KEGG   REACTION: R02235
Entry
R02235                      Reaction                               
Name
dihydrofolate:NAD+ oxidoreductase
Definition
Dihydrofolate + NAD+ <=> Folate + NADH + H+
Equation
C00415 + C00003 <=> C00504 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00158  C00415_C00504
Enzyme
1.5.1.3
Pathway
rn00670  One carbon pool by folate
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3
     R02235  Dihydrofolate + NAD+ <=> Folate + NADH + H+
Orthology
K00287  dihydrofolate reductase [EC:1.5.1.3]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
LinkDB

KEGG   REACTION: R02236
Entry
R02236                      Reaction                               
Name
dihydrofolate:NADP+ oxidoreductase
Definition
Dihydrofolate + NADP+ <=> Folate + NADPH + H+
Equation
C00415 + C00006 <=> C00504 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00158  C00415_C00504
Enzyme
1.5.1.3
Pathway
rn00670  One carbon pool by folate
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3
     R02236  Dihydrofolate + NADP+ <=> Folate + NADPH + H+
Orthology
K00287  dihydrofolate reductase [EC:1.5.1.3]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
Other DBs
RHEA: 31106
LinkDB

KEGG   RCLASS: RC00158
Entry
RC00158                     RClass                                 
Definition
C1x-C8x:*-*:C2y+N1x-C8y+N5x
N1x-N5x:*-*:C1x+C8y-C8x+C8y
Reactant pair
C00415_C00504    C02953_C06313    C04874_C05926
Related class
Reaction
R02235 R02236 R04622 R12644
Enzyme
1.5.1.3         1.5.1.33
Pathway
rn00670  One carbon pool by folate
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Orthology
K00287  dihydrofolate reductase [EC:1.5.1.3]
K03793  pteridine reductase [EC:1.5.1.33]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]

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