KEGG ORTHOLOGY: K16896

ORTHOLOGY: K16896

Entry

K16896                      KO

Symbol

TPCN1

Name

two pore calcium channel protein 1

Pathway

map04020

Calcium signaling pathway

map04142

Lysosome biogenesis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K16896  TPCN1; two pore calcium channel protein 1
09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome biogenesis
    K16896  TPCN1; two pore calcium channel protein 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K16896  TPCN1; two pore calcium channel protein 1
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, two-pore (TPC)
   K16896  TPCN1; two pore calcium channel protein 1

Other DBs

GO:	0005245 0072345

TC:	1.A.1.11.22 1.A.1.11.25

Genes

HSA:	53373(TPCN1)

PTR:	452272(TPCN1)

PPS:	100990039(TPCN1)

GGO:	101131775(TPCN1)

PON:	100447853(TPCN1)

PPYG:

129010058(TPCN1)

NLE:	100604035(TPCN1)

HMH:	116477879(TPCN1)

SSYN:

129460463(TPCN1)

MCC:	712964(TPCN1)

MCF:	102137854(TPCN1)

MTHB:

126931441

MNI:	105493375(TPCN1)

CSAB:

103239164(TPCN1)

CATY:

105573152(TPCN1)

PANU:

101013373(TPCN1)

TGE:	112634637(TPCN1)

MLEU:

105552290(TPCN1)

RRO:	104666652(TPCN1)

RBB:	108512191(TPCN1)

TFN:	117089363(TPCN1)

PTEH:

111537306(TPCN1)

CANG:

105502278(TPCN1)

CJC:	100414671(TPCN1)

SBQ:	101040801(TPCN1)

CIMI:

108314338(TPCN1)

ANAN:

105728830(TPCN1)

CSYR:

103270460(TPCN1)

MMUR:

105864380(TPCN1)

LCAT:

123626018(TPCN1)

ERUF:

138401544(TPCN1)

PCOQ:

105825674(TPCN1)

OGA:	100953245(TPCN1)

MMU:	252972(Tpcn1)

MCAL:

110294094(Tpcn1)

MPAH:

110312841(Tpcn1)

RNO:	246215(Tpcn1)

MCOC:

116068318(Tpcn1)

ANU:	143437684(Tpcn1)

ASYL:

127672379(Tpcn1)

MUN:	110546382(Tpcn1)

CGE:	100770089(Tpcn1)

MAUA:

101841015(Tpcn1)

PROB:

127216020(Tpcn1)

PLEU:

114699633(Tpcn1)

PMAV:

102902843(Tpcn1)

MORG:

121445918(Tpcn1)

MFOT:

126511629

AAMP:

119825517(Tpcn1)

CNL:	130871215(Tpcn1)

NGI:	103745543(Tpcn1)

HGL:	101723791(Tpcn1)

CPOC:

100717872(Tpcn1)

CCAN:

109681964(Tpcn1)

DORD:

105984277(Tpcn1)

DSP:	122098476(Tpcn1)

DMER:

138806559 138826357(Tpcn1)

PLOP:

125349091(Tpcn1)

NCAR:

124990403

MMMA:

107158658(Tpcn1)

ITI:	101962225(Tpcn1)

OCU:

100341301

OPI:	101529232(TPCN1)

OCZ:	121160849(TPCN1)

TUP:	102495039(TPCN1)

GVR:	103590363(TPCN1)

CFA:	477492(TPCN1)

CLUD:

112676593(TPCN1)

VVP:	112935252(TPCN1)

VLG:	121475291(TPCN1)

NPO:	129507735(TPCN1)

AML:	100463932(TPCN1)

UMR:	103661293(TPCN1)

UAH:	113266993(TPCN1)

UAR:	123778702(TPCN1)

ELK:

111156380

LLV:

125081713

MPUF:

101682776(TPCN1)

MNP:	132023186(TPCN1)

MLK:	131811195(TPCN1)

NVS:	122903400(TPCN1)

ORO:	101370929(TPCN1)

EJU:	114219214(TPCN1)

ZCA:	113913128(TPCN1)

MLX:	118018496(TPCN1)

MANO:

123853048(TPCN1)

NSU:	110588311(TPCN1)

LWW:	102732387(TPCN1)

FCA:	101089398(TPCN1)

PYU:	121010117(TPCN1)

PCOO:

112870489(TPCN1)

PBG:	122470251(TPCN1)

PVIV:

125149690(TPCN1)

LRUF:

