Entry
Name
NNK/NNN to RAS-ERK signaling pathway
Definition
(NNK,NNN) -> CHRN -> Ca2+ -> RAS -> RAF -> MEK -> ERK -> (FOS,JUN,MYC,BCL2)
Expanded
(C16453,C16452) -> (1139,(1137+1141),(1136+1143),(1136+1141) -> C00076 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> (2353,3725,4609,596)
Class
Type
Env factor
Pathway
hsa05207 Chemical carcinogenesis - receptor activation
Disease
H00014 Non-small cell lung cancer
Gene
1139 CHRNA7; cholinergic receptor nicotinic alpha 7 subunit
1137 CHRNA4; cholinergic receptor nicotinic alpha 4 subunit
1141 CHRNB2; cholinergic receptor nicotinic beta 2 subunit
1136 CHRNA3; cholinergic receptor nicotinic alpha 3 subunit
1143 CHRNB4; cholinergic receptor nicotinic beta 4 subunit
3265 HRAS; HRas proto-oncogene, GTPase
3845 KRAS; KRAS proto-oncogene, GTPase
4893 NRAS; NRAS proto-oncogene, GTPase
369 ARAF; A-Raf proto-oncogene, serine/threonine kinase
673 BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604 MAP2K1; mitogen-activated protein kinase kinase 1
5605 MAP2K2; mitogen-activated protein kinase kinase 2
5594 MAPK1; mitogen-activated protein kinase 1
5595 MAPK3; mitogen-activated protein kinase 3
2353 FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit
4609 MYC; MYC proto-oncogene, bHLH transcription factor
596 BCL2; BCL2 apoptosis regulator
Perturbant
C16453 (NNK) 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16452 (NNN) N'-Nitrosonornicotine
Metabolite
Reference
Authors
Wu CH, Lee CH, Ho YS
Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
Journal
Reference
Authors
Improgo MR, Tapper AR, Gardner PD
Title
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.
Journal
Reference
Authors
Jin Z, Gao F, Flagg T, Deng X
Title
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation.
Journal
LinkDB
All DBs