KEGG ORTHOLOGY: K28128

ORTHOLOGY: K28128

Entry

K28128                      KO

Symbol

HYPK

Name

huntingtin-interacting protein K

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K28128  HYPK; huntingtin-interacting protein K
   03036 Chromosome and associated proteins
    K28128  HYPK; huntingtin-interacting protein K
Chaperones and folding catalysts [BR:ko03110]
Other chaperones and cochaperones
  Others
   K28128  HYPK; huntingtin-interacting protein K
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Sister chromatid cohesion proteins
   Other sister chromatid cohesion factors
    K28128  HYPK; huntingtin-interacting protein K

Genes

HSA:	25764(HYPK)

PTR:	104002286(HYPK)

PPS:	100989225(HYPK)

GGO:	101127706(HYPK)

PON:	100438191(HYPK)

PPYG:

129014651(HYPK)

NLE:	100583616(HYPK)

HMH:	116482174(HYPK)

SSYN:

129481726(HYPK)

MCC:	713266(HYPK)

MCF:	102116290(HYPK)

MTHB:

126959888

MNI:	105491324(HYPK)

CSAB:

103245729(HYPK)

CATY:

105588143(HYPK)

PANU:

100137436(HYPK)

TGE:	112627427(HYPK)

MLEU:

105549422(HYPK)

RRO:	104679625(HYPK)

RBB:	108521295(HYPK)

TFN:	117070766(HYPK)

PTEH:

111524224 111529490 113219833

CANG:

105511089(HYPK)

CJC:	100397052(HYPK)

SBQ:	101052787(HYPK)

CIMI:

108316243(HYPK)

ANAN:

105709974(HYPK)

CSYR:

103262008(HYPK)

MMUR:

105872533(HYPK)

LCAT:

123630583(HYPK)

PCOQ:

105814377(HYPK)

OGA:	100945585(HYPK)

MMU:	67693(Hypk)

MCAL:

110311687(Hypk)

MPAH:

110319214(Hypk)

RNO:	311359(Hypk)

MCOC:

116090799(Hypk)

ANU:	117703062(Hypk)

ASYL:

127685809(Hypk)

MUN:	110556219(Hypk)

CGE:	100753787(Hypk)

MAUA:

101840900(Hypk)

PROB:

127221559(Hypk)

PLEU:

114699592(Hypk)

MORG:

121448700 121457505 121465551(Hypk)

MFOT:

126496763

AAMP:

119814749(Hypk) 119820210

NGI:	103746735(Hypk)

HGL:	101722733(Hypk)

CPOC:

100718702(Hypk)

CCAN:

109681443(Hypk)

DORD:

105981116(Hypk)

DSP:	122114385(Hypk)

PLOP:

125340360(Hypk)

NCAR:

124977015

MMMA:

107138154(Hypk)

ITI:	101961187(Hypk)

OCU:	100328687(HYPK)

OPI:	101529335(HYPK)

TUP:	102474337(HYPK)

GVR:	103605594(HYPK)

CFA:	487528(HYPK)

CLUD:

112676030(HYPK)

VVP:	112920010(HYPK) 112927080

VLG:	121476421 121484731(HYPK)

NPO:	129504172(HYPK)

AML:	100472154(HYPK)

UMR:	103673389(HYPK)

UAH:	113241956(HYPK)

UAR:	123776297(HYPK)

ELK:

111138940

LLV:

125103883

MPUF:

101673842(HYPK)

MNP:	131999697(HYPK)

MLK:	131836209(HYPK)

NVS:	122894459(HYPK)

ORO:	101373331 101374158(HYPK)

EJU:	114226576(HYPK)

ZCA:	113908904(HYPK) 113924780 113930449

MLX:	118003417(HYPK) 118017777 118023190

NSU:	110585184(HYPK) 110593967

LWW:	102731418(HYPK)

FCA:	101096321(HYPK)

PYU:	121041613(HYPK)

PCOO:

112856026(HYPK)

PBG:	122468725(HYPK)

PVIV:

125167506(HYPK)

LRUF:

124508643

LGF:	123583115(HYPK)

AJU:

106968478

PTG:	102948541(HYPK)

PPAD:

