KEGG   REACTION: R01778
Entry
R01778                      Reaction                               
Name
(3S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
Definition
(3S)-3-Hydroxyacyl-CoA + NAD+ <=> 3-Oxoacyl-CoA + NADH + H+
Equation
C00640 + C00003 <=> C00264 + C00004 + C00080
Comment
general reaction
the enzyme ec 1.1.1.35 has broad specificity to acyl chain-length, while ec 1.1.1.211 is long-chain specific
Reaction class
RC00001  C00003_C00004
RC00103  C00264_C00640
Enzyme
1.1.1.35        1.1.1.211
Pathway
rn00062  Fatty acid elongation
Module
M00085  Fatty acid elongation in mitochondria
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35
     R01778  (3S)-3-Hydroxyacyl-CoA + NAD+ <=> 3-Oxoacyl-CoA + NADH + H+
    1.1.1.211
     R01778  (3S)-3-Hydroxyacyl-CoA + NAD+ <=> 3-Oxoacyl-CoA + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.35
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
  1.1.1.211
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
Orthology
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
Other DBs
RHEA: 22435
LinkDB

KEGG   RCLASS: RC00103
Entry
RC00103                     RClass                                 
Definition
C1c-C5a:*-*:C1b+O1a+R-C1b+O5a+R
Reactant pair
C00264_C00640    C00264_C01086    C00685_C01271
C01506_C03667    C20877_C20878
Related class
Reaction
R01778 R01779 R02766 R02767 R03584 R03585 R10826
Enzyme
1.1.1.35        1.1.1.36        1.1.1.100       1.1.1.185       
1.1.1.211       1.1.1.212       1.1.1.330       1.1.1.-
Pathway
rn00061  Fatty acid biosynthesis
rn00062  Fatty acid elongation
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K00023  acetoacetyl-CoA reductase [EC:1.1.1.36]
K00059  3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K10251  17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase [EC:1.1.1.62 1.1.1.330]
K11539  carbonyl reductase 4 / 3-oxoacyl-[acyl-carrier protein] reductase beta subunit [EC:1.1.1.-]

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