KEGG   NETWORK: N01344
Entry
N01344                      Network                                

Name
NNK/NNN to RAS-ERK signaling pathway
Definition
(NNK,NNN) -> CHRN -> Ca2+ -> RAS -> RAF -> MEK -> ERK -> (FOS,JUN,MYC,BCL2)
  Expanded
(C16453,C16452) -> (1139,(1137+1141),(1136+1143),(1136+1141) -> C00076 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> (2353,3725,4609,596)
Class
nt06210 ERK signaling
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00014  Non-small cell lung cancer
H00013  Small cell lung cancer
Gene
1139  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit
1137  CHRNA4; cholinergic receptor nicotinic alpha 4 subunit
1141  CHRNB2; cholinergic receptor nicotinic beta 2 subunit
1136  CHRNA3; cholinergic receptor nicotinic alpha 3 subunit
1143  CHRNB4; cholinergic receptor nicotinic beta 4 subunit
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit
4609  MYC; MYC proto-oncogene, bHLH transcription factor
596  BCL2; BCL2 apoptosis regulator
Perturbant
C16453 (NNK)  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16452 (NNN)  N'-Nitrosonornicotine
Metabolite
C00076  Calcium cation
Reference
  Authors
Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
  Journal
Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
Reference
  Authors
Improgo MR, Tapper AR, Gardner PD
  Title
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.
  Journal
Biochem Pharmacol 82:1015-21 (2011)
DOI:10.1016/j.bcp.2011.05.020
Reference
  Authors
Jin Z, Gao F, Flagg T, Deng X
  Title
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation.
  Journal
J Biol Chem 279:40209-19 (2004)
DOI:10.1074/jbc.M404056200
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