KEGG   NETWORK: N01721
Entry
N01721                      Network                                
Name
Autophagosome and lysosome fusion, tethering factor
Definition
RAB7 == (EPG5,PLEKHM1,BIRC6,HOPS,TECPR2) == LC3-II
  Expanded
7879,338382 == (57724,9842,57448,(55823+64601+57617+65082+23339+27072),9895) == ((84557,81631,643246,440738)+C00350)
Class
nt06532 Autophagy
Type
Reference
Pathway
hsa04140  Autophagy - animal
Gene
7879  RAB7A; RAB7A, member RAS oncogene family
338382  RAB7B; RAB7B, member RAS oncogene family
57724  EPG5; ectopic P-granules 5 autophagy tethering factor
9842  PLEKHM1; pleckstrin homology and RUN domain containing M1
57448  BIRC6; baculoviral IAP repeat containing 6
55823  VPS11; VPS11 core subunit of CORVET and HOPS complexes
64601  VPS16; VPS16 core subunit of CORVET and HOPS complexes
57617  VPS18; VPS18 core subunit of CORVET and HOPS complexes
65082  VPS33A; VPS33A core subunit of CORVET and HOPS complexes
23339  VPS39; VPS39 subunit of HOPS complex
27072  VPS41; VPS41 subunit of HOPS complex
9895  TECPR2; tectonin beta-propeller repeat containing 2
84557  MAP1LC3A; microtubule associated protein 1 light chain 3 alpha
81631  MAP1LC3B; microtubule associated protein 1 light chain 3 beta
643246  MAP1LC3B2; microtubule associated protein 1 light chain 3 beta 2
440738  MAP1LC3C; microtubule associated protein 1 light chain 3 gamma
Metabolite
C00350  Phosphatidylethanolamine
Reference
  Authors
Zhao YG, Zhang H
  Title
Autophagosome maturation: An epic journey from the ER to lysosomes.
  Journal
J Cell Biol 218:757-770 (2019)
DOI:10.1083/jcb.201810099
Reference
  Authors
Yu L, Chen Y, Tooze SA
  Title
Autophagy pathway: Cellular and molecular mechanisms.
  Journal
Autophagy 14:207-215 (2018)
DOI:10.1080/15548627.2017.1378838
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