KEGG ORTHOLOGY: K04352

ORTHOLOGY: K04352

Entry

K04352                      KO

Symbol

RASA1, RASGAP

Name

Ras GTPase-activating protein 1

Pathway

map04010

MAPK signaling pathway

map04013

MAPK signaling pathway - fly

map04014

Ras signaling pathway

map04360

Axon guidance

Disease

H00039

Basal cell carcinoma

H00532

Parkes Weber syndrome

H02043

Capillary malformation-arteriovenous malformation

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04352  RASA1, RASGAP; Ras GTPase-activating protein 1
   04013 MAPK signaling pathway - fly
    K04352  RASA1, RASGAP; Ras GTPase-activating protein 1
   04014 Ras signaling pathway
    K04352  RASA1, RASGAP; Ras GTPase-activating protein 1
09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K04352  RASA1, RASGAP; Ras GTPase-activating protein 1

Other DBs

GO:

0005096

Genes

HSA:	5921(RASA1)

PTR:	461762(RASA1)

PPS:	100978056(RASA1)

GGO:	101135999(RASA1)

PON:	100172162(RASA1)

PPYG:

129037541(RASA1)

NLE:	100582242(RASA1)

HMH:	116471023(RASA1)

SSYN:

129457636(RASA1)

MCC:	694085(RASA1)

MCF:	102130897(RASA1)

MTHB:

126957382

MNI:	105475018(RASA1)

CSAB:

103224220(RASA1)

CATY:

105599108(RASA1)

PANU:

101015118(RASA1)

TGE:	112625711(RASA1)

MLEU:

105538202(RASA1)

RRO:	104655278(RASA1)

RBB:	108541147(RASA1)

TFN:	117064940(RASA1)

PTEH:

111544466(RASA1)

CANG:

105513383(RASA1)

CJC:	100415187(RASA1)

SBQ:	101032122(RASA1)

CIMI:

108288911(RASA1)

ANAN:

105734659(RASA1)

CSYR:

103255853(RASA1)

MMUR:

105880427(RASA1)

LCAT:

123648443(RASA1)

PCOQ:

105810718(RASA1)

OGA:	100956457(RASA1)

MMU:	218397(Rasa1)

MCAL:

110308133(Rasa1)

MPAH:

110328850(Rasa1)

RNO:	25676(Rasa1)

MCOC:

116083408(Rasa1)

ANU:	117700410(Rasa1)

ASYL:

127667029(Rasa1)

MUN:	110564462(Rasa1)

CGE:	100762440(Rasa1)

MAUA:

101834599(Rasa1)

PROB:

127221044(Rasa1)

PLEU:

114710510(Rasa1)

MORG:

121455910(Rasa1)

MFOT:

126487165

AAMP:

119809233(Rasa1)

NGI:	103739115(Rasa1)

HGL:	101713771(Rasa1)

CPOC:

100726441(Rasa1)

CCAN:

109694624(Rasa1)

DORD:

105985378(Rasa1)

DSP:	122117115(Rasa1)

PLOP:

125340110(Rasa1)

NCAR:

124987003

MMMA:

107152337(Rasa1)

ITI:	101961289(Rasa1)

OCU:

100343398

OPI:	101534863(RASA1)

TUP:	102503100(RASA1)

GVR:	103593622(RASA1)

CFA:	479158(RASA1)

CLUD:

112653254(RASA1)

VVP:	112915578(RASA1)

VLG:	121488649(RASA1)

NPO:	129521081(RASA1)

AML:	100465811(RASA1)

UMR:	103672177(RASA1)

UAH:	113255128(RASA1)

UAR:	123791499(RASA1)

ELK:

111148287

LLV:

125100932

MPUF:

101692458(RASA1)

MNP:	132028789(RASA1)

MLK:	131832433(RASA1)

NVS:	122917736(RASA1)

ORO:	101372560(RASA1)

EJU:	114217622(RASA1)

ZCA:	113929419(RASA1)

MLX:	118016971(RASA1)

NSU:	110590962(RASA1)

