KEGG   MODULE: M00902
Entry
M00902            Pathway   Module                                 
Name
Podophyllotoxin biosynthesis, coniferyl alcohol => podophyllotoxin
Definition
K21568 K19650 K21207 K21203 K21205 K21204 K21202
Diagram
M00902  Podophyllotoxin biosynthesis, coniferyl alcohol => podophyllotoxin
M00902

Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of phytochemical compounds
Pathway
map00999  Biosynthesis of various plant secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K21568  
pinoresinol/lariciresinol reductase [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4] [RN:R10225 R10226]
K19650  
secoisolariciresinol dehydrogenase [EC:1.1.1.331] [RN:R10129]
K21207  
(-)-pluviatolide synthase [EC:1.14.19.72] [RN:R11222]
K21203  
(-)-pluviatolide 4-O-methyltransferase [EC:2.1.1.323] [RN:R11230]
K21205  
bursehernin 5'-monooxygenase [EC:1.14.14.131] [RN:R11211]
K21204  
5'-demethylyatein 5'-O-methyltransferase [EC:2.1.1.330] [RN:R11545]
K21202  
(-)-deoxypodophyllotoxin synthase [EC:1.14.20.8] [RN:R11210]
Complete
93608  Sinopodophyllum hexandrum
Reaction
R12126  
R10225  
R10226  
R10129  
R11222  
R11230  
R11211  
R11545  
R11210  
R12127  
Compound
C00590  Coniferyl alcohol
C05366  (+)-Pinoresinol
C10646  Lariciresinol
C18167  Secoisolariciresinol
C10682  Matairesinol
C21191  Pluviatolide
C21183  Bursehernin
C21184  (-)-5'-Demethylyatein
C10577  Casimiroedine
C10556  Deoxypodophyllotoxin
C10874  Podophyllotoxin
Reference
PMID:26359402
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
Reference
PMID:27314513
  Authors
Yang L, Sun P, Li MF
  Title
Chilling temperature stimulates growth, gene over-expression and podophyllotoxin biosynthesis in Podophyllum hexandrum Royle.
  Journal
Plant Physiol Biochem 107:197-203 (2016)
DOI:10.1016/j.plaphy.2016.06.010
LinkDB

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