109263072(HYPK)

PUC:

125909942

PLEZ:

122222111(HYPK)

HHV:	120232199(HYPK)

BTA:	100138230(HYPK)

BOM:	102283092(HYPK)

BIU:	109575362(HYPK)

BBUB:

102408885(HYPK)

BBIS:

104985797(HYPK)

CHX:	102185509(HYPK)

OAS:	101111231(HYPK)

BTAX:

128066556(HYPK)

CSUM:

138095550(HYPK)

ODA:	120875006(HYPK)

CCAD:

122419604(HYPK)

MREE:

136147146(HYPK)

OVR:	110129816(HYPK)

MBEZ:

129550575(HYPK)

CFR:	102504732(HYPK)

CBAI:

105076967(HYPK)

CDK:	105101711(HYPK)

VPC:	102539317(HYPK)

BACU:

103001463(HYPK)

BMUS:

118889675(HYPK)

LVE:	103077957(HYPK)

OOR:	101281910(HYPK)

LALB:

132520206(HYPK)

DLE:	111181660(HYPK)

PCAD:

102980090(HYPK)

PSIU:

116749200(HYPK)

NASI:

112391214(HYPK)

ECB:	100056156(HYPK)

EPZ:	103540689(HYPK)

EAI:	106835014(HYPK)

MYB:	102257541(HYPK)

MYD:	102757210(HYPK)

MMYO:

118651002(HYPK)

MLF:	102434719(HYPK)

MDT:	132215211 132238186(HYPK)

MYUM:

139016070(HYPK)

PKL:	118722407(HYPK)

EFUS:

103287373(HYPK)

MNA:	107536309(HYPK)

DRO:	112311461(HYPK)

SHON:

118992563(HYPK)

AJM:	119054000(HYPK)

PDIC:

114492288(HYPK)

PHAS:

123808904(HYPK)

MMF:	118631338(HYPK)

PPAM:

129064291(HYPK) 129076228

HAI:	109384025(HYPK)

RFQ:	117023733(HYPK)

PALE:

102882171(HYPK)

PGIG:

120622716(HYPK)

PVP:	105288798(HYPK)

MJV:	108403901(HYPK)

TOD:	119238560(HYPK)

SARA:

101541873(HYPK)

SFUM:

130042087(HYPK)

SETR:

126020913(HYPK)

LAV:	100657101(HYPK)

TMU:

101342422

ETF:	101645420(HYPK)

DNM:	101429099(HYPK)

MDO:

100013325

GAS:	123235940(HYPK)

SHR:	100921204(HYPK)

AFZ:

127549317

PCW:	110223695(HYPK)

TVP:	118829265(HYPK)

PBRV:

138170133 138175474(HYPK)

OAA:	114813813(HYPK)

TACU:

119931736(HYPK)

GGA:	770307(HYPK)

PCOC:

116225535(HYPK)

MGP:	100550917(HYPK)

CJO:	107318973(HYPK)

TPAI:

128075219(HYPK)

LMUT:

125698338(HYPK)

NMEL:

110403729(HYPK)

APLA:

119718023(HYPK)

ACYG:

125179807(HYPK)

CATA:

118259434(HYPK)

AFUL:

116493575(HYPK)

TGU:	115496558(HYPK)

LSR:	110476673(HYPK)

SCAN:

103816286(HYPK)

PMOA:

120509011(HYPK)

OTC:	121343696(HYPK)

PRUF:

121352258(HYPK)

ATRC:

139596647(HYPK)

GFR:	102041974(HYPK)

FAB:	101807974(HYPK)

OMA:	130257173(HYPK)

PHI:	102101705(HYPK)

PMAJ:

107209438(HYPK)

CCAE:

111945203(HYPK)

CCW:	104683849(HYPK)

CBRC:

103619572(HYPK)

ACOE:

138116663(HYPK)

ETL:	114064272(HYPK)

ZLE:	135452355(HYPK)

SVG:	106860147(HYPK)

MMEA:

130575799(HYPK)

HRT:	120758908(HYPK)

SATI:

136366849(HYPK)

CCIC:

134049239(HYPK)

NNT:	104411484(HYPK)

SHAB:

115612927(HYPK)

TALA:

116960457(HYPK)

ACHC:

115341391(HYPK)

HLE:	104834764(HYPK)

AGEN:

126043523

HHAR:

128151042(HYPK)

DPUB:

104297397(HYPK)

PPUS:

135182710(HYPK)

CBOY:

140655957(HYPK)

PLET:

104624214(HYPK)

CUCA:

104056422(HYPK)

RTD:	128914707(HYPK)

CRID:

134520428(HYPK)

AAM:	106494106(HYPK)

AROW:

112976299(HYPK)

NPD:	112948313(HYPK)

TGT:	104577283(HYPK)

DNE:	112994986(HYPK)

SCAM:

104141023(HYPK)

AMJ:	102567394(HYPK)

PSS:	102460965(HYPK)

CMY:	114019436(HYPK)

CCAY:

125643448(HYPK)

DCC:	119862671(HYPK)

CPIC:

101931218(HYPK)

TST:	117884059(HYPK)

CABI:

116833060(HYPK)

MRV:	120372790(HYPK)

ACS:	100567105(hypk)

ASAO:

132762462(HYPK)

PVT:	110077254(HYPK)

SUND:

121933227(HYPK)

PBI:	103052477(HYPK)

PMUR:

107289786(HYPK)

CTIG:

120316454(HYPK)

TSR:	106545535(HYPK)

PGUT:

117676238(HYPK)

APRI:

131184560(HYPK)

PTEX:

113442119(HYPK)

NSS:	113423324(HYPK)

VKO:	123030747(HYPK)

PMUA:

114584365(HYPK)

PRAF:

128401573(HYPK)

ZVI:	118093222(HYPK)

HCG:	128334909(HYPK)

GJA:	107109721(HYPK)

STOW:

125424655(HYPK)

EMC:	129345147(HYPK)

XLA:	108711438(hypk.L) 447079(hypk.S)

XTR:	100145587(hypk)

NPR:	108800786(HYPK)

RTEM:

120931244(HYPK)

BBUF:

120985897(HYPK)

BGAR:

122929594(HYPK)

PWL:	138284155(HYPK)

MUO:	115460664(HYPK) 115460666

GSH:	117348469(HYPK)

DRE:	100151755(hypk)

SRX:	107730238 107757654

SANH:

107695358 107701274

SGH:	107578433 107596440 107600460

CCAR:

109066947 109067045

CAUA:

113051354 113106267

CGIB:

127961653 128017768

PTET:

122349387(hypk)

LROH:

127168375(hypk)

OMC:	131543805(hypk)

PPRM:

120464793(hypk)

RKG:	130091162(hypk)

MAMB:

125265111(hypk)

CIDE:

127516071

CERY:

137030311(hypk)

MASI:

127414633 127445377

TROS:

130555436(hypk)

TDW:	130421367(hypk)

MANU:

129447597(hypk)

PDAB:

135778693(hypk)

IPU:

108259366

IFU:	128602727(hypk)

PHYP:

113540938(hypk)

SMEO:

124379731(hypk)

TFD:	113636813(hypk)

TVC:	132838659(hypk)

CGAR:

128519412(hypk)

NGRA:

132875064(hypk)

TRN:	134304303(hypk)

AMEX:

103022837(hypk)

CMAO:

118817555(hypk)

EEE:	113579715(hypk)

CHAR:

105908094(hypk)

SPIL:

134095490(hypk)

TRU:	101067790(hypk)

TFS:	130519019(hypk)

TNG:	GSTEN00034757G001

LCO:	104935417(hypk)

NCC:	104964762(hypk)

TBEN:

117471556(hypk)

CGOB:

115006375(hypk)

PGEO:

117464106(hypk)

GACU:

117533667(hypk)

EMAC:

134863251(hypk)

ELY:	117264434(hypk)

EFO:	125905595(hypk)

PLEP:

121942027(hypk)

SLUC:

116067252(hypk)

ECRA:

117941933(hypk)

ESP:	116687267(hypk)

PFLV:

114559925(hypk)

GAT:	120810133(hypk)

PPUG:

119197114(hypk)

AFB:	129103732(hypk)

CLUM:

117728868(hypk)

PSWI:

130193059(hypk)

CANA:

137786509(hypk)

CVE:	137882186(hypk)

MSAM:

119890001(hypk)

SCHU:

122877015(hypk)

CUD:	121510694(hypk)

SPUL:

138593111(hypk)

LMIX:

132987783(hypk)

ALAT:

119017687(hypk)

ASTR:

137593151(hypk)

MZE:	101468262(hypk)

ONL:	100707491(hypk)

OAU:	116324396(hypk)

OLA:	101169905(hypk)

OML:	112140303(hypk)

CSAI:

133458495(hypk)

XMA:	102218891(hypk)

XCO:	114142806(hypk)

XHE:	116718283(hypk)

PRET:

103462962(hypk)

PFOR:

103142682(hypk)

PLAI:

106964632(hypk)

PMEI:

106911682(hypk)

GAF:	122845045(hypk)

PPRL:

129354092(hypk)

CVG:	107091075(hypk)

CTUL:

119798845(hypk)

GMU:	124866780(hypk)

NFU:	107382013(hypk)

KMR:	108247111(hypk)

ALIM:

106526748(hypk)

NWH:	119424681(hypk)

AOCE:

111579672(hypk)

EJA:	138213798(hypk)

BFRE:

138615207

MCEP:

125005599(hypK)

CSEM:

103398465(hypk)

POV:	109642068(hypk)

SSEN:

122772347(hypk)

SSOE:

131459538(hypk)

HHIP:

117753936(hypk)

HSP:	118123855(hypk)

PPLT:

128436722(hypk)

SMAU:

118302584(hypk)

LCF:

108894272

SDU:	111223630(hypk)

SLAL:

111655503(hypk)

XGL:	120789048(hypk)

HCQ:	109514269(hypk)

SSCV:

125967102(hypk)

SBIA:

133498636(hypk)

PEE:	133395426(hypk)

PTAO:

133473266(hypk)

BPEC:

110168844(hypk)

ENY:	140380803(hypk)

MALB:

109954529(hypk)

BSPL:

114852404(hypk)

SJO:	128355145(hypk)

SSCO:

133979067(hypk)

GMH:	115559260(hypk)

SASA:

106562624(hypk)

STRU:

115166919 115203390

OTW:	112238506(hypk)

OMY:	110506855(hypk) 110526669

OGO:	124017833(hypk) 124018909

ONE:	115127494(hypk)

OKI:	109880831 116359640

OKE:	118375538(hypk)

OMM:	135556395(hypk)

OCLA:

139385114 139398489

SALP:

112073248(hypk)

SNH:	120048695(hypk)

CCLU:

121582991(hypk)

ELS:	105014871(hypk)

OEP:	134028134(hypk)

SFM:	108940954(hypk)

PKI:	111845066 111859924

AANG:

118215355 118228364(hypk)

AROT:

135241588 135255466(hypk)

CCOG:

133111837(hypk)

LOC:	102698072(hypk)

PSPA:

121294748(hypk) 121299148

ARUT:

117428112 117429083

PSEX:

120541588(hypk)

LCM:	102358922(HYPK)

CMK:	103188578(hypk)

RTP:	109932642(hypk)

CPLA:

122542578(hypk)

HOC:	132834744(hypk)

LERI:

129713520(hypk)

PMRN:

116941874(HYPK)

LRJ:	133343870(HYPK)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG9922(CG9922)

DER:

6552840

DSE:

6606450

DSI:	Dsimw501_GD20462(Dsim_GD20462)

DYA:	Dyak_GE10068

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DMO:	Dmoj_GI10786

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119682639 119682707

MDE:

SCAC:

LCQ:

LSQ:

CVJ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ008278

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NLO:

NVG:

AROA:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

DCOR:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_201230

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM306680

FOC:

TPAL:

ZNE:

CSEC:

PAME:

SGRE:

BROR:

IEL:

HAMR:

FCD:

DPX:	DAPPUDRAFT_304277

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:	115316987 121836061

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:

ABRU:

LPOL:

CBR:

CRQ:	GCK72_000143

NAI:	NECAME_15092

BMY:	BM_BM10224(Bm10224)

