KEGG   MODULE: M00778
Entry
M00778            Pathway   Module                                 
Name
Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Definition
K05551+K05552+K05553 -K12420 ((K05554,K14249,K15884,K15885) (K05555,K14250),K15886)
Diagram
M00778

Orthology
K05551  
actI1, oxyA, tcmK, snoa1, mtmP; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] [RN:R09258 R09259 R11516 R06643]
K05552  
actI2, oxyB, tcmL, snoa2, mtmK; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] [RN:R09258 R09259 R11516 R06643]
K05553  
actI3, oxyC, tcmM, snoa3, mtmS; minimal PKS acyl carrier protein [RN:R09258 R09259 R11516 R06643]
K12420  
actIII, oxyJ, snoaD; ketoreductase [EC:1.1.1.-] [RN:R09262 R06642 R09263]
K05554  
actVII; aromatase [EC:4.2.1.-] [RN:R09265]
K14249  
oxyK; bifunctional cyclase/aromatase [EC:4.2.1.-] [RN:R09187]
K15884  
snoaE; bifunctional aromatase (cyclase/dehydratase) [EC:4.2.1.-] [RN:R09266]
K15885  
mtmQ; C7-C12 aromatase (ARO/CYC) [EC:4.2.1.-] [RN:R09268]
K05555  
actIV; cyclase [EC:4.-.-.-] [RN:R09305]
K14250  
oxyN, snoaM, mtmY; cyclase [RN:R09188 R09325 R09350]
K15886  
tcmN; multifunctional cyclase / dehydratase / O-methyltransferase [EC:2.3.1.235] [RN:R09269 R09355]
Class
Pathway modules; Biosynthesis of terpenoids and polyketides; Type II polyketide biosynthesis
Pathway
map01056  Biosynthesis of type II polyketide backbone
map00253  Tetracycline biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R09258  
R09259  
R09262  
R09265  
R09305  
R11516  
R06642  
R09187  
R09188  
R06643  
R09260  
R09263  
R09266  
R09325  
R09268  
R09350  
R09269  
Compound
C00083  Malonyl-CoA
C12348  3,5,7,9,11,13,15-Heptaoxo-hexadecanoyl-[acp]
C18327  7,9,12-Octaketide intermediate 1
C18328  7,9,12-Octaketide intermediate 2
C18329  7,9,12-Octaketide intermediate 3
C18353  Octaketide bicyclic intermediate
C21430  Malonamoyl-[acyl-carrier protein]
C12441  18-Carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[acp]
C12442  C-9 Reduced nonaketamide
C18293  Nonaketamide monocyclic intermediate
C18294  Nonaketamide tricyclic intermediate
C12354  3,5,7,9,11,13,15,17,19-Nonaoxo-eicosanoyl-[acp]
C18330  7,9,12-Decaketide intermediate 1
C18331  7,9,12-Decaketide intermediate 2
C18332  7,9,12-Decaketide intermediate 3
C18629  Deoxynogalonate
C18336  7,12-Decaketide intermediate 1
C18709  Decaketide tricyclic intermediate
C18337  9,14-Decaketide intermediate 1
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