Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes.
The activity of GAT107, an allosteric activator and positive modulator of alpha7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface.