KEGG   PATHWAY: amg00010
Entry
amg00010                    Pathway                                
Name
Glycolysis / Gluconeogenesis - Alteromonas macleodii English Channel 673
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
amg00010  Glycolysis / Gluconeogenesis
amg00010

Module
amg_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:amg00010]
amg_M00002  Glycolysis, core module involving three-carbon compounds [PATH:amg00010]
amg_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:amg00010]
amg_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:amg00010]
Other DBs
GO: 0006096 0006094
Organism
Alteromonas macleodii English Channel 673 [GN:amg]
Gene
AMEC673_11530  glucokinase [KO:K00845] [EC:2.7.1.2]
AMEC673_14790  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
AMEC673_09645  6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
AMEC673_00845  fructose-1,6-bisphosphatase [KO:K03841] [EC:3.1.3.11]
AMEC673_03830  fructose-1,6-bisphosphate aldolase [KO:K01623] [EC:4.1.2.13]
AMEC673_08770  triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
AMEC673_11480  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
AMEC673_11515  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
AMEC673_03825  pgk; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
AMEC673_01435  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
AMEC673_04310  eno; enolase [KO:K01689] [EC:4.2.1.11]
AMEC673_11555  pyruvate kinase II [KO:K00873] [EC:2.7.1.40]
AMEC673_08505  phosphoenolpyruvate synthase [KO:K01007] [EC:2.7.9.2]
AMEC673_14350  aceE; pyruvate dehydrogenase subunit E1 [KO:K00163] [EC:1.2.4.1]
AMEC673_14345  pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase [KO:K00627] [EC:2.3.1.12]
AMEC673_14340  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AMEC673_14830  S-(hydroxymethyl)glutathione dehydrogenase [KO:K00121] [EC:1.1.1.284 1.1.1.1]
AMEC673_06910  zinc-containing alcohol dehydrogenase family protein [KO:K12957] [EC:1.1.1.2 1.1.1.183]
AMEC673_15760  methanol/ethanol family PQQ-dependent dehydrogenase [KO:K00114] [EC:1.1.2.8]
AMEC673_05455  Quinoprotein ethanol dehydrogenase precursor (QEDH) [KO:K00114] [EC:1.1.2.8]
AMEC673_02200  NAD-dependent aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
AMEC673_15860  aldehyde dehydrogenase family protein [KO:K00138] [EC:1.2.1.-]
AMEC673_16675  acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
AMEC673_00935  aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
AMEC673_07030  phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
AMEC673_11520  aldose 1-epimerase [KO:K01792] [EC:5.1.3.15]
AMEC673_18915  phosphoenolpyruvate carboxykinase [KO:K01610] [EC:4.1.1.49]
AMEC673_07085  hypothetical protein [KO:K02777] [EC:2.7.1.-]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
amg00020  Citrate cycle (TCA cycle)
amg00030  Pentose phosphate pathway
amg00500  Starch and sucrose metabolism
amg00620  Pyruvate metabolism
amg00640  Propanoate metabolism
amg00710  Carbon fixation by Calvin cycle
KO pathway
ko00010   
LinkDB

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