LWW:	102731109(RASA1)

FCA:	101095151(RASA1)

PYU:	121013519(RASA1)

PCOO:

112861428(RASA1)

PBG:	122490769(RASA1)

PVIV:

125147761(RASA1)

LRUF:

124518790

LGF:	123608002(RASA1)

AJU:

106978599

PTG:	102959932(RASA1)

PPAD:

109274891(RASA1)

PUC:

125935809

PLEZ:

122222429(RASA1)

HHV:	120224108(RASA1)

BTA:	282032(RASA1)

BOM:	102266032(RASA1)

BIU:	109562314(RASA1)

BBUB:

102416344(RASA1)

BBIS:

104982501(RASA1)

CHX:	102170782(RASA1)

OAS:	101119216(RASA1)

BTAX:

128051785(RASA1)

CSUM:

138086141(RASA1)

ODA:	120863292(RASA1)

CCAD:

122439554(RASA1)

MREE:

136143839(RASA1)

OVR:	110142262(RASA1)

MBEZ:

129558112(RASA1)

SSC:	100627579(RASA1)

CFR:	102506564(RASA1)

CBAI:

105074880(RASA1)

CDK:	105099632(RASA1)

VPC:	102534377(RASA1)

BACU:

102998210(RASA1)

BMUS:

118893511(RASA1)

LVE:	103070068(RASA1)

OOR:	101275044(RASA1)

LALB:

132516935(RASA1)

DLE:	111184598(RASA1)

PCAD:

102991867(RASA1)

PSIU:

116750787(RASA1)

NASI:

112392565(RASA1)

ECB:	100073242(RASA1)

EPZ:	103545018(RASA1)

EAI:	106841206(RASA1)

MYB:	102264248(RASA1)

MYD:	102760886(RASA1)

MMYO:

118655739(RASA1)

MLF:	102443135(RASA1)

MDT:	132233445(RASA1)

MYUM:

139008736(RASA1)

PKL:	118703913(RASA1)

EFUS:

103305361(RASA1)

MNA:	107535058(RASA1)

DRO:	112307544(RASA1)

SHON:

118977386(RASA1)

AJM:	119052750(RASA1)

PDIC:

114509984(RASA1)

PHAS:

123824870(RASA1)

MMF:	118642904(RASA1)

PPAM:

129074666(RASA1)

HAI:	109381973(RASA1)

RFQ:	117024549(RASA1)

PALE:

102883307(RASA1)

PGIG:

120612507(RASA1)

PVP:	105304708(RASA1)

RAY:	107499531(RASA1)

MJV:	108394495(RASA1)

TOD:	119260518(RASA1)

SARA:

101551317(RASA1)

SFUM:

130021686(RASA1)

SETR:

126001889(RASA1)

LAV:	100670884(RASA1)

TMU:

101359278

ETF:	101638369(RASA1)

DNM:	101445868(RASA1)

MDO:	100013724(RASA1)

GAS:	123236490(RASA1)

SHR:	100933624(RASA1)

AFZ:

127559393

PCW:	110222845(RASA1)

TVP:	118829518(RASA1)

PBRV:

138158820(RASA1)

OAA:	100080153(RASA1)

TACU:

119944812(RASA1)

GGA:	427327(RASA1)

PCOC:

116239740(RASA1)

MGP:	104915268(RASA1)

CJO:	107306505(RASA1)

TPAI:

128089273(RASA1)

LMUT:

125686409 125687160(RASA1)

NMEL:

110389509(RASA1)

APLA:

101801452(RASA1) 101805096

ACYG:

106048991(RASA1)

CATA:

118256325(RASA1)

AFUL:

116500446(RASA1) 116501401

TGU:	100226598(RASA1) 116806888

LSR:	110479149(RASA1)

SCAN:

103821051(RASA1) 103824743

PMOA:

120499637(RASA1)

OTC:	121332559(RASA1)

PRUF:

121358011 121359715

ATRC:

139599006 139600465(RASA1)

GFR:	102035204(RASA1) 102040076

FAB:	101809092(RASA1)

