| Entry |
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| Name |
Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
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| Definition |
FLT3* -> GRB2 -> SOS -> RAS -> PI3K -> PIP3 -> AKT -| BAD |
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| Expanded |
(2322v2,2322v1) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572 |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 2322 | FLT3; fms related tyrosine kinase 3 |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 572 | BAD; BCL2 associated agonist of cell death |
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| Variant |
2322v2 (FLT3*) FLT3 internal tandem duplication (ITD)
2322v1 (FLT3*) FLT3 kinase domain mutation
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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| Reference |
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| Authors |
Stirewalt DL, Radich JP. |
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| Title |
The role of FLT3 in haematopoietic malignancies. |
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| Journal |
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| Reference |
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| Authors |
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L. |
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| Title |
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. |
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| Journal |
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| LinkDB |
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