KEGG ORTHOLOGY: K09101

ORTHOLOGY: K09101

Entry

K09101                      KO

Symbol

NCOA1, SRC1, KAT13A

Name

nuclear receptor coactivator 1 [EC:2.3.1.48]

Pathway

map04915

Estrogen signaling pathway

map04919

Thyroid hormone signaling pathway

map05200

Pathways in cancer

map05224

Breast cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1
   04919 Thyroid hormone signaling pathway
    K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1
  09162 Cancer: specific types
   05224 Breast cancer
    K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.48  histone acetyltransferase
     K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HATs (histone acetyltransferases)
    K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1

Other DBs

GO:

0004402

Genes

HSA:	8648(NCOA1)

PTR:	459068(NCOA1)

PPS:	100995476(NCOA1)

GGO:	101143172(NCOA1)

PON:	100432710(NCOA1)

PPYG:

129025443(NCOA1)

NLE:	100586410(NCOA1)

HMH:	116480404(NCOA1)

SSYN:

129468384(NCOA1)

MCC:	718524(NCOA1)

MCF:	101925525(NCOA1)

MTHB:

126933643

MNI:	105479814(NCOA1)

CSAB:

103220667(NCOA1)

CATY:

105578530(NCOA1)

PANU:

101007720(NCOA1)

TGE:	112604793(NCOA1)

MLEU:

105534028(NCOA1)

RRO:	104658456(NCOA1)

RBB:	108543020(NCOA1)

TFN:	117062663(NCOA1)

PTEH:

111554502(NCOA1)

CANG:

105518120(NCOA1)

CJC:	100385756(NCOA1)

SBQ:	101039086(NCOA1)

CIMI:

108303105(NCOA1)

ANAN:

105717899(NCOA1)

CSYR:

103262640(NCOA1)

MMUR:

105884347(NCOA1)

LCAT:

123636668(NCOA1)

ERUF:

138399416(NCOA1)

PCOQ:

105816865(NCOA1)

OGA:	100955534(NCOA1)

MMU:	17977(Ncoa1)

MCAL:

110306510(Ncoa1)

MPAH:

110323985(Ncoa1)

RNO:	313929(Ncoa1)

MCOC:

116079752(Ncoa1)

ANU:	117717173(Ncoa1)

ASYL:

127687494(Ncoa1)

MUN:	110555190(Ncoa1)

CGE:	100755152(Ncoa1)

MAUA:

101843151(Ncoa1)

PROB:

127220044(Ncoa1)

PLEU:

114697171(Ncoa1)

PMAV:

102903720(Ncoa1)

MORG:

121439592 121439593

MFOT:

126490712

AAMP:

119806637(Ncoa1)

CNL:	130866985(Ncoa1)

NGI:	103746491(Ncoa1)

HGL:	101726578(Ncoa1)

CPOC:

100722913(Ncoa1)

CCAN:

109685685

DORD:

105983687(Ncoa1)

DSP:	122122499(Ncoa1)

DMER:

138829091(Ncoa1)

PLOP:

125356680(Ncoa1)

NCAR:

124962973

SVUL:

306643473(NCOA1)

MMMA:

107137457(Ncoa1)

ITI:	101961512(Ncoa1)

SCIL:

308632745(NCOA1)

MAVE:

308273703(NCOA1)

OCU:

100341249

OPI:	101521463(NCOA1)

OCZ:	121164721(NCOA1)

TUP:	102476171(NCOA1)

GVR:	103588816(NCOA1)

CFA:	475684(NCOA1)

CLUD:

112664698(NCOA1)

VVP:	112908518(NCOA1)

VLG:	121491530(NCOA1)

NPO:	129510902(NCOA1)

AML:	100471908(NCOA1)

UMR:	103671686(NCOA1)

UAH:	113270535(NCOA1)

UAR:	123799954(NCOA1)

ELK:

111154077

LLV:

125108503

MPUF:

101694173(NCOA1)

MNP:	132021182(NCOA1)

MLK:	131807294(NCOA1)

NVS:	122915266(NCOA1)

MMAQ:

308348535(NCOA1)

