KEGG   NETWORK: N01308
Entry
N01308                      Network                                
Name
MDA5-IRF7/3 signaling pathway
Definition
RNA -> (MDA5,ZNFX1) -> MAVS -> TRAF3 -> (TANK+NAP1+SINTBAD) -> (TBK1+IKBKE) -> (IRF7,IRF3) => (IFNA,IFNB1)
  Expanded
C00046 -> (64135,57169) -> 57506 -> 7187 -> (10010+64343+9755) -> (29110+9641) -> (3665,3661) => ((3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452),3456)
Class
nt06519 RLR signaling
nt06171 SARS coronavirus 2 (SARS-CoV-2)
Type
Reference
Pathway
hsa04622  RIG-I-like receptor signaling pathway
Gene
64135  IFIH1; interferon induced with helicase C domain 1
57169  ZNFX1; zinc finger NFX1-type containing 1
57506  MAVS; mitochondrial antiviral signaling protein
7187  TRAF3; TNF receptor associated factor 3
10010  TANK; TRAF family member associated NFKB activator
64343  AZI2; 5-azacytidine induced 2
9755  TBKBP1; TBK1 binding protein 1
29110  TBK1; TANK binding kinase 1
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon
3665  IRF7; interferon regulatory factor 7
3661  IRF3; interferon regulatory factor 3
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
Metabolite
C00046  RNA
Reference
PMID:32203325
  Authors
Rehwinkel J, Gack MU
  Title
RIG-I-like receptors: their regulation and roles in RNA sensing.
  Journal
Nat Rev Immunol 20:537-551 (2020)
DOI:10.1038/s41577-020-0288-3
Reference
PMID:18272355
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
PMID:23758787
  Authors
Xie P
  Title
TRAF molecules in cell signaling and in human diseases.
  Journal
J Mol Signal 8:7 (2013)
DOI:10.1186/1750-2187-8-7
Reference
PMID:35087521
  Authors
Guillemin A, Kumar A, Wencker M, Ricci EP
  Title
Shaping the Innate Immune Response Through Post-Transcriptional Regulation of Gene Expression Mediated by RNA-Binding Proteins.
  Journal
Front Immunol 12:796012 (2021)
DOI:10.3389/fimmu.2021.796012
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