KEGG   REACTION: R03559
Entry
R03559                      Reaction                               
Name
toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
Definition
Toluene + Oxygen + NADH + H+ <=> Toluene-cis-dihydrodiol + NAD+
Equation
C01455 + C00007 + C00004 + C00080 <=> C04592 + C00003
Reaction class
RC00001  C00003_C00004
RC00098  C01455_C04592
Enzyme
1.14.12.11
Pathway
rn00623  Toluene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00547  Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.12  With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
    1.14.12.11
     R03559  Toluene + Oxygen + NADH + H+ <=> Toluene-cis-dihydrodiol + NAD+
Orthology
K03268  benzene/toluene/chlorobenzene dioxygenase subunit alpha [EC:1.14.12.3 1.14.12.11 1.14.12.26]
K16268  benzene/toluene/chlorobenzene dioxygenase subunit beta [EC:1.14.12.3 1.14.12.11 1.14.12.26]
K18089  benzene/toluene/chlorobenzene dioxygenase ferredoxin component
K18090  benzene/toluene/chlorobenzene dioxygenase ferredoxin reductase component [EC:1.18.1.3 1.18.1.-]
Other DBs
RHEA: 16740
LinkDB

KEGG   RCLASS: RC00098
Entry
RC00098                     RClass                                 
Definition
C1y-C8x:O1a-*:C1y+C2x-C8x+C8x
C1y-C8x:O1a-*:C1y+C2y-C8x+C8y
Reactant pair
C00423_C12622    C01455_C04592    C01606_C18314
C05629_C11588    C06584_C06585    C06588_C06589
C06712_C07722    C06727_C07111    C06990_C12837
C07083_C07084    C07715_C07721
Related class
Reaction
R03559 R05261 R05262 R05263 R05264 R05417 R05423 R05435
R05436 R05440 R06782 R06783 R06856 R09227
Enzyme
1.14.12.11      1.14.12.12      1.14.12.18      1.14.12.19      
1.14.12.26      1.14.12.-
Pathway
rn00360  Phenylalanine metabolism
rn00361  Chlorocyclohexane and chlorobenzene degradation
rn00621  Dioxin degradation
rn00623  Toluene degradation
rn00624  Polycyclic aromatic hydrocarbon degradation
rn00642  Ethylbenzene degradation
rn00643  Styrene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
RModule
RM004  Dihydroxylation of aromatic ring, type 1 (dioxygenase and dehydrogenase reactions)
RM010  Dihydroxylation and meta-cleavage of aromatic ring, type 1
Orthology
K00529  3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component [EC:1.18.1.3]
K03268  benzene/toluene/chlorobenzene dioxygenase subunit alpha [EC:1.14.12.3 1.14.12.11 1.14.12.26]
K05708  3-phenylpropionate/trans-cinnamate dioxygenase subunit alpha [EC:1.14.12.19]
K05709  3-phenylpropionate/trans-cinnamate dioxygenase subunit beta [EC:1.14.12.19]
K05710  3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin component
K08689  biphenyl 2,3-dioxygenase subunit alpha [EC:1.14.12.18]
K14578  naphthalene 1,2-dioxygenase ferredoxin component
K14579  naphthalene 1,2-dioxygenase subunit alpha [EC:1.14.12.12 1.14.12.23 1.14.12.24]
K14580  naphthalene 1,2-dioxygenase subunit beta [EC:1.14.12.12 1.14.12.23 1.14.12.24]
K14581  naphthalene 1,2-dioxygenase ferredoxin reductase component [EC:1.18.1.7]
K14748  ethylbenzene dioxygenase subunit alpha [EC:1.14.12.-]
K14749  ethylbenzene dioxygenase subunit beta [EC:1.14.12.-]
K14750  ethylbenzene dioxygenase ferredoxin component
K15750  biphenyl 2,3-dioxygenase subunit beta [EC:1.14.12.18]
K16268  benzene/toluene/chlorobenzene dioxygenase subunit beta [EC:1.14.12.3 1.14.12.11 1.14.12.26]
K18087  biphenyl 2,3-dioxygenase ferredoxin component
K18088  biphenyl 2,3-dioxygenase ferredoxin reductase component [EC:1.18.1.3]
K18089  benzene/toluene/chlorobenzene dioxygenase ferredoxin component
K18090  benzene/toluene/chlorobenzene dioxygenase ferredoxin reductase component [EC:1.18.1.3 1.18.1.-]
K18251  phthalate 3,4-dioxygenase subunit alpha [EC:1.14.12.-]
K18252  phthalate 3,4-dioxygenase subunit beta [EC:1.14.12.-]
K18253  phthalate 3,4-dioxygenase ferredoxin component
K18254  phthalate 3,4-dioxygenase ferredoxin reductase component [EC:1.18.1.3]

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