KEGG   MODULE: M00833
Entry
M00833            Pathway   Module                                 
Name
Calicheamicin biosynthesis, calicheamicinone => calicheamicin
Definition
K21254 K21255 K21256 K21257 K21258
K21259 K21260 K21261 K21262 K21263
Diagram
M00833

Orthology
K21254  
calO5; orsellinic acid synthase [EC:2.3.1.-] [RN:R11412]
K21255  
calO6; orsellinic acid C2-O-methyltransferase [EC:2.1.1.-] [RN:R11413]
K21256  
calO3; flavin-dependent halogenase [RN:R11414]
K21257  
calO2; orsellenic acid P450 oxidase [EC:1.14.-.-] [RN:R11415]
K21258  
calO1; orsellinic acid C3-O-methyltransferase [EC:2.1.1.-] [RN:R11416]
K21259  
calG3; calicheamicinone 4-hydroxyamino-4,6-dideoxy-alpha-D-glucosyltransferase [EC:2.4.1.-] [RN:R11417]
K21260  
calG2; calicheamicin 4-deoxy-4-thio-alpha-D-digitoxosyltransferase [EC:2.4.1.-] [RN:R11418]
K21261  
calO4; acyltransferase [RN:R11419]
K21262  
calG4; calicheamicin aminopentosyltransferase [EC:2.4.2.-] [RN:R11420 R11421]
K21263  
calG1; calicheamicin 3'-O-methyl-rhamnosyltransferase [EC:2.4.1.-] [RN:R11422 R11423]
Class
Pathway modules; Biosynthesis of terpenoids and polyketides; Enediyne biosynthesis
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R11412  
R11413  
R11414  
R11415  
R11416  
R11417  
R11418  
R11419  
R11420  
R11422  
R11423  
R11421  
Compound
C00083  Malonyl-CoA
C21343  Orsellinate-[acp]
C21344  2-Methoxyorsellinate-[acp]
C21345  5-Iodo-2-methoxyorsellinate-[acp]
C21346  3-Hydroxy-5-iodo-2-methoxyorsellinate-[acp]
C21347  5-Iodo-2,3-dimethoxyorsellinate-[acp]
C21337  Calicheamicinone
C21338  Calicheamicin T0
C21339  4-Deoxy-4-thio-alpha-D-digitoxosyl-calicheamicin T0
C21340  Calicheamicin PsAg
C21341  Calicheamicin alpha1(I)
C11469  Calicheamicin gamma(1)I
C21342  Calicheamicin alpha3(I)
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