| Entry |
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| Name |
Mutation-activated KIT to RAS-ERK signaling pathway
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| Definition |
KIT* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK |
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| Expanded |
3815v1 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 3815 | KIT; KIT proto-oncogene receptor tyrosine kinase |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
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| Variant |
3815v1 (KIT*) KIT kinase domain mutation
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| Reference |
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| Authors |
Liang J, Wu YL, Chen BJ, Zhang W, Tanaka Y, Sugiyama H |
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| Title |
The C-kit receptor-mediated signal transduction and tumor-related diseases. |
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| Journal |
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| Reference |
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| Authors |
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R. |
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| Title |
Normal and oncogenic forms of the receptor tyrosine kinase kit. |
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| Journal |
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| Reference |
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| Authors |
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H. |
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| Title |
The molecular pathogenesis of acute myeloid leukemia. |
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| Journal |
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| Reference |
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| Authors |
Stirewalt DL, Meshinchi S, Radich JP |
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| Title |
Molecular targets in acute myelogenous leukemia. |
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| Journal |
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| LinkDB |
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