KEGG   NETWORK: N00446
Entry
N00446                      Network                                
Name
TNF-JNK signaling pathway
Definition
TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> (TAK1+TAB1/2) -> MKK4/7 -> JNK -> AP1
  Expanded
7124 -> 7132 -> (8737+8717+(7186,7188)) -> (6885+(10454,23118)) -> (6416,5609) -> (5599,5601,5602) -> (2353,3725)
Class
nt06516 TNF signaling
nt06223 TNF signaling (cancer)
nt06461 Huntington disease
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
nt06161 Human immunodeficiency virus 1 (HIV-1)
nt06180 Pathogenic Escherichia coli
nt06181 Salmonella
Type
Reference
Pathway
hsa04668  TNF signaling pathway
Gene
7124  TNF; tumor necrosis factor
7132  TNFRSF1A; TNF receptor superfamily member 1A
8737  RIPK1; receptor interacting serine/threonine kinase 1
8717  TRADD; TNFRSF1A associated via death domain
7186  TRAF2; TNF receptor associated factor 2
7188  TRAF5; TNF receptor associated factor 5
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
10454  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
6416  MAP2K4; mitogen-activated protein kinase kinase 4
5609  MAP2K7; mitogen-activated protein kinase kinase 7
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
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