OMA:	130264769(RASA1)

PHI:	102100827(RASA1)

PMAJ:

107215992(RASA1)

CCAE:

111941591(RASA1)

CCW:	104693216(RASA1)

CBRC:

103613064(RASA1) 103621501

ACOE:

138102685 138103683(RASA1)

ETL:	114069721 114073765(RASA1)

ZAB:	102070141(RASA1)

ZLE:	135460159(RASA1) 135460376

ACHL:

103807589(RASA1)

SVG:	106863283(RASA1)

MMEA:

130582900(RASA1)

HRT:	120764944 120765031(RASA1)

SATI:

136373395 136374131(RASA1)

CCIC:

134057043(RASA1)

FPG:	101915808(RASA1)

FCH:	102046190(RASA1)

CCRI:

104165790(RASA1)

NNT:	104408630(RASA1)

SHAB:

115600675(RASA1) 115619024

ACUN:

113490284(RASA1)

TALA:

104367979(RASA1)

ACHC:

115336501(RASA1) 121232770

HALD:

104320501(RASA1)

HLE:	104838374(RASA1)

AGEN:

126035245 126036578

HHAR:

128136192 128136375(RASA1)

GCL:	127027445 127029121

CSTI:

104563576(RASA1)

LDI:	104346586(RASA1)

MNB:	103778453(RASA1)

DPUB:

104310160(RASA1)

PPUS:

135173700(RASA1) 135173800

AVIT:

104268010(RASA1)

BRHI:

104490547(RASA1)

EGZ:	104128363(RASA1)

NNI:	104011928(RASA1)

PCAO:

104048039(RASA1)

PADL:

103924460(RASA1)

AFOR:

103906386(RASA1)

FGA:	104083041(RASA1)

GSTE:

104259734(RASA1)

CLV:	102089229(RASA1)

MUI:	104533713(RASA1)

PGUU:

104468649(RASA1)

PLET:

104627128(RASA1)

CMAC:

104486692

CUCA:

104061084(RASA1) 128850269

TEO:	104380987(RASA1)

BREG:

104633691(RASA1)

OHA:	104330403(RASA1)

ACAR:

104518607(RASA1)

CPEA:

104387961 104388911(RASA1)

CVF:	104288121(RASA1) 104295611

RTD:	128902080 128902148(RASA1)

CRID:

134508806(RASA1)

AROW:

112966832(RASA1)

NPD:	112945604(RASA1)

TGT:	104568517 104578233(RASA1)

DNE:	112992043(RASA1)

SCAM:

104150537(RASA1)

ASN:	102382477(RASA1)

AMJ:	102577063(RASA1)

CPOO:

109307696(RASA1)

GGN:	109298049(RASA1)

PSS:	102444162(RASA1)

CMY:	102944043(RASA1)

CCAY:

125637465(RASA1)

DCC:	119855483(RASA1)

CPIC:

101950575(RASA1)

TST:	117879624(RASA1)

CABI:

116826152(RASA1)

MRV:	120407784(RASA1)

ACS:	100556494(rasa1)

ASAO:

132767131(RASA1)

PVT:	110073983(RASA1)

SUND:

121921498(RASA1)

PBI:	103062402(RASA1)

PMUR:

107302942(RASA1)

CTIG:

120315365(RASA1)

TSR:	106554534(RASA1)

PGUT:

117679366(RASA1)

APRI:

131190936(RASA1)

PTEX:

113445028(RASA1)

NSS:	113414139(RASA1)

VKO:	123031220(RASA1)

PMUA:

114606766(RASA1)

PRAF:

128423767(RASA1)

ZVI:	118076691(RASA1)

HCG:	128345853(RASA1)

GJA:	107107221(RASA1)

STOW:

125436445(RASA1)

EMC:	129334382(RASA1)

XLA:	106557444(rasa1.L) 108707239(rasa1.S)

XTR:	100135092(rasa1)

NPR:	108800427(RASA1)

RTEM:

120930629(RASA1)

BBUF:

120992505(RASA1)

