KEGG ORTHOLOGY: K10629

ORTHOLOGY: K10629

Entry

K10629                      KO

Symbol

RNF128, GRAIL

Name

E3 ubiquitin-protein ligase RNF128 [EC:2.3.2.27]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10629  RNF128, GRAIL; E3 ubiquitin-protein ligase RNF128
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K10629  RNF128, GRAIL; E3 ubiquitin-protein ligase RNF128
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K10629  RNF128, GRAIL; E3 ubiquitin-protein ligase RNF128

Genes

HSA:	79589(RNF128)

PTR:	738691(RNF128)

PPS:	100975786(RNF128)

GGO:	101151100(RNF128)

PON:	100171545(RNF128)

PPYG:

129025354(RNF128)

NLE:	100606635(RNF128)

HMH:	116811930(RNF128)

SSYN:

129476109(RNF128)

MCC:	700890(RNF128)

MCF:	102143262(RNF128)

MTHB:

126946008

MNI:	105490433(RNF128)

CSAB:

103232446(RNF128)

CATY:

105572387(RNF128)

PANU:

101013462(RNF128)

TGE:	112615630(RNF128)

MLEU:

105532314(RNF128)

RRO:	104670348(RNF128)

RBB:	108522541(RNF128)

TFN:	117077944(RNF128)

PTEH:

111536646(RNF128)

CANG:

105523742(RNF128)

CJC:	100404642(RNF128)

SBQ:	101042510(RNF128)

CIMI:

108316533(RNF128)

ANAN:

105716850(RNF128)

CSYR:

103275457(RNF128)

MMUR:

105863717(RNF128)

LCAT:

123628283(RNF128)

PCOQ:

105811402(RNF128)

OGA:	100967032(RNF128)

MMU:	66889(Rnf128)

MCAL:

110286400(Rnf128)

MPAH:

110313848(Rnf128)

RNO:	315911(Rnf128)

MCOC:

116088853(Rnf128)

ANU:	117693973(Rnf128)

ASYL:

127675367(Rnf128)

MUN:	110541484(Rnf128)

CGE:	100761486(Rnf128)

MAUA:

101830707(Rnf128)

PROB:

127217067(Rnf128)

PLEU:

114710833(Rnf128)

MORG:

121436948 121437281

MFOT:

126489645

AAMP:

119805062(Rnf128)

NGI:	103750046(Rnf128)

HGL:	101698807(Rnf128)

CPOC:

100726928(Rnf128)

CCAN:

109688680(Rnf128)

DORD:

105992818(Rnf128)

DSP:	122116387(Rnf128)

PLOP:

125344249(Rnf128)

NCAR:

124972475

MMMA:

107152414(Rnf128)

ITI:	101965529(Rnf128)

OCU:

100346749

OPI:	101524416(RNF128)

TUP:	102468562(RNF128)

GVR:	103594609(RNF128)

CFA:	492051(RNF128)

CLUD:

112649298(RNF128)

VVP:	112932030(RNF128)

VLG:	121483263(RNF128)

NPO:	129518769(RNF128)

AML:	100464087(RNF128)

UMR:	103668922(RNF128)

UAH:	113241221(RNF128)

UAR:	123785635(RNF128) 123786396

ELK:

111161299

LLV:

125092259

MPUF:

101694275 106007463

MNP:	132007346(RNF128)

MLK:	131821636(RNF128)

NVS:	122897279(RNF128)

ORO:	101363973(RNF128)

EJU:	114198351(RNF128)

ZCA:	113930301(RNF128)

MLX:	118009401 118011815(RNF128)

NSU:	110570169(RNF128) 110573384

LWW:	102747311(RNF128)

FCA:	101080265(RNF128)

PYU:	121025702(RNF128)

PCOO:

112870686(RNF128)

PBG:	122476920(RNF128)

PVIV:

125157841(RNF128)

LRUF:

124514037

LGF:	123594533(RNF128)

AJU:

106985475

PTG:	102965842(RNF128)

PPAD:

109258682(RNF128)

PUC:

125932229

HHV:	120232679(RNF128)

BTA:	535869(RNF128)

BOM:	102287998(RNF128)

BIU:	109554824(RNF128)

BBUB:

102393468(RNF128)

