KEGG   NETWORK: N01464
Entry
N01464                      Network                                
Name
Fanconi anemia pathway
Definition
FANCM+TOPBP1+MHF+FAAP24 -> ATR -> FAcore == FANCL+UBE2T -> FANCD2+FANCI+Ub
  Expanded
57697+11073+378708+201254+91442 -> 545 -> 2175+2187+2176+2178+2188+2189+199990+80233 == 55120+29089 -> 2177+55215+7314
Class
nt06508 Interstrand crosslink repair
Type
Reference
Pathway
hsa03460  Fanconi anemia pathway
Gene
57697  FANCM; FA complementation group M
11073  TOPBP1; DNA topoisomerase II binding protein 1
378708  CENPS; centromere protein S
201254  CENPX; centromere protein X
91442  FAAP24; FA core complex associated protein 24
545  ATR; ATR serine/threonine kinase
2175  FANCA; FA complementation group A
2187  FANCB; FA complementation group B
2176  FANCC; FA complementation group C
2178  FANCE; FA complementation group E
2188  FANCF; FA complementation group F
2189  FANCG; FA complementation group G
199990  FAAP20; FA core complex associated protein 20
80233  FAAP100; FA core complex associated protein 100
55120  FANCL; FA complementation group L
29089  UBE2T; ubiquitin conjugating enzyme E2 T
2177  FANCD2; FA complementation group D2
55215  FANCI; FA complementation group I
7314  UBB; ubiquitin B
Reference
PMID:27037238
  Authors
Michl J, Zimmer J, Tarsounas M
  Title
Interplay between Fanconi anemia and homologous recombination pathways in genome integrity.
  Journal
EMBO J 35:909-23 (2016)
DOI:10.15252/embj.201693860
Reference
PMID:32466131
  Authors
Renaudin X, Rosselli F
  Title
The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-Links.
  Journal
Genes (Basel) 11:E585 (2020)
DOI:10.3390/genes11050585
Reference
PMID:27145721
  Authors
Ceccaldi R, Sarangi P, D'Andrea AD
  Title
The Fanconi anaemia pathway: new players and new functions.
  Journal
Nat Rev Mol Cell Biol 17:337-49 (2016)
DOI:10.1038/nrm.2016.48
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