KEGG   NETWORK: N01361
Entry
N01361                      Network                                
Name
P4/MPA to PR-RAS-ERK signaling pathway
Definition
(P4,MPA) -> (PGR+SRC) -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> CCND1
  Expanded
(C00410,C08150) -> (5241+6714) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 595
Class
nt06210 ERK signaling (cancer)
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00031  Breast cancer
Gene
5241  PGR; progesterone receptor
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
595  CCND1; cyclin D1
Perturbant
C00410 (P4)  Progesterone
C08150 (MPA)  Medroxyprogesterone acetate
Reference
PMID:29146555
  Authors
Boonyaratanakornkit V, Hamilton N, Marquez-Garban DC, Pateetin P, McGowan EM, Pietras RJ
  Title
Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer.
  Journal
Mol Cell Endocrinol 466:51-72 (2018)
DOI:10.1016/j.mce.2017.11.010
Reference
PMID:18321550
  Authors
Boonyaratanakornkit V, Bi Y, Rudd M, Edwards DP
  Title
The role and mechanism of progesterone receptor activation of extra-nuclear signaling pathways in regulating gene transcription and cell cycle progression.
  Journal
Steroids 73:922-8 (2008)
DOI:10.1016/j.steroids.2008.01.010
Reference
PMID:11545730
  Authors
Boonyaratanakornkit V, Scott MP, Ribon V, Sherman L, Anderson SM, Maller JL, Miller WT, Edwards DP
  Title
Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases.
  Journal
Mol Cell 8:269-80 (2001)
DOI:10.1016/s1097-2765(01)00304-5
Reference
PMID:12612073
  Authors
Ballare C, Uhrig M, Bechtold T, Sancho E, Di Domenico M, Migliaccio A, Auricchio F, Beato M
  Title
Two domains of the progesterone receptor interact with the estrogen receptor and are required for progesterone activation of the c-Src/Erk pathway in mammalian cells.
  Journal
Mol Cell Biol 23:1994-2008 (2003)
DOI:10.1128/mcb.23.6.1994-2008.2003
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