KEGG   MODULE: M00849
Entry
M00849            Pathway   Module                                 
Name
C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Definition
K00626 K01641 (K00021,K00054) ((K00869 (K17942,((K25517+K09128) (K25518+K03186)))),(K18689 K18690 K22813)) K06981 K01823
Diagram
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
M00849

Class
Pathway modules; Biosynthesis of terpenoids and polyketides; Terpenoid backbone biosynthesis
Pathway
map00900  Terpenoid backbone biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238]
K01641  
hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] [RN:R01978]
K00021  
hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34] [RN:R02082]
K00054  
hydroxymethylglutaryl-CoA reductase [EC:1.1.1.88] [RN:R02081]
K00869  
mevalonate kinase [EC:2.7.1.36] [RN:R02245]
K17942  
phosphomevalonate decarboxylase [EC:4.1.1.99] [RN:R10561]
K25517,K09128  
mevalonate 5-phosphate dehydratase [EC:4.2.1.182] [RN:R12894]
K25518,K03186  
trans-anhydromevalonate 5-phosphate decarboxylase [EC:4.1.1.126] [RN:R12895]
K18689  
mevalonate-3-kinase [EC:2.7.1.185] [RN:R10779]
K18690  
mevalonate-3-phosphate-5-kinase [EC:2.7.1.186] [RN:R10780]
K22813  
bisphosphomevalonate decarboxylase [EC:4.1.1.110] [RN:R10781]
K06981  
isopentenyl phosphate kinase [EC:2.7.4.26] [RN:R10093]
K01823  
isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2] [RN:R01123]
Complete
mja  Methanocaldococcus jannaschii
mfe  Methanocaldococcus fervens
mvu  Methanocaldococcus vulcanius
mfs  Methanocaldococcus sp. FS406-22
mif  Methanocaldococcus infernus
mjh  Methanocaldococcus bathoardescens
mesg  Methanocaldococcus lauensis SG7
mesa  Methanocaldococcus lauensis SG1
mig  Methanotorris igneus
mmp  Methanococcus maripaludis S2
mmq  Methanococcus maripaludis C5
mmx  Methanococcus maripaludis C6
mmz  Methanococcus maripaludis C7
mmd  Methanococcus maripaludis X1
mmak  Methanococcus maripaludis KA1
mmao  Methanococcus maripaludis OS7
mmad  Methanococcus maripaludis DSM 2067
mae  Methanococcus aeolicus
mvn  Methanococcus vannielii
mvo  Methanococcus voltae
mmvi  Methanococcus mangrovi
mok  Methanothermococcus okinawensis
meax  Methanothermococcus jasoni
metf  Methanofervidicoccus sp. A16
mth  Methanothermobacter thermautotrophicus
mmg  Methanothermobacter marburgensis
mwo  Methanothermobacter wolfeii
mtee  Methanothermobacter tenebrarum
metc  Methanothermobacter sp. CaT2
mete  Methanothermobacter sp. EMTCatA1
metz  Methanothermobacter sp. MT-2
metk  Methanothermobacter sp. KEPCO-1
mthm  Methanothermobacter sp. THM-1
metj  Methanothermobacter sp. THM-2
mst  Methanosphaera stadtmanae
metb  Methanosphaera sp. BMS
meis  Methanosphaera sp. ISO3-F5
mru  Methanobrevibacter ruminantium
msi  Methanobrevibacter smithii
meb  Methanobrevibacter sp. AbM4
mmil  Methanobrevibacter millerae
meye  Methanobrevibacter sp. YE315
mol  Methanobrevibacter olleyae
maro  Methanobrevibacter arboriphilus
metv  Methanobrevibacter sp. TLL-48-HuF1
