KEGG   NETWORK: N01301
Entry
N01301                      Network                                
Name
Salmonella SifA to Tethering of late endosomes and lysosomes
Definition
SifA == PLEKHM1 == RAB7 == HOPS
  Expanded
K15347 == 9842 == (7879,338382) == (23339+27072+55823+57617+64601+65082)
Class
nt06125 Membrane trafficking (bacteria)
Type
Pathogen
Pathway
hsa05132  Salmonella infection
Disease
H00113  Salmonellosis
Gene
9842  PLEKHM1; pleckstrin homology and RUN domain containing M1
7879  RAB7A; RAB7A, member RAS oncogene family
338382  RAB7B; RAB7B, member RAS oncogene family
23339  VPS39; VPS39 subunit of HOPS complex
27072  VPS41; VPS41 subunit of HOPS complex
55823  VPS11; VPS11 core subunit of CORVET and HOPS complexes
57617  VPS18; VPS18 core subunit of CORVET and HOPS complexes
64601  VPS16; VPS16 core subunit of CORVET and HOPS complexes
65082  VPS33A; VPS33A core subunit of CORVET and HOPS complexes
Perturbant
K15347 (SifA)  sifA; secreted effector protein SifA
Reference
  Authors
McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS, Rajalingam K, Macek B, Holden DW, Bumann D, Dikic I
  Title
PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.
  Journal
Cell Host Microbe 17:58-71 (2015)
DOI:10.1016/j.chom.2014.11.011
Reference
  Authors
McEwan DG, Dikic I
  Title
PLEKHM1: Adapting to life at the lysosome.
  Journal
Autophagy 11:720-2 (2015)
DOI:10.1080/15548627.2015.1034419
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