KEGG   REACTION: R04751
Entry
R04751                      Reaction                               
Name
hexanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Definition
Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2
Equation
C05270 + C00016 <=> C05271 + C01352
Reaction class
RC00052  C05270_C05271
RC00126  C00016_C01352
Enzyme
1.3.3.6         1.3.8.1         1.3.8.5         1.3.8.7         
1.3.8.8         1.3.99.-
Pathway
rn00071  Fatty acid degradation
rn01100  Metabolic pathways
rn01212  Fatty acid metabolism
Module
M00087  beta-Oxidation
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.3  With oxygen as acceptor
    1.3.3.6
     R04751  Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2
   1.3.8  With a flavin as acceptor
    1.3.8.1
     R04751  Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2
    1.3.8.5
     R04751  Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2
    1.3.8.7
     R04751  Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2
    1.3.8.8
     R04751  Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2
   1.3.99  With unknown physiological acceptors
    1.3.99.-
     R04751  Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.3.8.1
   R01178  Short-chain acyl-CoA <=> Electron-transferring flavoprotein
    R04751  Hexanoyl-CoA <=> FAD
  1.3.8.7
   R00392  Acyl-CoA <=> Electron-transferring flavoprotein
    R04751  Hexanoyl-CoA <=> FAD
  1.3.8.8
   R00392  Acyl-CoA <=> Electron-transferring flavoprotein
    R04751  Hexanoyl-CoA <=> FAD
Orthology
K00232  acyl-CoA oxidase [EC:1.3.3.6]
K00248  butyryl-CoA dehydrogenase [EC:1.3.8.1]
K00249  acyl-CoA dehydrogenase [EC:1.3.8.7]
K00255  long-chain-acyl-CoA dehydrogenase [EC:1.3.8.8]
K06445  acyl-CoA dehydrogenase [EC:1.3.99.-]
K09478  short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5]
Reference
1  [PMID:12057976]
  Authors
Campbell JW, Cronan JE Jr.
  Title
The enigmatic Escherichia coli fadE gene is yafH.
  Journal
J Bacteriol 184:3759-64 (2002)
DOI:10.1128/JB.184.13.3759-3764.2002
Other DBs
RHEA: 31210
LinkDB

KEGG   RCLASS: RC00052
Entry
RC00052                     RClass                                 
Definition
C1b-C2b:*-*:C1b+C1b-C1b+C2b
C1b-C2b:*-*:C1b+C5a-C2b+C5a
Reactant pair
C00154_C05272    C00412_C16218    C00527_C02411
C01063_C06723    C01832_C03221    C01944_C05276
C02593_C05273    C02934_C06121    C04088_C16221
C05223_C05758    C05270_C05271    C05274_C05275
C05748_C05749    C05751_C05752    C05754_C05755
C05760_C05761    C05763_C05764    C14143_C14144
C16168_C16374    C16172_C16387    C16327_C16328
C16331_C16332    C16335_C16336    C19846_C20378
C20374_C20375    C20748_C20749
Related class
Reaction
R01278 R01279 R01282 R03776 R03777 R03856 R03857 R03989
R03990 R04092 R04724 R04725 R04751 R04753 R04754 R04955
R04956 R04958 R04959 R04961 R04962 R04966 R04967 R04969
R04970 R05311 R05579 R06943 R06985 R07761 R07765 R07888
R07892 R07896 R07934 R07950 R10074 R10118 R10122 R11600
Enzyme
1.3.1.8         1.3.1.9         1.3.1.10        1.3.1.38        
1.3.1.39        1.3.1.62        1.3.1.93        1.3.1.104       
1.3.1.-         1.3.3.6         1.3.8.1         1.3.8.5         
1.3.8.6         1.3.8.7         1.3.8.8         1.3.8.9         
1.3.8.13        1.3.99.32       1.3.99.-        2.3.1.85        
2.3.1.86        2.3.1.-
Pathway
rn00061  Fatty acid biosynthesis
rn00062  Fatty acid elongation
rn00071  Fatty acid degradation
rn00362  Benzoate degradation
rn00592  alpha-Linolenic acid metabolism
rn00780  Biotin metabolism
rn00930  Caprolactam degradation
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01212  Fatty acid metabolism
rn01240  Biosynthesis of cofactors
RModule
RM018  Beta oxidation in acyl-CoA degradation
RM020  Fatty acid synthesis using acetyl-CoA (reversal of RM018)
RM021  Fatty acid synthesis using malonyl-CoA
Orthology
K00208  enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10]
K00209  enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase (NAD+) [EC:1.3.1.9 1.3.1.44]
K00232  acyl-CoA oxidase [EC:1.3.3.6]
K00248  butyryl-CoA dehydrogenase [EC:1.3.8.1]
K00249  acyl-CoA dehydrogenase [EC:1.3.8.7]
K00252  glutaryl-CoA dehydrogenase [EC:1.3.8.6]
K00255  long-chain-acyl-CoA dehydrogenase [EC:1.3.8.8]
K00665  fatty acid synthase, animal type [EC:2.3.1.85]
K00668  fatty acid synthase subunit beta, fungi type [EC:2.3.1.86]
K02371  enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]
K04118  pimeloyl-CoA dehydrogenase [EC:1.3.1.62]
K06445  acyl-CoA dehydrogenase [EC:1.3.99.-]
K06446  acyl-CoA dehydrogenase [EC:1.3.99.-]
K07512  mitochondrial enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase [EC:1.3.1.- 1.3.1.38]
K09478  short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5]
K09479  very long chain acyl-CoA dehydrogenase [EC:1.3.8.9]
K10258  very-long-chain enoyl-CoA reductase [EC:1.3.1.93]
K10780  enoyl-[acyl-carrier protein] reductase III [EC:1.3.1.104]
K11533  fatty acid synthase, bacteria type [EC:2.3.1.-]
K16173  glutaryl-CoA dehydrogenase (non-decarboxylating) [EC:1.3.99.32]

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