mine  Methanobrevibacter intestini
mel  Methanobacterium lacus
mew  Methanobacterium paludis
meth  Methanobacterium sp. MB1
mfc  Methanobacterium formicicum BRM9
mfi  Methanobacterium formicicum DSM1535
mcub  Methanobacterium congolense
metn  Methanobacterium sp. MZ-A1
mett  Methanobacterium sp. BRmetb2
meto  Methanobacterium sp. BAmetb5
meme  Methanobacterium alkalithermotolerans
mfeg  Methanobacterium ferruginis
mrid  Methanobacterium aridiramus
mfv  Methanothermus fervidus
msoc  Methanothermus sociabilis
mka  Methanopyrus kandleri
afu  Archaeoglobus fulgidus DSM 4304
apo  Archaeoglobus profundus
ave  Archaeoglobus veneficus
ast  Archaeoglobus sulfaticallidus
fpl  Ferroglobus placidus
gac  Geoglobus acetivorans
gah  Geoglobus ahangari
pfu  Pyrococcus furiosus DSM 3638
pfi  Pyrococcus furiosus COM1
pho  Pyrococcus horikoshii
pab  Pyrococcus abyssi
pyn  Pyrococcus sp. NA2
pya  Pyrococcus yayanosii
pys  Pyrococcus sp. ST04
pyc  Pyrococcus kukulkanii
pwe  Pyrococcus woesei
tko  Thermococcus kodakarensis
ton  Thermococcus onnurineus
tga  Thermococcus gammatolerans
tsi  Thermococcus sibiricus
tba  Thermococcus barophilus
the  Thermococcus sp. 4557
tha  Thermococcus sp. AM4
thm  Thermococcus cleftensis
tlt  Thermococcus litoralis
ths  Thermococcus paralvinellae
tnu  Thermococcus nautili
teu  Thermococcus eurythermalis
tgy  Thermococcus guaymasensis
thv  Thermococcus sp. 2319x1
tch  Thermococcus chitonophagus
tpep  Thermococcus peptonophilus
tpie  Thermococcus piezophilus
tgg  Thermococcus gorgonarius
tce  Thermococcus celer
tbs  Thermococcus barossii
thh  Thermococcus sp. 5-4
tsl  Thermococcus siculi
ttd  Thermococcus thioreducens
tprf  Thermococcus profundus
trl  Thermococcus radiotolerans
tpaf  Thermococcus pacificus
thy  Thermococcus sp. P6
tic  Thermococcus indicus
tcq  Thermococcus camini
them  Thermococcus aciditolerans
thei  Thermococcus argininiproducens
tagg  Thermococcus aggregans
ppac  Palaeococcus pacificus
mba  Methanosarcina barkeri Fusaro
mby  Methanosarcina barkeri MS
mbw  Methanosarcina barkeri Wiesmoor
mbar  Methanosarcina barkeri 227
mbak  Methanosarcina barkeri 3
mac  Methanosarcina acetivorans
mma  Methanosarcina mazei Go1
mmj  Methanosarcina mazei S-6
mmac  Methanosarcina mazei C16
mvc  Methanosarcina vacuolata
mek  Methanosarcina sp. Kolksee
mls  Methanosarcina lacustris
metm  Methanosarcina sp. MTP4
mef  Methanosarcina sp. WH1
meq  Methanosarcina sp. WWM596
msj  Methanosarcina siciliae C2J
msz  Methanosarcina siciliae HI350
msw  Methanosarcina siciliae T4/M
mthr  Methanosarcina thermophila TM-1
mthe  Methanosarcina thermophila CHTI-55
mhor  Methanosarcina horonobensis
mfz  Methanosarcina flavescens
mhab  Methanosarcina hadiensis
mmaj  Methanosarcina mangrovi
msds  Methanosarcina sediminis
mbu  Methanococcoides burtonii
mmet  Methanococcoides methylutens
melo  Methanococcoides orientis
mmap  Methanococcoides mangrovi
mmh  Methanohalophilus mahii
mhaz  Methanohalophilus halophilus
