KEGG   REACTION: R02542
Entry
R02542                      Reaction                               
Name
sphingomyelin ceramide-phosphohydrolase
Definition
Sphingomyelin + H2O <=> Choline + Ceramide 1-phosphate
Equation
C00550 + C00001 <=> C00114 + C02960
Reaction class
RC00017  C00114_C00550
RC00425  C00550_C02960
Enzyme
3.1.4.41
Pathway
rn00600  Sphingolipid metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.41
     R02542  Sphingomyelin + H2O <=> Choline + Ceramide 1-phosphate
Orthology
K01123  sphingomyelin phosphodiesterase D [EC:3.1.4.41]
Other DBs
RHEA: 20987
LinkDB

KEGG   RCLASS: RC00425
Entry
RC00425                     RClass                                 
Definition
O1c-O2b:*-C1b:P1b-P1b
Reactant pair
C00093_C00344    C00093_C00670    C00093_C01233
C00103_C04645    C00157_C00416    C00157_C00588
C00346_C00350    C00346_C03872    C00346_C04635
C00346_C04756    C00350_C00416    C00550_C00588
C00550_C02960    C00588_C00670    C01177_C01194
C01177_C01225    C01220_C01277    C01245_C04637
C03968_C04476    C04635_C15646    C04756_C15647
Related class
Reaction
R01030 R01310 R01312 R01470 R02027 R02051 R02052 R02541
R02542 R02591 R02817 R03331 R03332 R03435 R04180 R04362
R07380 R07381 R07385 R07388 R10952
Enzyme
3.1.4.2         3.1.4.3         3.1.4.4         3.1.4.11        
3.1.4.12        3.1.4.13        3.1.4.38        3.1.4.39        
3.1.4.41        3.1.4.43        3.1.4.46        3.1.4.51        
3.1.4.62        3.1.4.-         4.6.1.13
Pathway
rn00562  Inositol phosphate metabolism
rn00564  Glycerophospholipid metabolism
rn00565  Ether lipid metabolism
rn00600  Sphingolipid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K01114  phospholipase C [EC:3.1.4.3]
K01115  phospholipase D1/2 [EC:3.1.4.4]
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K01117  sphingomyelin phosphodiesterase [EC:3.1.4.12]
K01122  ectonucleotide pyrophosphatase/phosphodiesterase family member 2 [EC:3.1.4.39]
K01123  sphingomyelin phosphodiesterase D [EC:3.1.4.41]
K01126  glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]
K01771  1-phosphatidylinositol phosphodiesterase [EC:4.6.1.13]
K04714  sphingomyelin synthase / ceramide phosphoethanolamine synthase / phosphatidylethanolamine phospholipase C [EC:2.7.8.27 2.7.8.48 3.1.4.62]
K05857  phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K05860  phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
K05861  phosphatidylinositol phospholipase C, zeta [EC:3.1.4.11]
K08743  ectonucleotide pyrophosphatase/phosphodiesterase family member 6 [EC:3.1.4.-]
K12350  sphingomyelin phosphodiesterase [EC:3.1.4.12]
K12351  sphingomyelin phosphodiesterase 2 [EC:3.1.4.12]
K12352  sphingomyelin phosphodiesterase 3 [EC:3.1.4.12]
K12353  sphingomyelin phosphodiesterase 4 [EC:3.1.4.12]
K12354  ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [EC:3.1.4.12]
K16619  phospholipase C / alpha-toxin [EC:3.1.4.3]
K16860  phospholipase D3/4 [EC:3.1.4.4]
K17717  phospholipase D [EC:3.1.4.4]
K18694  phosphatidylglycerol phospholipase C [EC:3.1.4.-]
K18695  glycerophosphocholine phosphodiesterase GPCPD1 [EC:3.1.4.2]
K18696  glycerophosphodiester phosphodiesterase [EC:3.1.4.46]
K19006  phosphatidylinositol phospholipase C, eta [EC:3.1.4.11]
K22387  lysophospholipase D [EC:3.1.4.39]
K22697  ceramide phosphoethanolamine synthase / phosphatidylethanolamine phospholipase C [EC:2.7.8.48 3.1.4.62]

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