KEGG   ORTHOLOGY: K24528
Entry
K24528                      KO                                     
Symbol
mycAI
Name
protomycinolide IV synthase 1
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Reaction
R12660  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24528  mycAI; protomycinolide IV synthase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24528  mycAI; protomycinolide IV synthase 1
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Protomycinolide IV synthase
     K24528  mycAI; protomycinolide IV synthase 1
Genes
SGK: PET44_28360
AG: BAC57028(mycAI)
Reference
PMID:15358416
  Authors
Anzai Y, Ishii Y, Yoda Y, Kinoshita K, Kato F.
  Title
The targeted inactivation of polyketide synthase mycAV in the mycinamicin producer, Micromonospora griseorubida, and a complementation study.
  Journal
FEMS Microbiol Lett 238:315-20 (2004)
DOI:10.1016/j.femsle.2004.07.050
  Sequence
[ag:BAC57028]
LinkDB

KEGG   ORTHOLOGY: K24559
Entry
K24559                      KO                                     
Symbol
mycAII
Name
protomycinolide IV synthase 2
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Reaction
R12660  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24559  mycAII; protomycinolide IV synthase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24559  mycAII; protomycinolide IV synthase 2
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Protomycinolide IV synthase
     K24559  mycAII; protomycinolide IV synthase 2
Genes
SGK: PET44_28365
AG: BAC57029(mycAII)
Reference
PMID:15358416
  Authors
Anzai Y, Ishii Y, Yoda Y, Kinoshita K, Kato F.
  Title
The targeted inactivation of polyketide synthase mycAV in the mycinamicin producer, Micromonospora griseorubida, and a complementation study.
  Journal
FEMS Microbiol Lett 238:315-20 (2004)
DOI:10.1016/j.femsle.2004.07.050
  Sequence
[ag:BAC57029]
LinkDB

KEGG   ORTHOLOGY: K24560
Entry
K24560                      KO                                     
Symbol
mycAIII
Name
protomycinolide IV synthase 3
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Reaction
R12660  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24560  mycAIII; protomycinolide IV synthase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24560  mycAIII; protomycinolide IV synthase 3
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Protomycinolide IV synthase
     K24560  mycAIII; protomycinolide IV synthase 3
Genes
AG: BAC57030(mycAIII)
Reference
PMID:15358416
  Authors
Anzai Y, Ishii Y, Yoda Y, Kinoshita K, Kato F.
  Title
The targeted inactivation of polyketide synthase mycAV in the mycinamicin producer, Micromonospora griseorubida, and a complementation study.
  Journal
FEMS Microbiol Lett 238:315-20 (2004)
DOI:10.1016/j.femsle.2004.07.050
  Sequence
[ag:BAC57030]
LinkDB

KEGG   ORTHOLOGY: K24561
Entry
K24561                      KO                                     
Symbol
mycAIV
Name
protomycinolide IV synthase 4
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Reaction
R12660  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24561  mycAIV; protomycinolide IV synthase 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24561  mycAIV; protomycinolide IV synthase 4
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Protomycinolide IV synthase
     K24561  mycAIV; protomycinolide IV synthase 4
Genes
AG: BAC57031(mycAIV)
Reference
PMID:15358416
  Authors
Anzai Y, Ishii Y, Yoda Y, Kinoshita K, Kato F.
  Title
The targeted inactivation of polyketide synthase mycAV in the mycinamicin producer, Micromonospora griseorubida, and a complementation study.
  Journal
FEMS Microbiol Lett 238:315-20 (2004)
DOI:10.1016/j.femsle.2004.07.050
  Sequence
[ag:BAC57031]
LinkDB

KEGG   ORTHOLOGY: K24562
Entry
K24562                      KO                                     
Symbol
mycAV
Name
protomycinolide IV synthase 5
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Reaction
R12660  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24562  mycAV; protomycinolide IV synthase 5
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24562  mycAV; protomycinolide IV synthase 5
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Protomycinolide IV synthase
     K24562  mycAV; protomycinolide IV synthase 5
Genes
AG: BAC57032(mycAV)
Reference
PMID:15358416
  Authors
Anzai Y, Ishii Y, Yoda Y, Kinoshita K, Kato F.
  Title
The targeted inactivation of polyketide synthase mycAV in the mycinamicin producer, Micromonospora griseorubida, and a complementation study.
  Journal
FEMS Microbiol Lett 238:315-20 (2004)
DOI:10.1016/j.femsle.2004.07.050
  Sequence
[ag:BAC57032]
LinkDB

KEGG   REACTION: R12660
Entry
R12660                      Reaction                               
Definition
3 Malonyl-CoA + 5 Methylmalonyl-CoA + 7 NADPH + 7 H+ <=> Protomycinolide IV + 8 CoA + 8 CO2 + 4 H2O + 7 NADP+
Equation
3 C00083 + 5 C02557 + 7 C00005 + 7 C00080 <=> C15685 + 8 C00010 + 8 C00011 + 4 C00001 + 7 C00006
Comment
protomycinolide IV synthase,MycAI-AV
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
Orthology
K24528  protomycinolide IV synthase 1
K24559  protomycinolide IV synthase 2
K24560  protomycinolide IV synthase 3
K24561  protomycinolide IV synthase 4
K24562  protomycinolide IV synthase 5
Reference
1  [PMID:15358416]
  Authors
Anzai Y, Ishii Y, Yoda Y, Kinoshita K, Kato F.
  Title
The targeted inactivation of polyketide synthase mycAV in the mycinamicin producer, Micromonospora griseorubida, and a complementation study.
  Journal
FEMS Microbiol Lett 238:315-20 (2004)
DOI:10.1016/j.femsle.2004.07.050
Reference
2  [PMID:12583909]
  Authors
Anzai Y, Saito N, Tanaka M, Kinoshita K, Koyama Y, Kato F
  Title
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.
  Journal
FEMS Microbiol Lett 218:135-41 (2003)
DOI:10.1111/j.1574-6968.2003.tb11509.x
LinkDB

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