mpot  Methanohalophilus portucalensis
mev  Methanohalobium evestigatum
mzh  Methanosalsum zhilinae
mpy  Methanolobus psychrophilus
mzi  Methanolobus zinderi
mmav  Methanolobus mangrovi
mseb  Methanolobus sediminis
mezk  Methanolobus sp. ZRKC1
mhz  Methanomethylovorans hollandica
mehf  Methanimicrococcus hongohii
mees  Methanimicrococcus stummii
mtp  Methanothrix thermoacetophila
mcj  Methanothrix soehngenii
mhi  Methanothrix harundinacea
mhu  Methanospirillum hungatei
mrtj  Methanospirillum purgamenti
mla  Methanocorpusculum labreanum
mem  Methanoculleus marisnigri
mbg  Methanoculleus bourgensis MS2
mchk  Methanoculleus chikugoensis
msum  Methanoculleus submarinus
mrc  Methanoculleus receptaculi
mpi  Methanolacinia petrolearia
mend  Methanoplanus endosymbiosus
mefw  Methanochimaera problematica
maqe  Methanofollis aquaemaris
mfk  Methanofollis formosanus
mou  Methanogenium organophilum
mesb  Methanogenium sp. S4BF
manq  Methanomicrobium antiquum
mbn  Methanoregula boonei
mfo  Methanoregula formicica
mpl  Methanosphaerula palustris
mpd  Methanocella paludicola
mez  Methanocella conradii
rci  Methanocella arvoryzae
hal  Halobacterium salinarum NRC-1
hsl  Halobacterium salinarum R1
hanr  Halobacterium salinarum NRC-34001
hdl  Halobacterium sp. DL1
hhb  Halobacterium hubeiense
hags  Halobacterium sp. GSL-19
habo  Halobacterium sp. BOL4-2
hno  Halobacterium noricense
hlu  Halobacterium litoreum
hanx  Halobacterium sp. NMX12-1
halh  Halodesulfurarchaeum formicicum HTSR1
hhsr  Halodesulfurarchaeum formicicum HSR6
hsu  Halanaeroarchaeum sulfurireducens HSR2
hsf  Halanaeroarchaeum sulfurireducens M27-SA2
hahs  Halanaeroarchaeum sp. HSR-CO
salr  Salarchaeum sp. JOR-1
halr  Halarchaeum sp. CBA1220
hje  Halalkalicoccus jeotgali
hdo  Halococcus dombrowskii
halx  Halorussus limi
haxz  Halorussus gelatinilyticus
hayc  Halorussus salilacus
haxy  Halorussus vallis
sali  Salinarchaeum sp. Harcht-Bsk1
saim  Salinarchaeum sp. IM2453
hara  Natranaeroarchaeum sulfidigenes
hma  Haloarcula marismortui ATCC 43049
hsin  Haloarcula marismortui ATCC 33800
hhi  Haloarcula hispanica ATCC 33960
hhn  Haloarcula hispanica N601
hab  Haloarcula sp. CBA1115
hta  Haloarcula taiwanensis
halj  Haloarcula sp. JP-L23
hsaa  Haloarcula salina
hut  Halorhabdus utahensis
hti  Halorhabdus tiamatea
hala  Halorhabdus sp. CBA1104
hasv  Halorhabdus sp. SVX81
habn  Halorhabdus sp. BNX81
hmu  Halomicrobium mukohataei
halz  Halomicrobium mukohataei JP60
hall  Halomicrobium sp. LC1Hm
hazp  Halomicrobium sp. ZPS1
hali  Halorientalis sp. IM1011
hpal  Halorientalis pallida
hsn  Halapricum salinum
hds  Halapricum desulfuricans
hrr  Halosimplex rubrum
hpel  Halosimplex pelagicum
hlt  Halosimplex litoreum
harc  Halococcoides cellulosivorans
ssai  Salinirubellus salinus
haad  Halocatena salina
nph  Natronomonas pharaonis
nmo  Natronomonas moolapensis
nho  Natronomonas halophila
nsal  Natronomonas salina
hwa  Haloquadratum walsbyi DSM 16790
hwc  Haloquadratum walsbyi C23
hvo  Haloferax volcanii DS2