ORO:	101369582(NCOA1)

EJU:	114205787(NCOA1)

ZCA:	113937321(NCOA1)

MLX:	118007647(NCOA1)

MANO:

123850876(NCOA1)

NSU:	110587565(NCOA1)

LWW:	102739512(NCOA1)

FCA:	101094588(NCOA1)

PYU:	121044198(NCOA1)

PCOO:

112864088(NCOA1)

PBG:	122497390(NCOA1)

PVIV:

125161948(NCOA1)

LRUF:

124503065

LGF:	123581457(NCOA1)

AJU:

106989110

PTG:	102950417(NCOA1)

PPAD:

109267562(NCOA1)

PUC:

125937333

PLEZ:

122216555(NCOA1)

HHV:	120235812(NCOA1)

CCRU:

144239875(NCOA1)

BTA:	525346(NCOA1)

BOM:	102281335(NCOA1)

BIU:	109566334(NCOA1)

BJV:	133257350(NCOA1)

BBUB:

102406567(NCOA1)

BKE:	129623394(NCOA1)

BBIS:

104989119(NCOA1)

CHX:	102169302(NCOA1)

OAS:	101107264(NCOA1)

OCAN:

138436713(NCOA1)

BTAX:

128055421(NCOA1)

CSUM:

138087919(NCOA1)

ODA:	120851594(NCOA1)

CCAD:

122441998(NCOA1)

MREE:

136163879(NCOA1)

OVR:	110122890(NCOA1)

MBEZ:

129539228(NCOA1)

SSC:	574068(NCOA1)

CFR:	102511907(NCOA1)

CBAI:

105063876(NCOA1)

CDK:	105100028(NCOA1)

VPC:	102535120(NCOA1)

BACU:

103020002(NCOA1)

BMUS:

118905903(NCOA1)

LVE:	103074990(NCOA1)

OOR:	101282808(NCOA1)

LALB:

132531157(NCOA1)

GMF:	115854259(NCOA1)

DDP:	132435078(NCOA1)

SCOO:

307195889(NCOA1)

PCRS:

137205402(NCOA1)

DLE:	111175004(NCOA1)

PCAD:

102994447(NCOA1)

PSIU:

116764262(NCOA1)

PPHC:

136133878(NCOA1)

NASI:

112412778(NCOA1)

HAMP:

307064439(NCOA1)

ECB:	100056042(NCOA1)

EPZ:	103547826(NCOA1)

EAI:	106841182(NCOA1)

MYB:	102243087(NCOA1)

MYD:	102756974(NCOA1)

MMYO:

118669224(NCOA1)

MLF:	102443319(NCOA1)

MDT:	132213585(NCOA1)

MYUM:

139019729(NCOA1)

PKL:	118717240(NCOA1)

EFUS:

103305555(NCOA1)

POTS:

308255679(NCOA1)

MNA:	107534051(NCOA1)

DRO:	112297749(NCOA1)

SHON:

119001390(NCOA1)

AJM:	119050416(NCOA1)

PDIC:

114498497(NCOA1)

PHAS:

123822444(NCOA1)

MMF:	118630624(NCOA1)

PPAM:

129067282(NCOA1)

HAI:	109385708(NCOA1)

RFQ:	117032776(NCOA1)

RHII:

308505867(NCOA1)

PALE:

102885576(NCOA1)

PGIG:

120621892(NCOA1)

PVP:	105289767(NCOA1)

RAY:	107498504(NCOA1)

MJV:	108397348(NCOA1)

TOD:	119259503(NCOA1)

SARA:

101552369(NCOA1)

SFUM:

130036803(NCOA1)

SETR:

126024055(NCOA1)

LAV:	100673959(NCOA1)

TMU:

101348769

ETF:	101655793(NCOA1)

DNM:	101432707(NCOA1)

MDO:	100025270(NCOA1)

GAS:	123237098(NCOA1)

SHR:	100924872(NCOA1)

AFZ:

127548785

PCW:	110206526(NCOA1)

TVP:	118840782(NCOA1)

PBRV:

138149091(NCOA1)

MLAO:

141504741(NCOA1)

OAA:	100086436(NCOA1)

TACU:

119949242(NCOA1)

GGA:	422016(NCOA1)

PCOC:

116235614(NCOA1)

MGP:	100538778(NCOA1)

CJO:	107312353(NCOA1)

TPAI:

128084637(NCOA1)

LMUT:

125689753(NCOA1)

NMEL:

110395346(NCOA1)

APLA:

101791473(NCOA1)

AACU:

137854952(NCOA1)

OJA:	118164853(NCOA1)

BCLA:

308457143(NCOA1)

ACYG:

106038102(NCOA1)

ABRC:

308192204(NCOA1)

CATA:

118256590(NCOA1)

AFUL:

116488126(NCOA1)

LSR:	110477405(NCOA1)

SCAN:

103824777(NCOA1)

PMOA:

120508534

OTC:

121341204

ATRC:

139586538(NCOA1)

FAB:

101807313

OMA:	130266382(NCOA1)

PHI:	102111489(NCOA1)

ACOE:

138108777(NCOA1)

ETL:

114072359

ZLE:	135445183(NCOA1)

SVG:	106859325(NCOA1)

CCIC:

134042366(NCOA1)

NNT:	104410968(NCOA1)

SHAB:

115610046(NCOA1)

POCC:

134163586(NCOA1)

FPG:	101918284(NCOA1)

FCH:	102057591(NCOA1)

FRS:	119149530(NCOA1)

CCRI:

104158698(NCOA1)

ACUN:

113478859(NCOA1)

ANOC:

141955860(NCOA1)

SURA:

141940423(NCOA1)

TALA:

116962774(NCOA1)

ACHC:

115351413(NCOA1)

HLE:	104841473(NCOA1)

AGEN:

126046635

HHAR:

128151656(NCOA1)

BBUT:

142040730(NCOA1)

GCL:

127014386

LDI:	104347289(NCOA1)

DPUB:

104306756(NCOA1)

PPUS:

135177019(NCOA1)

IIN:	128968814(NCOA1)

BRHI:

104500395(NCOA1)

EGZ:

104127265

NNI:	104014708(NCOA1)

PCRI:

104036233

PARX:

142054226(NCOA1)

PADL:

103913284(NCOA1)

AFOR:

103902384(NCOA1)

FGA:	104076856(NCOA1)

CBOR:

142080020(NCOA1)

CBOY:

140650196(NCOA1)

MAME:

142407919(NCOA1)

CLV:	102092063(NCOA1)

CNIC:

135986841(NCOA1)

NMAY:

308039101(NCOA1)

PLET:

104626300(NCOA1)

CUCA:

104061786(NCOA1)

PCUR:

138717222(NCOA1)

TEO:	104384477(NCOA1)

GAME:

129204690(NCOA1)

OHA:	104328197(NCOA1)

CEUR:

306726987(NCOA1)

CPEA:

104392744(NCOA1)

CVF:	104295683(NCOA1)

RTD:	128906520(NCOA1)

CRID:

134513678(NCOA1)

LMIC:

141741468(NCOA1)

NARQ:

141468153(NCOA1)

AAM:	106488019(NCOA1)

AROW:

112966646(NCOA1)

NPD:	112948737(NCOA1)

DNE:	112984261(NCOA1)

SCAM:

104152754(NCOA1)

ASN:	102375151(NCOA1)

AMJ:	102570822(NCOA1)

CPOO:

109311538(NCOA1)

GGN:	109300225(NCOA1)

PSS:	102458351(NCOA1)

CIZ:	142011634(NCOA1)

CMY:	102943217(NCOA1)

CCAY:

125634735(NCOA1)

LKP:	140908460(NCOA1)

NDS:	141984366(NCOA1)

DCC:	119852476(NCOA1)

CPIC:

101941430(NCOA1)

TST:	117875431(NCOA1)

EOB:	135875670(NCOA1)

CABI:

116830872(NCOA1)

MRV:	120400996(NCOA1)

EMQ:	137142079(NCOA1)

ACS:	100556605(ncoa1)

ASAO:

132761633(NCOA1)

