KEGG   MODULE: M00893
Entry
M00893            Pathway   Module                                 
Name
Lovastatin biosynthesis, malonyl-CoA => lovastatin acid
Definition
K20981 K20982 K20985 K20980
K20984
K20983
Diagram
M00893

Orthology
K20981  
LOVB; lovastatin nonaketide synthase [EC:2.3.1.161] [RN:R07251]
K20982  
LOVC; lovastatin enoyl reductase [EC:2.3.1.161] [RN:R07251]
K20985  
LOVG; dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase [EC:3.1.2.31] [RN:R11187]
K20980  
LOVA; dihydromonacolin L/monacolin L hydroxylase [EC:1.14.14.124 1.14.14.125] [RN:R10791 R10792 R10794]
K20984  
LOVF; 2-methylbutanoate polyketide synthase [EC:2.3.1.244] [RN:R11445]
K20983  
LOVD; monacolin J acid methylbutanoate transferase [EC:2.3.1.238] [RN:R11126]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other fungal compounds
Pathway
map00997  Biosynthesis of various other secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C00083  Malonyl-CoA
C21108  Dihydromonacolin L-[acyl-carrier protein]
C10851  Calystegin B2
C20852  3alpha-Hydroxy-3,5-dihydromonacolin L acid
C20853  Monacolin L acid
C20854  Monacolin J acid
C21129  (S)-2-Methylbutanoyl-[acp]
C21130  Lovastatin acid
Reference
  Authors
Xu W, Chooi YH, Choi JW, Li S, Vederas JC, Da Silva NA, Tang Y
  Title
LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.
  Journal
Angew Chem Int Ed Engl 52:6472-5 (2013)
DOI:10.1002/anie.201302406
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