hale  Haloferax volcanii wsp1
hln  Haloferax volcanii SVX82
hme  Haloferax mediterranei
hgi  Haloferax gibbonsii
hls  Haloferax larsenii
hdr  Haloferax denitrificans
hbo  Halogeometricum borinquense
haq  Haloplanus rubicundus CBA1112
haj  Haloplanus rubicundus CBA1113
haer  Haloplanus aerogenes
hra  Haloplanus rallus
hrl  Haloplanus ruber
hlm  Halobellus limi
halm  Haloprofundus sp. MHR1
hla  Halorubrum lacusprofundi
halp  Halorubrum sp. PV6
halb  Halorubrum sp. BOL3-1
hezz  Halorubrum ezzemoulense
halq  Halorubrum sp. CBA1229
hss  Halorubrum ruber
hsai  Halorubrum salinarum
hazz  Halorubrum sp. 2020YC2
htp  Halorubrum trapanicum
hxj  Halorubrum xinjiangense
srub  Salinigranum rubrum
hae  Halohasta litchfieldiae
haln  Halolamina sp. CBA1230
halg  Halorarum halophilum
halu  Halorarum salinum
hmp  Halobaculum magnesiiphilum
hre  Halobaculum roseum
hrm  Halobaculum rubrum
hacb  Halobaculum sp. CBA1158
hdf  Halalkaliarchaeum desulfuricum
haaa  Halalkaliarchaeum sp. AArc-CO
hah  Halophilic archaeon
htu  Haloterrigena turkmenica
hsal  Haloterrigena salifodinae
hakz  Haloterrigena alkaliphila
nmg  Natrialba magadii
hxa  Halopiger xanaduensis
nat  Natrinema gari
npe  Natrinema pellirubrum
nvr  Natrinema versiforme
npl  Natrinema pallidum
nay  Natrinema zhouii
haly  Natrinema halophilum
hjt  Natrinema thermotolerans
hlo  Natrinema longum
nge  Natronobacterium gregoryi
hlc  Natronobacterium lacisalsi
hru  Halovivax ruber
sawl  Natronosalvus rutilus
halv  Natronosalvus halobius
nou  Natronococcus occultus
hlr  Halostagnicola larsenii
naj  Natrarchaeobaculum aegyptiacum
nag  Natrarchaeobaculum sulfurireducens AArc-Mg
nan  Natrarchaeobaculum sulfurireducens AArc1
nara  Natrialbaceae archaeon AArc-T1-2
nbg  Natronorubrum bangense
nas  Natronorubrum aibiense
hda  Natronorubrum daqingense
meam  Methanonatronarchaeum sp. AMET6-2
tac  Thermoplasma acidophilum
tvo  Thermoplasma volcanium
omr  Oxyplasma meridianum
pto  Picrophilus oshimae
fac  Ferroplasma acidarmanus
fai  Ferroplasma acidiphilum
cdiv  Cuniculiplasma divulgatum
tar  Thermoplasmatales archaeon BRNA1
max  Methanomethylophilus alvi
mer  Methanomassiliicoccus intestinalis Issoire-Mx1
mear  Methanoplasma termitum
meuz  Methanogranum gryphiswaldense
marc  Methanogenic archaeon ISO4-H5
abi  Aciduliprofundum boonei
acf  Aciduliprofundum sp. MAR08-339
smr  Staphylothermus marinus
shc  Staphylothermus hellenicus
iho  Ignicoccus hospitalis
iis  Ignicoccus islandicus
dka  Desulfurococcus amylolyticus 1221n
dfd  Desulfurococcus amylolyticus DSM 16532
dmu  Desulfurococcus mucosus
tag  Thermosphaera aggregans
tcs  Thermosphaera chiliense
iag  Ignisphaera aggregans
thg  Thermogladius calderae
hbu  Hyperthermus butylicus
pfm  Pyrolobus fumarii
pdl  Pyrodictium delaneyi
pabi  Pyrodictium abyssi
pare  Pyrofollis japonicus
pai  Pyrobaculum aerophilum
pis  Pyrobaculum islandicum
pcl  Pyrobaculum calidifontis
pas  Pyrobaculum arsenaticum
pog  Pyrobaculum oguniense
tne  Pyrobaculum neutrophilum