PWL:	138285208(RASA1)

MUO:	115463127(RASA1)

GSH:	117349269(RASA1)

DRE:	100002155(rasa1a) 564822(rasa1b)

SRX:	107720192 107741680 107753180 107758634

SANH:

107660974 107669512 107689448

SGH:	107553923 107557440(rasa1) 107588970 107602079

CCAR:

109059668 109081532 109081536(rasa1a) 109097453(rasa1b)

CAUA:

113049055 113054616 113079136 113110275

CGIB:

127957782 127966043 127999356 128020746

PTET:

122333766(rasa1b) 122345178(rasa1a)

LROH:

127165032(rasa1a) 127172464(rasa1b)

OMC:	131540535(rasa1a) 131548392(rasa1b)

PPRM:

120482852 120482856 120492632 120492633

RKG:	130069510(rasa1a)

MAMB:

125262369(rasa1b) 125267468(rasa1a)

CIDE:

127512021 127521096

CERY:

137028569(rasa1b) 137033559(rasa1a)

MASI:

127419433 127432637 127432820 127434060

TROS:

130564253(rasa1a)

MANU:

129440675(rasa1a)

PDAB:

135744746 135748872

IPU:	108255829(rasa1a)

IFU:	128625575(rasa1a)

PHYP:

113536994(rasa1)

SMEO:

124380433(rasa1a)

TFD:	113637621(rasa1a)

TVC:	132855345(rasa1a)

CGAR:

128509027(rasa1a)

NGRA:

132872329(rasa1a)

TRN:	134335044(rasa1a)

AMEX:

103035872(rasa1a)

CMAO:

118825294(rasa1b) 118826842(rasa1a)

EEE:	113572895(rasa1)

CHAR:

105890812(rasa1b) 105901256(rasa1a)

SPIL:

134089001(rasa1a) 134100897(rasa1b)

TRU:	101069465(rasa1)

TFS:	130525385(rasa1a)

TNG:	GSTEN00028720G001

LCO:	104926811(rasa1)

NCC:

104955190

TBEN:

117472626

CGOB:

115013216(rasa1)

PGEO:

117452043

GACU:

117562464(rasa1a)

EMAC:

134873656

ELY:	117252406(rasa1a)

EFO:

125889970

PLEP:

121943963(rasa1a)

SLUC:

116056595(rasa1a)

ECRA:

117945189

ESP:	116689286(rasa1)

PFLV:

114555174(rasa1)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

130197325(rasa1a)

CANA:

137805063

CVE:	137866886(rasa1a)

MSAM:

119891428(rasa1a)

SCHU:

122876046

CUD:	121509611(rasa1a)

SPUL:

138609920

LMIX:

132974101(rasa1a)

ALAT:

119019347(rasa1a)

ASTR:

137592255

MZE:	101473967(rasa1)

ONL:	100707127(rasa1)

OAU:

116317445

OLA:	101165895(rasa1)

OML:	112148354(rasa1a)

CSAI:

133450401

XMA:	102236247(rasa1)

XCO:	114154589(rasa1)

XHE:	116729785(rasa1)

PRET:

103470445(rasa1)

PFOR:

103145096(rasa1)

PLAI:

106940421(rasa1)

PMEI:

106932979(rasa1)

GAF:	122828190(rasa1a)

PPRL:

129372006

CVG:	107084547(rasa1)

CTUL:

119773016(rasa1a)

GMU:	124877788(rasa1a)

NFU:	107393876(rasa1)

KMR:	108242834(rasa1a)

ALIM:

106537030(rasa1)

NWH:	119413987(rasa1a)

AOCE:

111562502(rasa1a)

EJA:

138215763

BFRE:

138621663(rasa1a)

MCEP:

125011987(rasa1a)

CSEM:

103397270(rasa1)

POV:	109633794(rasa1)

SSEN:

122770075(rasa1a)

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

118313905(rasa1a)

LCF:

108878516

SDU:	111226968(rasa1)

SLAL:

111651557(rasa1)

XGL:	120805099(rasa1a)

