KEGG   NETWORK: N00994
Entry
N00994                      Network                                
Name
AGE-RAGE signaling pathway
Definition
AGE -> AGER -> RAS -> RAF -> MEK -> ERK -> NFKB => (TNF,IL6,NOS2)
  Expanded
(C21011,C21012,C21013,C21014) -> 177 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> (4790+5970) => (7124,3569,4843)
Class
nt06460 Alzheimer disease
nt06466 Pathways of neurodegeneration
Type
Reference
Gene
177  AGER; advanced glycosylation end-product specific receptor
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
7124  TNF; tumor necrosis factor
3569  IL6; interleukin 6
4843  NOS2; nitric oxide synthase 2
Metabolite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23296615
  Authors
Rouhiainen A, Kuja-Panula J, Tumova S, Rauvala H
  Title
RAGE-mediated cell signaling.
  Journal
Methods Mol Biol 963:239-63 (2013)
DOI:10.1007/978-1-62703-230-8_15
Reference
PMID:21590515
  Authors
Zong H, Ward M, Stitt AW
  Title
AGEs, RAGE, and diabetic retinopathy.
  Journal
Curr Diab Rep 11:244-52 (2011)
DOI:10.1007/s11892-011-0198-7
Reference
PMID:24624331
  Authors
Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T, Simm A
  Title
Role of advanced glycation end products in cellular signaling.
  Journal
Redox Biol 2:411-29 (2014)
DOI:10.1016/j.redox.2013.12.016
Reference
PMID:23838007
  Authors
Xie J, Mendez JD, Mendez-Valenzuela V, Aguilar-Hernandez MM
  Title
Cellular signalling of the receptor for advanced glycation end products (RAGE).
  Journal
Cell Signal 25:2185-97 (2013)
DOI:10.1016/j.cellsig.2013.06.013
Reference
PMID:16894049
  Authors
Goldin A, Beckman JA, Schmidt AM, Creager MA
  Title
Advanced glycation end products: sparking the development of diabetic vascular injury.
  Journal
Circulation 114:597-605 (2006)
DOI:10.1161/CIRCULATIONAHA.106.621854
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