BBIS:

104982928(RNF128)

CHX:	102171851(RNF128)

OAS:	101117223(RNF128)

BTAX:

128070159(RNF128)

CSUM:

138070767(RNF128)

ODA:	120881358(RNF128)

CCAD:

122435144(RNF128)

MREE:

136154213(RNF128)

OVR:	110127614(RNF128)

MBEZ:

129536280 129564189(RNF128)

SSC:	100515872(RNF128)

CFR:	102515408(RNF128)

CBAI:

105061985(RNF128)

CDK:	105095575(RNF128)

VPC:	102539286(RNF128)

BACU:

103018397(RNF128)

BMUS:

118889132(RNF128)

LVE:	103088247(RNF128)

OOR:	101284530(RNF128)

LALB:

132513778(RNF128)

DLE:	111170845(RNF128)

PCAD:

102991457(RNF128)

PSIU:

116748095(RNF128)

NASI:

112402577(RNF128)

ECB:	100054821(RNF128)

EAI:	106839731(RNF128)

MYB:	102242658(RNF128)

MYD:	102772580(RNF128)

MMYO:

118653803(RNF128)

MLF:	102428113(RNF128)

MDT:	132224842(RNF128)

PKL:	118731861(RNF128)

EFUS:

103299481(RNF128)

MNA:	107532134(RNF128)

DRO:	112296884(RNF128)

SHON:

119002028(RNF128)

AJM:	119061604(RNF128)

PDIC:

114505335(RNF128)

PHAS:

123805110(RNF128)

MMF:	118636205(RNF128)

PPAM:

129073234(RNF128)

HAI:	109392823(RNF128)

RFQ:	117029389(RNF128)

PALE:

102894096 102897771

PVP:	105306071(RNF128)

RAY:	107512667(RNF128)

MJV:	108394439(RNF128)

TOD:	119245559(RNF128)

SARA:

101542306(RNF128)

SFUM:

130034089(RNF128)

SETR:

125998632(RNF128)

LAV:	100674068(RNF128)

TMU:

101345379

ETF:	101648385(RNF128)

DNM:	101410991(RNF128)

MDO:	100028589(RNF128)

GAS:	123253728(RNF128)

SHR:	100919367(RNF128)

AFZ:

127542901

PCW:	110194751(RNF128)

TVP:	118833023(RNF128)

PBRV:

138171010(RNF128)

OAA:	100082340(RNF128)

TACU:

119929935(RNF128)

GGA:	422382(RNF128)

PCOC:

116234867(RNF128)

MGP:

100546865

CJO:	107312921(RNF128)

TPAI:

128075931(RNF128)

LMUT:

125699743(RNF128)

NMEL:

110403370(RNF128)

APLA:

101801390(RNF128)

ACYG:

106037752(RNF128)

CATA:

118245252(RNF128)

AFUL:

116494363(RNF128)

TGU:	100226602(RNF128)

LSR:	110480079(RNF128)

SCAN:

103816518

PMOA:

120506261(RNF128)

OTC:	121331814(RNF128)

PRUF:

121363124(RNF128)

ATRC:

139597307(RNF128)

GFR:	102041730(RNF128)

FAB:	101807548(RNF128)

OMA:	130253081(RNF128)

PHI:	102104605(RNF128)

PMAJ:

107203793(RNF128)

CCAE:

111929333

CCW:	104691685(RNF128)

CBRC:

103617874

ACOE:

138110476(RNF128)

ETL:	114059684(RNF128)

ZAB:	102064355(RNF128)

ZLE:	135447976(RNF128)

ACHL:

103807334(RNF128)

SVG:	106856299(RNF128)

MMEA:

130578939(RNF128)

HRT:	120762176(RNF128)

SATI:

136370563(RNF128)

CCIC:

134049991(RNF128)

FPG:	101910947(RNF128)

FCH:	102051744(RNF128)

CCRI:

104168476

SHAB:

115612435(RNF128)

ACUN:

113480225(RNF128)

TALA:

104362992(RNF128)

ACHC:

115333759(RNF128)

HALD:

104317083(RNF128)

HLE:	104832653(RNF128)

AGEN:

126050248

HHAR:

128153785(RNF128)

GCL:

127019601

CSTI:

104564135(RNF128)

LDI:	104349743(RNF128)

MNB:	103777012(RNF128)

PPUS:

135184063(RNF128)

AVIT:

104268137(RNF128)

BRHI:

104490195(RNF128)

EGZ:	104124085(RNF128)

NNI:	104019080(RNF128)

PCRI:

104036328(RNF128)

PCAO:

104048128(RNF128)

PADL:

103922805(RNF128)

AFOR:

103895660(RNF128)

FGA:

104072724

GSTE:

104261674(RNF128)

CLV:	102088421(RNF128)

MUI:	104542533(RNF128)

PGUU:

104458749(RNF128)

PLET:

104615205(RNF128)

EHS:	104503674(RNF128)

CMAC:

104482158

CUCA:

104064025(RNF128)

TEO:	104370546(RNF128)

BREG:

104643239(RNF128)

OHA:	104329579(RNF128)

ACAR:

104526591(RNF128)

CPEA:

104388263(RNF128)

CVF:	104290195(RNF128)

RTD:	128915127(RNF128)

CRID:

134520733(RNF128)

AAM:	106487570(RNF128)

AROW:

112963727(RNF128)

NPD:	112947050(RNF128)

TGT:	104564761(RNF128)

DNE:	112997223(RNF128)

SCAM:

104142192(RNF128)

ASN:	102382448(RNF128)

AMJ:	102572358(RNF128)

CPOO:

109313611(RNF128)

GGN:	109300798(RNF128)

PSS:	102454988(RNF128)

CMY:	102934403(RNF128)

CCAY:

125642883(RNF128)

DCC:	119861749(RNF128)

CPIC:

101951436(RNF128)

TST:	117883023(RNF128)

CABI:

116818511(RNF128)

MRV:	120372637(RNF128)

ACS:

100566066

ASAO:

132763123(RNF128)

PVT:	110090307(RNF128)

SUND:

121936178(RNF128)

PBI:	103061742(RNF128)

PMUR:

107296459(RNF128)

CTIG:

120313128

TSR:	106544421(RNF128)

PGUT:

117676341(RNF128)

APRI:

131205030(RNF128)

PTEX:

113437757(RNF128)

NSS:	113416752(RNF128)

VKO:	123022113(RNF128)

PMUA:

114589275(RNF128)

PRAF:

128406880(RNF128)

ZVI:	118084045(RNF128)

HCG:	128335727(RNF128)

GJA:	107108003(RNF128)

STOW:

125443059(RNF128)

EMC:	129341188(RNF128)

XLA:	108700129(rnf128.S) 779098(rnf128.L)

XTR:	100145171(rnf128)

NPR:	108788662(RNF128)

RTEM:

120913678(RNF128)

BBUF:

120977112(RNF128)

BGAR:

122919569(RNF128)

PWL:	138262632(RNF128)

MUO:	115473864(RNF128)

GSH:	117361061(RNF128)

DRE:	322325(rnf128a)

SRX:	107732618 107746182 107747815 107753233

SANH:

107674870 107680400 107687662

SGH:	107571820 107575186 107592278 107597305

CCAR:

109084591 109090444

CAUA:

113048794 113091379 113113529

CGIB:

127957522 128011630

PTET:

122346178(rnf128a)

LROH:

127166079(rnf128a)

OMC:	131541559(rnf128a)

PPRM:

120470004(rnf128a)

RKG:	130071214(rnf128a)

MAMB:

125266604(rnf128a)

CIDE:

127512946

CERY:

137034799(rnf128a)

MASI:

127418156 127427251 127432970

TROS:

130549427(rnf128a)

TDW:	130420136(rnf128a)

MANU:

129439977(rnf128a)

PDAB:

135732448(rnf128a)

IPU:	108259815(rnf128a) 108268445

IFU:	128603789(rnf128a) 128611868

PHYP:

113542754 113542863

SMEO:

124379103(rnf128a) 124385709

TFD:	113636128 113643870(rnf128a)

TVC:	132840802(rnf128a) 132855484

CGAR:

128517085(rnf128a) 128532009

NGRA:

132875739(rnf128a) 132890601

TRN:	134303577(rnf128a) 134319658

AMEX:

103037493 103044386(rnf128a)

CMAO:

118807243 118814453(rnf128a)

EEE:	113568025 113592260(rnf128)

CHAR:

105906224 122132253(rnf128a)

SPIL:

134069154 134080424(rnf128a)

TRU:

101063222

TFS:	130521896(rnf128a)

TNG:	GSTEN00018070G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

134863118(rnf128a)

ELY:

117251696

EFO:

125904159

PLEP:

121947165

SLUC:

116054652(rnf128a)

ECRA:

117946987(rnf128a)

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

117749573(rnf128a)

PSWI:

130192641

CANA:

137783502

CVE:	137887671(rnf128a)

MSAM:

SCHU:

CUD:

SPUL:

LMIX:

ALAT:

ASTR:

MZE:

ONL:	100710893 109201243 109201447

OAU:	116311649 120438185

OLA:

101174167

OML:

112160530

CSAI:

133459810(rnf128a)

XMA:

102221815

XCO:

114143405

XHE:

116718906

PRET:

103462071(rnf128)

PFOR:

103146144(rnf128)

PLAI:

106935823(rnf128)

PMEI:

106923431(rnf128)

GAF:	122841361(rnf128a)

PPRL:

129369410(rnf128a)

CVG:

107085366

CTUL:

119782421

GMU:	124867294 124867295

NFU:

KMR:

ALIM:

NWH:

AOCE:

111565753(rnf128a)

EJA:	138212857(rnf128a)

BFRE:

138625054

MCEP:

125005640(rnf128a)

CSEM:

103378832

POV:	109637179(rnf128)

SSEN:

122771892

SSOE:

131459921

HHIP:

117759613(rnf128a)

HSP:	118114434(rnf128a)

PPLT:

128446328(rnf128a)

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140381057(rnf128a)

MALB:

109963344

BSPL:

114842856(rnf128a)

SJO:

128358544

SSCO:

133985127

GMH:

115558794

SASA:

100195143(rn128) 106603300

STRU:

115149094(rnf128) 115154555

OTW:	112247768 112250262 112257660

OMY:	110506807 110516752 110533855 110537269(rnf128a)

OGO:	123999350 124008743 124033075

ONE:	115105754 115135734

OKI:	109872477 109892580

OKE:	118373916 118381631 118391340(rnf128a)

OMM:	135531930 135548403(rnf128a) 135550508

OCLA:

139384946 139384947 139395925 139418435 139422938

SALP:

111951097 111980802

SNH:	120040019 120040020 120045082 120057183

CCLU:

121573737(rnf128a) 121579924 121584809

ELS:	105025032(rnf128)

OEP:	134028167 134028169 134040095(rnf128a)

SFM:	108931038(rnf128)

PKI:	111835530(rnf128)

AANG:

118224399 118236220(rnf128a)

AROT:

135250322 135262946(rnf128a)

CCOG:

133124392 133133137(rnf128a)

LOC:	102684210(rnf128)

PSPA:

121295821 121318959

ARUT:

117430854 117962403

PSEX:

120537381

LCM:	102354403(RNF128)

CMK:

CPLA:

HOC:

LERI:

Reference

PMID:19060180

Authors

Nakamichi S, Senga Y, Inoue H, Emi A, Matsuki Y, Watanabe E, Hiramatsu R, Ogawa W, Kasuga M

Title

Role of the E3 ubiquitin ligase gene related to anergy in lymphocytes in glucose and lipid metabolism in the liver.

Journal

J Mol Endocrinol 42:161-9 (2009)
DOI:10.1677/JME-08-0145

Sequence

[mmu:66889]

Reference

PMID:19805371

Authors

Kriegel MA, Rathinam C, Flavell RA

Title

E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance.

Journal

Proc Natl Acad Sci U S A 106:16770-5 (2009)
DOI:10.1073/pnas.0908957106

Sequence

[mmu:66889]

Reference

PMID:12705856

Authors

Anandasabapathy N, Ford GS, Bloom D, Holness C, Paragas V, Seroogy C, Skrenta H, Hollenhorst M, Fathman CG, Soares L

Title

GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells.

Journal

Immunity 18:535-47 (2003)
DOI:10.1016/S1074-7613(03)00084-0

Sequence

[hsa:79589] [mmu:66889]

LinkDB

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