KEGG   NETWORK: N00996
Entry
N00996                      Network                                
Name
Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
Definition
APP* -> Abeta -> AGER -> RAS -> RAF -> MEK -> ERK -> NFKB => (TNF,IL6,NOS2)
  Expanded
351v1 -> (C16515,C16514) -> 177 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> (4790+5970) => (7124,3569,4843)
Class
nt06460 Alzheimer disease
nt06466 Pathways of neurodegeneration
Type
Variant
Pathway
hsa05010  Alzheimer disease
Disease
H00056  Alzheimer disease
Gene
351  APP; amyloid beta precursor protein
177  AGER; advanced glycosylation end-product specific receptor
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
7124  TNF; tumor necrosis factor
3569  IL6; interleukin 6
4843  NOS2; nitric oxide synthase 2
Variant
351v1 (APP*)  APP mutation
Metabolite
C16515  Beta-amyloid protein 42
C16514  Beta-amyloid protein 40
Reference
PMID:11484003
  Authors
Small DH, Mok SS, Bornstein JC
  Title
Alzheimer's disease and Abeta toxicity: from top to bottom.
  Journal
Nat Rev Neurosci 2:595-8 (2001)
DOI:10.1038/35086072
Reference
PMID:19464758
  Authors
Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Munch G
  Title
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.
  Journal
Neurobiol Aging 32:763-77 (2011)
DOI:10.1016/j.neurobiolaging.2009.04.016
Reference
PMID:19903023
  Authors
Origlia N, Arancio O, Domenici L, Yan SS
  Title
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.
  Journal
Expert Rev Neurother 9:1635-45 (2009)
DOI:10.1586/ern.09.107
Reference
PMID:19221410
  Authors
Origlia N, Capsoni S, Cattaneo A, Fang F, Arancio O, Yan SD, Domenici L
  Title
Abeta-dependent Inhibition of LTP in different intracortical circuits of the visual cortex: the role of RAGE.
  Journal
J Alzheimers Dis 17:59-68 (2009)
DOI:10.3233/JAD-2009-1045
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