| Entry |
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| Name |
HBV HBx to RAS-ERK signaling pathway
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| Definition |
X -> SRC -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> ELK1 |
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| Expanded |
K21854 -> 6714 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 2002 |
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| Class |
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| Type |
Pathogen
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| Pathway |
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| Disease |
| H00048 | Hepatocellular carcinoma |
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| Gene |
| 6714 | SRC; SRC proto-oncogene, non-receptor tyrosine kinase |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
| 2002 | ELK1; ETS transcription factor ELK1 |
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| Perturbant |
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| Reference |
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| Authors |
Zhang X, Zhang H, Ye L |
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| Title |
Effects of hepatitis B virus X protein on the development of liver cancer. |
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| Journal |
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| Reference |
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| Authors |
Klein NP, Schneider RJ |
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| Title |
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras. |
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| Journal |
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| Reference |
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| Authors |
Panteva M, Korkaya H, Jameel S |
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| Title |
Hepatitis viruses and the MAPK pathway: is this a survival strategy? |
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| Journal |
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| LinkDB |
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