124518223

LGF:	123588237(TPCN1)

AJU:

106982076

PTG:	102953676(TPCN1)

PPAD:

109277794(TPCN1)

PUC:

125914161

PLEZ:

122204115(TPCN1)

HHV:	120234415(TPCN1)

CCRU:

144218090(TPCN1)

BTA:	510830(TPCN1)

BOM:	102284539(TPCN1)

BIU:	109571196(TPCN1)

BJV:	133228902(TPCN1)

BBUB:

102408726(TPCN1)

BKE:	129630245(TPCN1)

BBIS:

104980024(TPCN1)

CHX:	102189785(TPCN1)

OAS:	101113364(TPCN1)

OCAN:

138422714(TPCN1)

BTAX:

128062014(TPCN1)

CSUM:

138093510(TPCN1)

ODA:	120871124(TPCN1)

CCAD:

122422859(TPCN1)

MREE:

136145563(TPCN1)

OVR:	110144279(TPCN1)

MBEZ:

129542215(TPCN1)

SSC:	106504056(TPCN1)

CFR:	102507532(TPCN1)

CBAI:

105075689(TPCN1)

CDK:	105104932(TPCN1)

VPC:	102539488(TPCN1)

BACU:

103001621(TPCN1)

BMUS:

118879900(TPCN1)

LVE:	103086226(TPCN1)

OOR:	101289676(TPCN1)

LALB:

132504422(TPCN1)

GMF:	115855327(TPCN1)

DDP:	132435910(TPCN1)

DLE:	111162682(TPCN1)

PCAD:

102994869 114484403

PSIU:

116764918(TPCN1)

PPHC:

136132733(TPCN1)

NASI:

112397297(TPCN1)

ECB:	100051154(TPCN1)

EPZ:	103560412(TPCN1)

EAI:	106842240(TPCN1)

MYB:	102244963(TPCN1)

MYD:	102761700(TPCN1)

MMYO:

118678125(TPCN1)

MLF:	102430592(TPCN1)

MDT:	132221972(TPCN1)

MYUM:

138997960(TPCN1)

PKL:	118720384(TPCN1)

EFUS:

103287071(TPCN1)

MNA:	107529621(TPCN1)

DRO:	112310718(TPCN1)

SHON:

118991121(TPCN1)

AJM:	119040439(TPCN1)

PDIC:

114510056(TPCN1)

PHAS:

123821240(TPCN1)

MMF:	118639904(TPCN1)

PPAM:

129087436(TPCN1)

HAI:	109382261(TPCN1)

RFQ:	117017693(TPCN1)

PALE:

102890223(TPCN1)

PGIG:

120606740(TPCN1)

PVP:	105289240(TPCN1)

RAY:	107517122(TPCN1)

MJV:	108386925(TPCN1)

TOD:	119244955(TPCN1)

SARA:

101554669(TPCN1)

SFUM:

130016520(TPCN1)

SETR:

126030565(TPCN1)

LAV:	100676831(TPCN1)

TMU:

101346144

ETF:	101645230(TPCN1)

DNM:	101434556(TPCN1)

MDO:	100028547(TPCN1)

GAS:	123244983(TPCN1)

SHR:	100926196(TPCN1)

AFZ:

127545497

PCW:	110202087(TPCN1)

TVP:	118852276(TPCN1)

PBRV:

138156326(TPCN1)

MLAO:

141501637(TPCN1)

OAA:	100090887(TPCN1)

TACU:

119942693(TPCN1)

GGA:	417033(CATSPER4)

PCOC:

116228325(TPCN1)

MGP:	100539835(TPCN1)

CJO:	107321349(TPCN1)

TPAI:

128083820(TPCN1)

LMUT:

125701578(TPCN1)

NMEL:

110406532(TPCN1)

APLA:

101795362(TPCN1)

AACU:

137841166(TPCN1)

OJA:	118175111(TPCN1)

ACYG:

106031372(TPCN1)

CATA:

118252953(TPCN1)

AFUL:

116496160(TPCN1)

TGU:	100231420(TPCN1)

LSR:	110481368(TPCN1)

VMC:	128816215(TPCN1)

VCHA:

128797014(TPCN1)

AIB:	137484797(TPCN1)

SCAN:

103818054(TPCN1)

PMOA:

120510318(TPCN1)

OTC:	121344359(TPCN1)

PRUF:

121364834(TPCN1)

ATRC:

139598733(TPCN1)

MATE:

118692975(TPCN1)

MAEN:

136564241(TPCN1)

GFR:	102045019(TPCN1)

FAB:	101809353(TPCN1)

OMA:	130259637(TPCN1)

PHI:	102106808(TPCN1)

PMAJ:

107211707(TPCN1)

CCAE:

111936569(TPCN1)

CCW:	104695006(TPCN1)

CBRC:

103623755(TPCN1)

ACOE:

138119441(TPCN1)

ETL:	114056592(TPCN1)

ZAB:	102074246(TPCN1)

ZLE:	135454448(TPCN1)

ACHL:

103797390(TPCN1)

SVG:	106864880(TPCN1)

MMEA:

130578250(TPCN1)

HRT:	120760442(TPCN1)

SATI:

136368881(TPCN1)

CFAI:

136298743(TPCN1)

CCIC:

134051141(TPCN1)

FPG:	101917907(TPCN1)

FCH:	102058452(TPCN1)

FRS:	119148941(TPCN1)

CCRI:

104162093(TPCN1)

NNT:	104402900(TPCN1)

SHAB:

115614507(TPCN1)

POCC:

134170092(TPCN1)

ACUN:

113486031(TPCN1)

ANOC:

141967204(TPCN1)

SURA:

141951146(TPCN1)

TALA:

104358741(TPCN1)

ACHC:

115345690(TPCN1)

HALD:

104323152(TPCN1)

HLE:	104835989(TPCN1)

AGEN:

126040710

HHAR:

128145507(TPCN1)

BBUT:

142037396(TPCN1)

GCL:

127022887

CSTI:

104554248(TPCN1)

LDI:	104344165(TPCN1)

MNB:	103773939(TPCN1)

DPUB:

104308448(TPCN1)

PPUS:

135189045(TPCN1)

IIN:	128975579(TPCN1)

AVIT:

104276721(TPCN1)

BRHI:

104495180(TPCN1)

EGZ:	104129865(TPCN1)

NNI:	104011470(TPCN1)

PCRI:

104031354(TPCN1)

PCAO:

104052216

PARX:

142064806(TPCN1)

PADL:

103922644(TPCN1)

AFOR:

103905764(TPCN1)

FGA:	104083895(TPCN1)

CBOR:

142090033(TPCN1)

GSTE:

104255859(TPCN1)

CBOY:

140659769(TPCN1)

MAME:

142416736(TPCN1)

CLV:	102085256(TPCN1)

CNIC:

135995272(TPCN1)

MUI:	104536357(TPCN1)

PGUU:

104472478(TPCN1)

PLET:

104626723(TPCN1)

EHS:	104509004(TPCN1)

CMAC:

104486971(TPCN1)

CUCA:

104064324(TPCN1)

PCUR:

138728166(TPCN1)

TEO:	104383611(TPCN1)

BREG:

104637943(TPCN1)

GAME:

129213624(TPCN1)

OHA:	104331429(TPCN1)

ACAR:

104529061(TPCN1)

CPEA:

104397336(TPCN1)

CVF:	104289634(TPCN1)

RTD:	128917074(TPCN1)

CRID:

134522801(TPCN1)

LMIC:

141750695(TPCN1)

NARQ:

141472670(TPCN1)

AAM:	106496292(TPCN1)

AROW:

112970604(TPCN1)

NPD:	112945849(TPCN1)

TGT:	104567818(TPCN1)

DNE:	112994681(TPCN1)

SCAM:

104141647(TPCN1)

ASN:	102374955(TPCN1)

AMJ:	102559623(TPCN1)

CPOO:

109313024(TPCN1)

GGN:	109290280(TPCN1)

PSS:	102452887(TPCN1)

CIZ:	142022744(TPCN1)

CMY:	102939478(TPCN1)

CCAY:

125622733(TPCN1)

LKP:	140898518(TPCN1)

NDS:	141999213(TPCN1)

DCC:	119843639(TPCN1)

CPIC:

101931600(TPCN1)

TST:	117888273(TPCN1)

EOB:	135890345(TPCN1)

CABI:

116817874(TPCN1)

MRV:	120385947(TPCN1)

EMQ:	137154485(TPCN1)

ACS:	100560676(tpcn1)

ASAO:

132781300(TPCN1)

PVT:	110086274(TPCN1)

SUND:

121916442(TPCN1)

PBI:

103058401

PMUR:

107298901(TPCN1)

CTIG:

120303190(TPCN1)

PGUT:

117656514(TPCN1)

PCAE:

139321745(TPCN1)

APRI:

