KEGG   NETWORK: N00367
Entry
N00367                      Network                                
Name
HPV E5 to EGFR-RAS-ERK signaling pathway
Definition
E5 -| V-ATPase -| EGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
K21812 -| 527 -| 1956 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Type
Pathogen
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
527  ATP6V0C; ATPase H+ transporting V0 subunit c
1956  EGFR; epidermal growth factor receptor
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Perturbant
K21812 (E5)  E5; HPV protein E5
Reference
PMID:20592731
  Authors
Moody CA, Laimins LA
  Title
Human papillomavirus oncoproteins: pathways to transformation.
  Journal
Nat Rev Cancer 10:550-60 (2010)
DOI:10.1038/nrc2886
Reference
PMID:28545552
  Authors
de Freitas AC, de Oliveira THA, Barros MR Jr, Venuti A
  Title
hrHPV E5 oncoprotein: immune evasion and related immunotherapies.
  Journal
J Exp Clin Cancer Res 36:71 (2017)
DOI:10.1186/s13046-017-0541-1
Reference
PMID:22499770
  Authors
Sandberg A, Lindell G, Kallstrom BN, Branca RM, Danielsson KG, Dahlberg M, Larson B, Forshed J, Lehtio J
  Title
Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.
  Journal
Mol Cell Proteomics 11:M112.016998 (2012)
DOI:10.1074/mcp.M112.016998
Reference
PMID:22078316
  Authors
Venuti A, Paolini F, Nasir L, Corteggio A, Roperto S, Campo MS, Borzacchiello G
  Title
Papillomavirus E5: the smallest oncoprotein with many functions.
  Journal
Mol Cancer 10:140 (2011)
DOI:10.1186/1476-4598-10-140
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