KEGG   PATHWAY: aof00020
Entry
aof00020                    Pathway                                
Name
Citrate cycle (TCA cycle) - Asparagus officinalis (garden asparagus)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
aof00020  Citrate cycle (TCA cycle)
aof00020

Module
aof_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:aof00020]
aof_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:aof00020]
aof_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:aof00020]
aof_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:aof00020]
aof_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:aof00020]
Other DBs
GO: 0006099
Organism
Asparagus officinalis (garden asparagus) [GN:aof]
Gene
109827078  citrate synthase, glyoxysomal-like [KO:K01647] [EC:2.3.3.1]
109829885  citrate synthase 4, mitochondrial [KO:K01647] [EC:2.3.3.1]
109820210  citrate synthase 4, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
109842697  LOW QUALITY PROTEIN: ATP-citrate synthase beta chain protein 1 [KO:K01648] [EC:2.3.3.8]
109822637  LOW QUALITY PROTEIN: ATP-citrate synthase alpha chain protein 2 [KO:K01648] [EC:2.3.3.8]
109836296  ATP-citrate synthase alpha chain protein 1 [KO:K01648] [EC:2.3.3.8]
109848914  LOW QUALITY PROTEIN: ATP-citrate synthase alpha chain protein 2-like [KO:K01648] [EC:2.3.3.8]
109848175  ATP-citrate synthase beta chain protein 1 [KO:K01648] [EC:2.3.3.8]
109850513  aconitate hydratase, cytoplasmic isoform X1 [KO:K01681] [EC:4.2.1.3]
109837744  aconitate hydratase, cytoplasmic-like [KO:K01681] [EC:4.2.1.3]
109840741  cytosolic isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
109828859  cytosolic isocitrate dehydrogenase [NADP]-like isoform X1 [KO:K00031] [EC:1.1.1.42]
109847469  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
109837351  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
109823973  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030] [EC:1.1.1.41]
109824330  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
109831304  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial [KO:K00030] [EC:1.1.1.41]
109830306  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
109830182  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
109843241  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
109830642  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
109825699  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
109837346  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
109831458  LOW QUALITY PROTEIN: dihydrolipoyl dehydrogenase 1, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
109848592  dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
109822343  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
109840323  LOW QUALITY PROTEIN: succinate--CoA ligase [ADP-forming] subunit alpha-1, mitochondrial-like [KO:K01899] [EC:6.2.1.4 6.2.1.5]
109850314  succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial [KO:K01899] [EC:6.2.1.4 6.2.1.5]
109836367  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial [KO:K01900] [EC:6.2.1.4 6.2.1.5]
109834329  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
109847779  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
109824390  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
109833748  succinate dehydrogenase subunit 3-1, mitochondrial-like [KO:K00236]
109848841  succinate dehydrogenase subunit 3-2, mitochondrial-like isoform X1 [KO:K00236]
109847282  succinate dehydrogenase subunit 4, mitochondrial-like [KO:K25801]
109846592  fumarate hydratase 1, mitochondrial [KO:K01679] [EC:4.2.1.2]
109827575  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
109839501  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
109851592  LOW QUALITY PROTEIN: malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
109832557  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
109833145  LOW QUALITY PROTEIN: malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
109834303  LOW QUALITY PROTEIN: malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
109840036  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
109843951  LOW QUALITY PROTEIN: malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
109847773  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
109819463  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
109836269  phosphoenolpyruvate carboxykinase (ATP) [KO:K01610] [EC:4.1.1.49]
109831496  pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [KO:K00161] [EC:1.2.4.1]
109823401  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
109837109  LOW QUALITY PROTEIN: pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic [KO:K00161] [EC:1.2.4.1]
109830643  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial [KO:K00162] [EC:1.2.4.1]
109824238  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial-like [KO:K00162] [EC:1.2.4.1]
109825667  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial-like [KO:K00162] [EC:1.2.4.1]
109851472  pyruvate dehydrogenase E1 component subunit beta-like [KO:K00162] [EC:1.2.4.1]
109825621  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like isoform X1 [KO:K00627] [EC:2.3.1.12]
109823942  dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
109851353  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
109851354  dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
109837612  dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
109822233  dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
aof00010  Glycolysis / Gluconeogenesis
aof00053  Ascorbate and aldarate metabolism
aof00061  Fatty acid biosynthesis
aof00062  Fatty acid elongation
aof00071  Fatty acid degradation
aof00190  Oxidative phosphorylation
aof00220  Arginine biosynthesis
aof00250  Alanine, aspartate and glutamate metabolism
aof00280  Valine, leucine and isoleucine degradation
aof00350  Tyrosine metabolism
aof00470  D-Amino acid metabolism
aof00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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