131185655(TPCN1)

PTEX:

113448076(TPCN1)

NSS:	113423298(TPCN1)

VKO:	123032790(TPCN1)

PMUA:

114587032(TPCN1)

PRAF:

128403427(TPCN1)

ZVI:	118075798(TPCN1)

HCG:	128338210(TPCN1)

GJA:	107122250(TPCN1)

STOW:

125442567(TPCN1)

EMC:	129341544(TPCN1)

XLA:	108715505(tpcn1.L)

XTR:	100497529(tpcn1)

NPR:	108791301(TPCN1)

RTEM:

120938949(TPCN1)

ACAT:

141144564(TPCN1)

PADS:

140333574(TPCN1)

BBUF:

120988888(TPCN1)

BGAR:

122924327(TPCN1)

DTC:	141057979(TPCN1)

HSQ:	130280140(TPCN1)

PCOB:

134888481(TPCN1)

PWL:	138266131(TPCN1)

MUO:	115480190(TPCN1)

GSH:	117365418(TPCN1)

DRE:	567534(tpcn1)

DAES:

130229060(tpcn1)

SRX:	107732611 107733226

SANH:

107672457 107680394

SGH:	107592268(tpcn1)

CCAR:

109090313

CAUA:

113048813 113091373

CGIB:

127957543 128011545

PTET:

122345068(tpcn1)

LROH:

127165749(tpcn1)

GRF:	141335337(tpcn1)

OMC:	131540834(tpcn1)

PPRM:

120469706(tpcn1)

RKG:	130091888(tpcn1)

MAMB:

125266586(tpcn1)

CIDE:

127512916

CERY:

137033675(tpcn1)

MASI:

127427165 127431993

TROS:

130571588(tpcn1)

TDW:	130419726(tpcn1)

MANU:

129439959(tpcn1)

PDAB:

135732468(tpcn1)

IPU:

108262656

SMEO:

124379197(tpcn1)

TVC:	132840807(tpcn1)

CGAR:

128512427(tpcn1)

NGRA:

132875895(tpcn1)

TRN:	134303466(tpcn1)

AMEX:

103033570(tpcn1)

CMAO:

118814433(tpcn1)

EEE:

113591062

CHAR:

105890473 122129035

SPIL:

134080739(tpcn1)

ASAD:

121708424(tpcn1)

TRU:	101080229(tpcn1)

TFS:	130525859(tpcn1)

TNG:	GSTEN00029555G001

LCO:	104921233(tpcn1)

NCC:	104947823(tpcn1)

TBEN:

117475997(tpcn1)

CGOB:

115013211(tpcn1)

PGEO:

117452077 117452621

GACU:

117546213(tpcn1)

EMAC:

134873355(tpcn1)

ELY:	117252535(tpcn1)

EFO:	125889975(tpcn1)

PLEP:

121944021(tpcn1)

SLUC:

116056798(tpcn1)

SVIT:

144518166(tpcn1)

ECRA:

117944712(tpcn1)

ESP:	116689292(tpcn1)

PFLV:

114555243(tpcn1)

PFLT:

120560577(tpcn1)

GAT:	120830515(tpcn1)

PPUG:

119224783(tpcn1)

AFB:	129100866(tpcn1)

CLUM:

117736212(tpcn1)

PSWI:

130196053(tpcn1)

CANA:

137805081(tpcn1)

CVE:	137867397(tpcn1)

AMIR:

142957355(tpcn1)

MSAM:

119892195(tpcn1)

SCHU:

122876456(tpcn1)

EARM:

139284035(tpcn1)

CUD:	121509631(tpcn1)

SPUL:

138610257(tpcn1)

LMIX:

132974202(tpcn1)

HTC:	141790255(tpcn1)

ALAT:

119019253(tpcn1)

ASTR:

137592488(tpcn1)

PKLU:

139203459(tpcn1)

MZE:	101473190(tpcn1)

ONL:	100712128(tpcn1)

OAU:	116332439(tpcn1)

OLA:	101159752(tpcn1)

OML:	112148250(tpcn1)

CSAI:

133450453(tpcn1)

XMA:	102236160(tpcn1)

XCO:	114154248(tpcn1)

XHE:	116729701(tpcn1)

PRET:

103470365(tpcn1)

PFOR:

103142914(tpcn1)

PLAI:

106944574(tpcn1)

PMEI:

106930712(tpcn1)

GAF:	122828846(tpcn1)

PPRL:

129371978(tpcn1)

