCT)

SATI:

136363866(LCT)

CCIC:

134047101(LCT)

FPG:	101921531(LCT)

FCH:	102058755(LCT)

CCRI:

104157657(LCT)

NNT:	104411659(LCT)

SHAB:

115608691(LCT)

ACUN:

113482159(LCT)

SURA:

141945486(LCT)

TALA:

104368387(LCT)

ACHC:

115342953(LCT)

HALD:

104323141(LCT)

HLE:	104836526(LCT)

AGEN:

126042537

HHAR:

128143999(LCT)

BBUT:

142031449(LCT)

GCL:

127018545

CSTI:

104559163(LCT)

LDI:	104349434(LCT)

MNB:	103775982(LCT)

DPUB:

104296940(LCT)

PPUS:

135182040(LCT)

AVIT:

104277503(LCT)

BRHI:

104488766(LCT)

EGZ:	104129535(LCT)

NNI:	104009760(LCT)

PCRI:

104026793(LCT)

PCAO:

104053764(LCT)

PARX:

142057229(LCT)

PADL:

103912627(LCT)

AFOR:

103899524(LCT)

FGA:	104076580(LCT)

CBOR:

142083393(LCT)

GSTE:

104255215(LCT)

CBOY:

140657361(LCT)

MAME:

142414656(LCT)

CLV:	102086420(LCT)

CNIC:

135990308(LCT)

MUI:	104545327(LCT)

PGUU:

104467528(LCT)

PLET:

104616147(LCT)

EHS:	104506311(LCT)

CMAC:

104479709(LCT)

CUCA:

104065226(LCT)

BREG:

104640666(LCT)

GAME:

129207983(LCT)

OHA:	104333255(LCT)

ACAR:

104532723(LCT)

CPEA:

104391143(LCT)

CVF:	104287949(LCT)

RTD:	128912463(LCT)

CRID:

134519022(LCT)

LMIC:

141746838(LCT)

NARQ:

141463073(LCT)

AAM:	106498455(LCT)

AROW:

112977064(LCT)

NPD:	112948593(LCT)

TGT:	104565650(LCT)

DNE:	112988323(LCT)

SCAM:

104145714(LCT)

ASN:	102370133(LCT)

AMJ:	102576031(LCT)

CPOO:

109323207(LCT)

GGN:	109301357(LCT)

PSS:	102456860(LCT)

CIZ:	142016771(LCT)

CMY:	102946778(LCT)

CCAY:

125645164(LCT)

LKP:	140895507(LCT)

NDS:	141995558(LCT)

DCC:	119863237(LCT)

CPIC:

101933763(LCT)

TST:	117885118(LCT)

CABI:

116826106(LCT)

MRV:	120374328(LCT)

ACS:	103279188(lct)

ASAO:

132761769(LCT)

PVT:	110071879(LCT)

SUND:

121925981(LCT)

PBI:	103054678(LCT)

PMUR:

107284386(LCT)

CTIG:

120307504(LCT)

TSR:	106540054(LCT)

PGUT:

117669655(LCT)

PCAE:

139310207(LCT)

APRI:

131203696(LCT)

PTEX:

113445465(LCT)

NSS:	113410676(LCT)

VKO:	123027553(LCT)

PMUA:

114604625(LCT)

PRAF:

128422073(LCT)

ZVI:	118092494(LCT)

HCG:	128328212(LCT)

GJA:	107115411(LCT)

STOW:

125426237(LCT)

EMC:	129324486(LCT)

XLA:	100127248(lct.1.L) 100127291(lct.2.L)

XTR:	100145766(lct.2) 101732850

NPR:	108791336 108791337

RTEM:

120944145 120944146

ACAT:

141147131 141147132 141147133

PADS:

140335472 140335473

BBUF:

121008829(LCT) 121008830

BGAR:

122944682 122944685

DTC:

141049280

PWL:	138285309(LCT)

MUO:	115475128(LCT)

GSH:	117361638(LCT)

DRE:	559107 796436(lct)

SRX:	107739717 107741586

SANH:

107688954 107704822

SGH:	107601359 107601360

CCAR:

CAUA:

CGIB:

PTET:

LROH:

GRF:	141340194 141341093 141341094 141341095

OMC:	131546619 131546620 131546621 131546622 131546623

PPRM:

120485547 120487230

RKG:	130084491 130097216 130099787

MAMB:

125245778 125245780 125270691

CIDE:

CERY:

MASI:

TROS:

TDW:	130427662 130427691

MANU:

PDAB:

IPU:

IFU:

PHYP:

113525948(lct)

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:	113577223(lct)

CHAR:

105907898 105907899

SPIL:

134077965 134077966 134077968 134077969 134077970

ASAD:

121700407 121700418

TRU:	101076621 115246505

TFS:	130529775 130529793

LCO:	104939725(lct)

NCC:	104954911(lct)

TBEN:

117485876 117485937

CGOB:

115026493(lct)

PGEO:

117466341

GACU:

117541578 117541579

EMAC:

134867246 134867455

ELY:	117248075 117251770

EFO:	125899187 125899188

PLEP:

121949084 121949085

SLUC:

116044576 116044580

ECRA:

117953249

ESP:	116687473(lct)

PFLV:

114563686 114564430

GAT:	120834464 120834490

PPUG:

119229302

AFB:	129104896 129104897

CLUM:

PSWI:

CANA:

CVE:

MSAM:

SCHU:

EARM:

CUD:	121522156 121522288 121522602

SPUL:

138592224 138592665

LMIX:

132987043 132987517

HTC:	141808650 141808651

ALAT:

119025751 119026172

ASTR:

137605455 137605458

PKLU:

139208104 139208196

MZE:	101465201 101465483

ONL:	100703330 100703603 100703875 102080755

OAU:	116324944 116324945 116324946 116333422

OLA:	101171223(lct)

OML:	112155270 112155271 112155272

CSAI:

133446121

XMA:	102216752 102217013 102223171(lct)

XCO:	114147565 114147571 114147572

XHE:	116722850 116722851 116723643(lct) 116723644

PRET:

103461729

PFOR:

103152094(lct) 103153521

PLAI:

106942509 106945899 106945900

PMEI:

106908439(lct) 106920698

GAF:	122840135 122840136

PPRL:

129374492 129374496

CVG:	107091021(lct) 107091024

CTUL:

119796496 119796544

GMU:	124870853 124870854

NFU:	107389384(lct)

ALIM:

106522267(lct)

NWH:

AOCE:

EJA:

BFRE:

MCEP:

125017507 125017508 125017509 125017510 125017511 125017512 125017513

CSEM:

103392433(lct)

POV:	109631110 109631322

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111218818 111218819

SLAL:

111667436 111667458

XGL:

120801628

HCQ:	109515508(lct)

SBIA:

PEE:

PTAO:

ENY:

MALB:

109966332(lct)

BSPL:

114847775

SJO:	128368328 128368329 128368330

SSCO:

133993294 133993295 133993296

TTY:	137192420 137192421

GMH:	115533056(lct)

SASA:

106586119(lct)

STRU:

115160641(lct)

OTW:

112235127

OMY:

110519997

OGO:

124043772

ONE:	115107792(lct)

OKI:	109904123(lct)

OKE:

118367180

OMM:

135519857

OCLA:

139385603

SALP:

111973682(lct)

SNH:

120057744

SFON:

129821384

CCLU:

121536644

ELS:	105005862(lct)

OEP:

134016953

SFM:	108928209(lct)

PKI:	111842887(lct)

AANG:

118222690

AROT:

135250487

CCOG:

133123494

LOC:	102691495(lct)

PSPA:

121323070

ARUT:

117407121

PSEX:

120530640

LCM:	102361997(LCT)

CMK:

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

PMRN:

116937990(LCT)

LRJ:	133346175(LCT) 133356187

BFO:	118408130 118413613

BBEL:

CIN:

SCLV:

CLEP:

SPU:

LPIC:

129264315 129264855 129264857 129265348 129265957 129268212 129268215

LVG:	121418045 121418723 121418967

AJJ:

139970550

APLC:

110979240

AFIL:

140151705 140151999 140152384 140152385

SKO:

100377377

PFLL:

139132545 139147818 139147819 139148252 139149291 139149297

LGI:	LOTGIDRAFT_174304

PVUL:

126824396 126824536

PCAN:

112561449

LSAX:

138965940 138967580 138973699 138976880

BARL:

143274608 143288088 143288403 143294587

BGT:	106067751 106069349 106069463

HRF:	124113779 124113782 124151882

HRJ:	124256256 124256662 124256664 124266902

HASI:

137274310 137277882 137277894 137295821

HCRA:

139454886 139472250

CANU:

128187165 128188756

CVN:	111136393 111136395

OED:	125680285 125680292

MYI:

110453818

PMAX:

117332095

AIRR:

138331161 138331283

YBA:	132544937 132544951

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

LJP:	135470749 135477119

DGT:

TWL:

CJF:

Reference

PMID:19034520

Authors

Ingram CJ, Mulcare CA, Itan Y, Thomas MG, Swallow DM

Title

Lactose digestion and the evolutionary genetics of lactase persistence.

Journal

Hum Genet 124:579-91 (2009)
DOI:10.1007/s00439-008-0593-6

Reference

PMID:1902057

Authors

Boll W, Wagner P, Mantei N

Title

Structure of the chromosomal gene and cDNAs coding for lactase-phlorizin hydrolase in humans with adult-type hypolactasia or persistence of lactase.

Journal

Am J Hum Genet 48:889-902 (1991)

Sequence

[hsa:3938]

LinkDB

DBGET integrated database retrieval system