pyw  Pyrobaculum sp. WP30
cma  Caldivirga maquilingensis
ttn  Thermoproteus tenax
tuz  Thermoproteus uzoniensis
vdi  Vulcanisaeta distributa
vmo  Vulcanisaeta moutnovskia
vso  Vulcanisaeta souniana
asc  Acidilobus saccharovorans
acia  Acidilobus sp. 7A
clg  Caldisphaera lagunensis
ape  Aeropyrum pernix
acj  Aeropyrum camini
ffo  Fervidicoccus fontis
mvj  Methanosuratincola verstraetei
nmr  Nitrosopumilus maritimus
nir  Nitrosopumilus sediminis
nkr  Nitrosopumilus koreensis
nid  Nitrosopumilus piranensis
nin  Nitrosopumilus adriaticus
niw  Nitrosopumilus sp. SW
ncl  Nitrosopumilus cobalaminigenes
nox  Nitrosopumilus oxyclinae
nip  Nitrosopumilus sp. K4
nzt  Nitrosopumilus zosterae
nct  Nitrosomarinus catalinensis
nic  Nitrosarchaeum sp. AC2
nga  Nitrososphaera gargensis
nvn  Nitrososphaera viennensis
nev  Nitrososphaera evergladensis
taa  Nitrosocosmicus oleophilus
nfn  Nitrosocosmicus franklandianus
ncv  Nitrosocaldus cavascurensis
ndv  Nitrosotalea devaniterrae
csu  Caldarchaeum subterraneum
ccai  Conexivisphaera calida
nbv  Nitrosopelagicus brevis
tah  Nitrosotenuis cloacae
niu  Nitrosotenuis sp. DW1
barc  Bathyarchaeota archaeon BA1
marh  Mancarchaeum acidiphilum Mia14
flt  Fermentimicrarchaeum limneticum
loki  Lokiarchaeum sp. GC14_75
 » show all
Reaction
R00238  
R01978  
R02082,R02081  
R02245  
R10561  
R12894  
R12895  
R10779  
R10780  
R10781  
R10093  
R01123  
Compound
C00024  Acetyl-CoA
C00332  Acetoacetyl-CoA
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00418  (R)-Mevalonate
C01107  (R)-5-Phosphomevalonate
C20345  Isopentenyl phosphate
C22453  trans-Anhydromevalonate phosphate
C20847  (R)-Mevalonate 3-phosphate
C20848  (R)-Mevalonate 3,5-bisphosphate
C00129  Isopentenyl diphosphate
C00235  Dimethylallyl diphosphate
Reference
PMID:28004831
  Authors
Vinokur JM, Cummins MC, Korman TP, Bowie JU
  Title
An Adaptation To Life In Acid Through A Novel Mevalonate Pathway.
  Journal
Sci Rep 6:39737 (2016)
DOI:10.1038/srep39737
Reference
PMID:24914732
  Authors
Vinokur JM, Korman TP, Cao Z, Bowie JU
  Title
Evidence of a novel mevalonate pathway in archaea.
  Journal
Biochemistry 53:4161-8 (2014)
DOI:10.1021/bi500566q
Reference
PMID:24375100
  Authors
Vannice JC, Skaff DA, Keightley A, Addo JK, Wyckoff GJ, Miziorko HM
  Title
Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an  archaeal alternate mevalonate pathway.
  Journal
J Bacteriol 196:1055-63 (2014)
DOI:10.1128/JB.01230-13
Reference
PMID:16621811
  Authors
Grochowski LL, Xu H, White RH
  Title
Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate.
  Journal
J Bacteriol 188:3192-8 (2006)
DOI:10.1128/JB.188.9.3192-3198.2006
Reference
PMID:30224495
  Authors
Hayakawa H, Motoyama K, Sobue F, Ito T, Kawaide H, Yoshimura T, Hemmi H.
  Title
Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate.
  Journal
Proc Natl Acad Sci U S A 115:10034-10039 (2018)
DOI:10.1073/pnas.1809154115
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