CVG:	107100044(tpcn1)

CTUL:

119786617(tpcn1)

GMU:	124877661(tpcn1)

NFU:	107393941(tpcn1)

KMR:	108234584(tpcn1)

ALIM:

106521726(tpcn1)

NWH:	119413968(tpcn1)

LTU:	140309934(tpcn1)

AOCE:

111584846(tpcn1)

EJA:	138191486(tpcn1)

BFRE:

138627225(tpcn1)

MCEP:

125012086(tpcn1)

CSEM:

103398205(tpcn1)

POV:	109638177(tpcn1)

SSEN:

122769562(tpcn1)

SSOE:

131463764(tpcn1)

HHIP:

117767232(tpcn1)

HSP:	118114890(tpcn1)

PPLT:

128438157(tpcn1)

SMAU:

118313534(tpcn1)

LCF:

108878208

SDU:	111226726(tpcn1)

SLAL:

111660304(tpcn1)

XGL:	120805107(tpcn1)

HCQ:	109514130(tpcn1)

SSCV:

125994263(tpcn1)

SBIA:

133499962(tpcn1)

PEE:	133399801(tpcn1)

PTAO:

133475385(tpcn1)

BPEC:

110156700(tpcn1)

ENY:	140347070(tpcn1)

MALB:

109956877(tpcn1)

BSPL:

114862683(tpcn1)

SJO:	128365125(tpcn1)

SSCO:

133978454(tpcn1)

TTY:	137196266(tpcn1)

GMH:	115553547(tpcn1)

SASA:

106580301(tpcn1) 106585001

STRU:

115164413 115200228(tpcn1)

OTW:	112248549 112262817(tpcn1)

OMY:	110525757 110536131(tpcn1)

OGO:	124034250 124036390(tpcn1)

ONE:	115111673 115140136(tpcn1)

OKI:	109880736 109895982(tpcn1)

OKE:	118358421(tpcn1) 118393288

OMM:	135514005(tpcn1) 135542442

OCLA:

139389464 139410989

SALP:

111958163 111974650

SNH:	120028252 120063300(tpcn1)

SFON:

129826422(tpcn1) 129853660

CCLU:

121573841 121584919

ELS:	105025578(tpcn1)

OEP:	134015186(tpcn1)

SFM:	108927217(tpcn1)

PKI:	111847466(tpcn1)

AANG:

118206696 118212486

AROT:

135233784 135239205

CCOG:

133140958 133141464

LOC:	102687385(tpcn1)

PSPA:

121297165 121299866

ARUT:

117426975(tpcn1)

PSEX:

120541035(tpcn1)

LCM:	102358983(TPCN1)

CMK:	103184365(tpcn1)

RTP:	109912313(tpcn1)

CPLA:

122562720(tpcn1)

CPUN:

140487925(tpcn1)

HOC:	132827362(tpcn1)

SCAU:

119962659(tpcn1)

LERI:

129709335(tpcn1)

HAKA:

140738306(tpcn1)

BFO:

118425979

BBEL:

109465733

SPU:	579495(TPC1)

LPIC:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:	117108872 117108873

SKO:

102801923

AME:	413609(Tpcn1)

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

APUR:

144471688(Tpcn1)

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108726716(Tpcn1)

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

139104032(Tpcn1)

TLN:	139819073(Tpcn1)

TAME:

143901801(Tpcn1)

HST:

DQU:

CFO:

FEX:

PMEC:

138939607(Tpcn1)

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141533790(Tpcn1)

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124214946(Tpcn1)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

SOY:

RFG:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206837

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

ECLR:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

NLU:

LDA:

HVI:

MQU:	128997861 128998017

PHU:	Phum_PHUM215330

FOC:

TPAL:

ZNE:

CSEC:

PAME:

SGRE:

BROR:

IEL:

HAMR:

FCD:

DPX:	DAPPUDRAFT_52339

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

SPRM:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

OOT:

EAF:

LSM:

TCF:

DSV:

DALB:

RSAN:

RMP:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

LGI:	LOTGIDRAFT_122118

PVUL:

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:	107340800 107352507

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:	124435018 124451592

AQU:

105312128

CCLM:

134177482 134178450 134189081

MBR:	MONBRDRAFT_30365

» show all

Reference

PMID:23063126

Authors

Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H

Title

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.

Journal

Cell 151:372-83 (2012)
DOI:10.1016/j.cell.2012.08.036

Sequence

[mmu:252972]

LinkDB

DBGET integrated database retrieval system