PVT:	110089950(NCOA1)

SUND:

121928648(NCOA1)

PBI:	103054110(NCOA1)

PMUR:

107284860(NCOA1)

CTIG:

120309103(NCOA1)

TSR:

106553109

PGUT:

117667698(NCOA1)

PCAE:

139308585(NCOA1)

APRI:

131189018(NCOA1)

PTEX:

113446359(NCOA1)

NSS:	113414574(NCOA1)

VKO:	123033632(NCOA1)

PMUA:

114594932(NCOA1)

PRAF:

128411456(NCOA1)

ZVI:	118082953(NCOA1)

HCG:	128324534(NCOA1)

GJA:	107105849(NCOA1)

STOW:

125444472(NCOA1)

EMC:	129335685(NCOA1)

XLA:	108717249(ncoa1.L) 108718303(ncoa1.S)

XTR:	100127189(ncoa1)

NPR:	108795541(NCOA1)

RTEM:

120936031(NCOA1)

ACAT:

141139064(NCOA1)

PADS:

140327964(NCOA1)

BBUF:

120997165(NCOA1)

BGAR:

122934006(NCOA1)

DTC:	141074290(NCOA1)

PWL:	138295449(NCOA1)

MUO:	115467035(NCOA1)

GSH:	117358214(NCOA1)

DRE:	563288(ncoa1)

DAES:

130247348(ncoa1)

SRX:	107710951 107727606

SANH:

107675037 107689458(ncoa1)

SGH:	107553471(ncoa1) 107558925

CCAR:

109055566 109080239

CAUA:

113062870 113120716

CGIB:

127938438 127984187

PTET:

122324775(ncoa1)

LROH:

127182716(ncoa1)

GRF:	141348484(ncoa1)

OMC:	131526579(ncoa1)

PPRM:

120493323(ncoa1)

RKG:	130103036(ncoa1)

SCEP:

307168334(ncoa1)

MAMB:

125278276(ncoa1)

CIDE:

127501750

CERY:

137019104(ncoa1)

MASI:

127415705 127456684

TROS:

130565681(ncoa1)

TDW:	130434906(ncoa1)

MANU:

129429619(ncoa1)

PDAB:

135738198(ncoa1)

IPU:

108257093

IFU:	128621070(ncoa1)

PHYP:

113529205(ncoa1)

SMEO:

124401289(ncoa1)

TFD:	113637384(ncoa1)

TVC:	132854341(ncoa1)

CGAR:

128544545(ncoa1)

NGRA:

132881588(ncoa1)

TRN:

134320568

AMEX:

103042471(ncoa1)

CMAO:

118815247(ncoa1)

EEE:	113583167(ncoa1)

CHAR:

105900086(ncoa1)

SPIL:

134098064(ncoa1)

ASAD:

121711023(ncoa1)

TRU:	101063899 115252909

TFS:	130516276(ncoa1)

TNG:	GSTEN00035443G001

TBEN:

117487631(ncoa1)

PGEO:

117439674(ncoa1)

GACU:

117549754(ncoa1)

EMAC:

134876820(ncoa1)

ELY:	117270289(ncoa1)

EFO:	125896801(ncoa1)

PLEP:

121955939(ncoa1)

SLUC:

116066020(ncoa1)

ECRA:

117961820(ncoa1)

ESP:	116706287(ncoa1)

PFLV:

114573100(ncoa1)

GAT:	120807841(ncoa1)

PPUG:

119194605(ncoa1)

AFB:	129107081(ncoa1)

CLUM:

117727068(ncoa1)

PSWI:

130202256(ncoa1)

CANA:

137785397(ncoa1)

CVE:	137869518(ncoa1)

MSAM:

119908495(ncoa1)

SCHU:

122862987(ncoa1)

EARM:

139301999(ncoa1)

CUD:	121521918(ncoa1)

SPUL:

138613388(ncoa1)

LMIX:

132984706(ncoa1)

HTC:	141802234(ncoa1)

ALAT:

119012719(ncoa1)

ASTR:

137613225(ncoa1)

PKLU:

139217684(ncoa1)