HCQ:	109520643(rasa1)

SSCV:

125993874(rasa1a)

SBIA:

133499135

PEE:

133400067

PTAO:

133474970

BPEC:

110157960(rasa1)

ENY:

140347503

MALB:

109956915(rasa1)

BSPL:

114862064(rasa1a)

SJO:

128365355

SSCO:

133978882

GMH:	115545162(rasa1)

SASA:

106580138 106585767

STRU:

115164902 115199764

OTW:	112247269 112263373

OMY:	110525313 110535722

OGO:	124034590 124036009(rasa1a)

ONE:	115111300 115139734

OKI:	109875927 109895629

OKE:	118358029 118373138

OMM:	135521447 135539016

OCLA:

139390157 139410659

SALP:

111958018 111973711

SNH:	120047874 120063054(rasa1a)

CCLU:

121550226 121585232

ELS:	105014649(rasa1)

OEP:	134014908(rasa1a)

SFM:	108930023 108938639(rasa1)

PKI:	111855610 111860072

AANG:

118206291(rasa1a) 118212899(rasa1b)

AROT:

135233191 135238872(rasa1b)

CCOG:

133140206(rasa1a) 133142132

LOC:	102688757(rasa1)

PSPA:

121306184 121312929

ARUT:

117403679 117403974

PSEX:

120532863

LCM:	102354006(RASA1)

CMK:	103182667(rasa1b)

RTP:

109916106

CPLA:

122559261(rasa1a)

HOC:	132823051(rasa1a)

LERI:

129695918(rasa1a)

PMRN:

116950821(RASA1)

LRJ:	133354295(RASA1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

PFLL:

DME:	Dmel_CG9209(vap)

DER:

6550515

DSE:

6620727

DSI:	Dsimw501_GD24496(Dsim_GD24496)

DYA:	Dyak_GE15997

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16079

DAZ:

108619327

DNV:

108656827

DHE:

111605549

DVI:	6634829(vap)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135957503(vap)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ002855

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139111751(Vap)

TLN:	139817996(Vap)

HST:

DQU:

CFO:

FEX:

PMEC:

138935342(Vap)

LHU:	105672244(vap)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124221328(vap)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138137343(vap)

DPA:

109538426

ESIM:

136413236(vap)

EFOR:

136343621(vap)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

DCOR:

135800597(vap)

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_204820

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137923336(vap)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106692885(vap)

NLU:

111057429

HVI:

124366136

MQU:

129004154

PHU:	Phum_PHUM244140

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

139692876(vap)

FCD:

DMK:

DPZ:

AFRA:

PVM:	113822181(vap)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123754499(vap)

PTRU:

123501437

ESN:

127006310

MNZ:

135208829

MRJ:	136846122(vap)

PORN:

139751213(vap)

HAZT:

108674013

EAF:

111705268

LSM:	121121819(vap)

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136977320(vap)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

BMY:	BM_BM9765(Bma-gap-3)

LOA:	LOAG_17853

HRO:	HELRODRAFT_173701

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:	111130544 111130774

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

AQU:

SRE:	PTSG_00450

ACAN:

ACA1_100450 ACA1_289220

PIF:	PITG_03334

PSOJ:

PHYSODRAFT_468298

SPAR:

SPRG_20260

» show all

Reference

PMID:3201259

Authors

Trahey M, Wong G, Halenbeck R, Rubinfeld B, Martin GA, Ladner M, Long CM, Crosier WJ, Watt K, Koths K, et al.

Title

Molecular cloning of two types of GAP complementary DNA from human placenta.

Journal

Science 242:1697-700 (1988)
DOI:10.1126/science.3201259

Sequence

[hsa:5921]

Reference

PMID:19022332

Authors

Pamonsinlapatham P, Hadj-Slimane R, Lepelletier Y, Allain B, Toccafondi M, Garbay C, Raynaud F

Title

p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling.

Journal

Biochimie 91:320-8 (2009)
DOI:10.1016/j.biochi.2008.10.010

LinkDB

DBGET integrated database retrieval system