KEGG   MODULE: M00849
Entry
M00849            Pathway   Module                                 
Name
C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Definition
K00626 K01641 (K00021,K00054) ((K00869 (K17942,(K25517+K09128 K25518+K03186))),(K18689 K18690 K22813)) K06981 K01823
Diagram
M00849

Orthology
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238]
K01641  
hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] [RN:R01978]
K00021  
hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34] [RN:R02082]
K00054  
hydroxymethylglutaryl-CoA reductase [EC:1.1.1.88] [RN:R02081]
K00869  
mevalonate kinase [EC:2.7.1.36] [RN:R02245]
K17942  
phosphomevalonate decarboxylase [EC:4.1.1.99] [RN:R10561]
K25517,K09128  
mevalonate 5-phosphate dehydratase [EC:4.2.1.182] [RN:R12894]
K25518,K03186  
trans-anhydromevalonate 5-phosphate decarboxylase [EC:4.1.1.126] [RN:R12895]
K18689  
mevalonate-3-kinase [EC:2.7.1.185] [RN:R10779]
K18690  
mevalonate-3-phosphate-5-kinase [EC:2.7.1.186] [RN:R10780]
K22813  
bisphosphomevalonate decarboxylase [EC:4.1.1.110] [RN:R10781]
K06981  
isopentenyl phosphate kinase [EC:2.7.4.26] [RN:R10093]
K01823  
isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2] [RN:R01123]
Class
Pathway modules; Biosynthesis of terpenoids and polyketides; Terpenoid backbone biosynthesis
Pathway
map00900  Terpenoid backbone biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R00238  
R01978  
R02082,R02081  
R02245  
R10561  
R12894  
R12895  
R10779  
R10780  
R10781  
R10093  
R01123  
Compound
C00024  Acetyl-CoA
C00332  Acetoacetyl-CoA
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00418  (R)-Mevalonate
C01107  (R)-5-Phosphomevalonate
C20345  Isopentenyl phosphate
C22453  trans-Anhydromevalonate phosphate
C20847  (R)-Mevalonate 3-phosphate
C20848  (R)-Mevalonate 3,5-bisphosphate
C00129  Isopentenyl diphosphate
C00235  Dimethylallyl diphosphate
Reference
PMID:28004831
  Authors
Vinokur JM, Cummins MC, Korman TP, Bowie JU
  Title
An Adaptation To Life In Acid Through A Novel Mevalonate Pathway.
  Journal
Sci Rep 6:39737 (2016)
DOI:10.1038/srep39737
Reference
PMID:24914732
  Authors
Vinokur JM, Korman TP, Cao Z, Bowie JU
  Title
Evidence of a novel mevalonate pathway in archaea.
  Journal
Biochemistry 53:4161-8 (2014)
DOI:10.1021/bi500566q
Reference
PMID:24375100
  Authors
Vannice JC, Skaff DA, Keightley A, Addo JK, Wyckoff GJ, Miziorko HM
  Title
Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an  archaeal alternate mevalonate pathway.
  Journal
J Bacteriol 196:1055-63 (2014)
DOI:10.1128/JB.01230-13
Reference
PMID:16621811
  Authors
Grochowski LL, Xu H, White RH
  Title
Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate.
  Journal
J Bacteriol 188:3192-8 (2006)
DOI:10.1128/JB.188.9.3192-3198.2006
Reference
PMID:30224495
  Authors
Hayakawa H, Motoyama K, Sobue F, Ito T, Kawaide H, Yoshimura T, Hemmi H.
  Title
Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate.
  Journal
Proc Natl Acad Sci U S A 115:10034-10039 (2018)
DOI:10.1073/pnas.1809154115
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