LCO:	104930087(ncoa1)

MZE:	101474484(ncoa1)

ONL:	100700776(ncoa1)

OAU:	116333125(ncoa1)

OLA:	101163052(ncoa1)

OML:	112157779(ncoa1)

CSAI:

133418649(ncoa1)

XMA:	102232836(ncoa1)

XCO:	114159063(fam184a)

XHE:	116733840(ncoa1)

PRET:

103457314(ncoa1)

PFOR:

103152693(ncoa1)

PLAI:

106954080(ncoa1)

PMEI:

106928269(ncoa1)

GAF:	122825224(ncoa1)

PPRL:

129375430

CVG:	107083511(ncoa1)

CTUL:

119774964(ncoa1)

GMU:	124882468(ncoa1)

NFU:	107377739(ncoa1)

KMR:	108244879(ncoa1)

ALIM:

106534579(ncoa1)

NWH:	119418629(ncoa1)

LTU:	140267483(ncoa1)

AOCE:

111565463(ncoa1)

EJA:	138212079(ncoa1)

BFRE:

138633066(ncoa1)

LCF:

108885261

CSEM:

103381159

POV:	109644845(ncoa1)

SSEN:

122784460(ncoa1)

SSOE:

131443135(ncoa1)

HHIP:

117758055(ncoa1)

HSP:	118099568(ncoa1)

PPLT:

128460536(ncoa1)

SMAU:

118290074(ncoa1)

SDU:	111236426(ncoa1)

SLAL:

111672490(ncoa1)

XGL:	120788572(ncoa1)

HCQ:	109523538(ncoa1)

SSCV:

125990403(ncoa1)

SBIA:

133496656(ncoa1)

PEE:	133417003(ncoa1)

PTAO:

133468312(ncoa1)

BPEC:

110154328

ENY:	140358580(ncoa1)

MALB:

109968845(ncoa1)

BSPL:

114849180(ncoa1)

SJO:	128377201(ncoa1)

SSCO:

133997231(ncoa1)

TTY:	137169948(ncoa1)

SASA:

106571447 106607631

STRU:

115174743 115184015

OTW:	112250355(ncoa1) 112262183

OMY:	110522275 110529656(ncoa1)

OGO:	123990798(ncoa1) 123995541

ONE:	115107802 115139363

OKI:	109866207 109900785

OKE:	118380067 118386948

OMM:	135505929 135557638

OCLA:

139407167 139415175

SALP:

111954103 111972547

SNH:	120019300 120024545

SFON:

129817418 129825161(ncoa1)

CCLU:

121548874 121552655(ncoa1)

ELS:	105017790(ncoa1)

OEP:	134025146(ncoa1)

SFM:	108925185(ncoa1)

PKI:	111854025(ncoa1)

AANG:

118229717(ncoa1)

AROT:

135257484(ncoa1)

CCOG:

133129240(ncoa1)

LOC:	102682284(ncoa1)

ARUT:

117402804(ncoa1)

PSEX:

120525844(ncoa1)

LCM:	102354127(NCOA1)

RTP:	109923709(ncoa1)

CPLA:

122552534(ncoa1)

CPUN:

140482676(ncoa1)

HOC:	132819608(ncoa1)

TPAL:

117641998

CRG:

105320588

» show all

Reference

PMID:9427757

Authors

Kalkhoven E, Valentine JE, Heery DM, Parker MG

Title

Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor.

Journal

EMBO J 17:232-43 (1998)
DOI:10.1093/emboj/17.1.232

Sequence

[hsa:8648]

Reference

PMID:10449719

Authors

Liu Z, Wong J, Tsai SY, Tsai MJ, O'Malley BW

Title

Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin.

Journal

Proc Natl Acad Sci U S A 96:9485-90 (1999)
DOI:10.1073/pnas.96.17.9485

Reference

PMID:12954634

Authors

Litterst CM, Kliem S, Marilley D, Pfitzner E

Title

NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain.

Journal

J Biol Chem 278:45340-51 (2003)
DOI:10.1074/jbc.M303644200

LinkDB

DBGET integrated database retrieval system