KEGG   NETWORK: N02021
Entry
N02021                      Network                                
Name
Autophagosome-lysosome fusion
Definition
RAB7A+CLN3 == PLKHM1 == HOPS == LC3
  Expanded
7879+1201 == 9842 == (23339+27072+55823+57617+64601+65082) == (84557,81631,643246,440738)
Class
nt06550 Lysosome biogenesis
Type
Reference
Pathway
hsa04142  Lysosome biogenesis
Gene
7879  RAB7A; ras-related protein Rab-7a
1201  CLN3; battenin isoform a
9842  PLEKHM1; pleckstrin homology domain-containing family M member 1 isoform 1
23339  VPS39; vam6/Vps39-like protein isoform a
27072  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform 1
55823  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform 1
57617  VPS18; vacuolar protein sorting-associated protein 18 homolog
64601  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform 1
65082  VPS33A; vacuolar protein sorting-associated protein 33A isoform 1
84557  MAP1LC3A; microtubule-associated protein 1 light chain 3 alpha isoform a
81631  MAP1LC3B; microtubule-associated protein 1 light chain 3 beta
643246  MAP1LC3B2; microtubule-associated protein 1 light chain 3 beta 2
440738  MAP1LC3C; microtubule-associated protein 1 light chain 3 gamma
Reference
  Authors
Ito-Silva VI, Smith BJ, Martins-de-Souza D
  Title
The autophagy proteome in the brain.
  Journal
J Neurochem 169:e16204 (2025)
DOI:10.1111/jnc.16204
Reference
  Authors
Yasa S, Modica G, Sauvageau E, Kaleem A, Hermey G, Lefrancois S
  Title
CLN3 regulates endosomal function by modulating Rab7A-effector interactions.
  Journal
J Cell Sci 133:jcs234047 (2020)
DOI:10.1242/jcs.234047
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