| Entry |
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| Name |
FLT3LG-FLT3-RAS-ERK signaling pathway
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| Definition |
FLT3LG -> FLT3 -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK |
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| Expanded |
2323 -> 2322 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 2323 | FLT3LG; fms related tyrosine kinase 3 ligand |
| 2322 | FLT3; fms related tyrosine kinase 3 |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
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| Reference |
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| Authors |
Grafone T, Palmisano M, Nicci C, Storti S |
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| Title |
An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: biology and treatment. |
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| Journal |
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| Reference |
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| Authors |
Stirewalt DL, Radich JP. |
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| Title |
The role of FLT3 in haematopoietic malignancies. |
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| Journal |
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| Reference |
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| Authors |
Gocek E, Studzinski GP |
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| Title |
The Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia Therapy. |
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| Journal |
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| Reference |
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| Authors |
Weisberg E, Barrett R, Liu Q, Stone R, Gray N, Griffin JD |
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| Title |
FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML. |
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| Journal |
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| LinkDB |
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