LOA:	LOAG_04147

TSP:

Tsp_02741

HRO:	HELRODRAFT_67931

LGI:	LOTGIDRAFT_118654

PCAN:

112558195

LSAX:

138950671

BGT:

106050895

GAE:	121388159 121392665

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_054560

SHX:	MS3_00004073

OVI:	T265_14165

EGL:

LLON:

NVE:

EPA:

ATEN:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_23390

AQU:

ATH:

ALY:

CRB:

CSAT:

104725359 104744830 104764356

EUS:	EUTSA_v10021793mg

BRP:	103849823 103870732

BNA:	106352945 106401267 106452990 125599753

BOE:	106295431 106328142

RSZ:	108812422 108812442 108863020

THJ:	104805014 104818881

CPAP:

110821219

CIT:

102617621

CIC:	CICLE_v10006264mg

PVY:

116115779

MINC:

123220707

TCC:

18603659

GRA:	105775368 105796909

GHI:	107910570 107936091 107938668 121232359

GAB:	108476247 108481994

HSYR:

120123812 120127673 120159042 120176067

DZI:	111279578 111293415

EGR:

104415236

RARG:

115747723

GMX:	100499958 100527218 100527445 100789285

GSJ:	114366860 114386920 114392932 114419961

PVU:	137807016 137831943

VRA:	106754014 106766932

VAR:	108333390 108341100

VUN:	114176065 114187157

VUM:	124841689 124845884

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:

ADU:

AIP:

AHF:	112741637 112796321

LANG:

109333658

PCIN:

129295191 129310010

QSA:	O6P43_021866

FVE:

AANS:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103403535 103452774

MSYL:

126595871 126608096

PXB:	103928907 103961299

PCOX:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:	110644903 110656314

MESC:

110601566

POP:	7485827 7485901

PEU:	105115337 105122480

PALZ:

118046159 118062455

PNZ:	133696949 133704805

JRE:	108979501 108994780

CILL:

122300358 122317937

CAVE:

132175100 132190603

AGLU:

133879825

QSU:	112000652 136061413

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107808320 107831008

NSY:

104238814

NTO:	104097600 104101898

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

121768249 121771163 121791148

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:	131315919 131321692

AEW:

DLT:

BVG:

SOE:

CQI:	110697285 110738226

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119287589 119312649

TAES:

123087807 123114123 123123610

TUA:

LPER:

LRD:

SBI:

ZMA:

MFLO:

SITA:

SVS:

PVIR:

PHAI:

PAUA:

PDA:	103712662 103721019

MUS:

103969786

ZOF:	122009959 122017663

PEQ:

AOF:

MSIN:

ACAK:

NCOL:

ATR:

CJF:

SMO:	SELMODRAFT_271849 SELMODRAFT_427379

PPP:

112292191

CRE:	CHLRE_01g041000v5

MNG:	MNEG_14281

CSL:	COCSUDRAFT_83514

CVR:	CHLNCDRAFT_137085

MIS:	MICPUN_58343

MPP:	MICPUCDRAFT_56785

RIE:	OCT59_005377

SRE:	PTSG_03566

NGD:	NGA_0204200

PIF:	PITG_08762

PSOJ:

PHYSODRAFT_355308

BLAC:

94349614(CCR75_005869)

SPAR:

SPRG_08253

EHX:	EMIHUDRAFT_64970 EMIHUDRAFT_76408

GTT:	GUITHDRAFT_110293

» show all

Reference

PMID:20154145

Authors

Arnesen T, Starheim KK, Van Damme P, Evjenth R, Dinh H, Betts MJ, Ryningen A, Vandekerckhove J, Gevaert K, Anderson D

Title

The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation.

Journal

Mol Cell Biol 30:1898-909 (2010)
DOI:10.1128/MCB.01199-09

Sequence

[hsa:25764]

Reference

PMID:25446099

Authors

Choudhury KR, Bhattacharyya NP

Title

Chaperone protein HYPK interacts with the first 17 amino acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity.

Journal

Biochem Biophys Res Commun 456:66-73 (2015)
DOI:10.1016/j.bbrc.2014.11.035

LinkDB

DBGET integrated database retrieval system