KEGG   PATHWAY: bacu03013
Entry
bacu03013                   Pathway                                
Name
Nucleocytoplasmic transport - Balaenoptera acutorostrata scammoni (minke whale)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
bacu03013  Nucleocytoplasmic transport
bacu03013

Other DBs
GO: 0050658
Organism
Balaenoptera acutorostrata scammoni (minke whale) [GN:bacu]
Gene
102997145  NXF3; nuclear RNA export factor 3 [KO:K14284]
102997844  KPNA5; karyopherin subunit alpha 5 [KO:K15042]
102997907  TPR; translocated promoter region, nuclear basket protein [KO:K09291]
102998069  POM121L2; POM121 transmembrane nucleoporin like 2 [KO:K14316]
102998145  UPF3A; UPF3 regulator of nonsense transcripts homolog A (yeast) [KO:K14328]
102998168  [KO:K14291]
102998239  SNUPN; snurportin 1 [KO:K13151]
102998445  NUP133; nucleoporin 133 [KO:K14300]
102998580  NXT1; nuclear transport factor 2 like export factor 1 [KO:K14285]
102998734  RANBP2; RAN binding protein 2 [KO:K12172] [EC:2.3.2.-]
102999029  [KO:K14306]
102999081  TNPO3; transportin 3 [KO:K15436]
102999086  CASC3; cancer susceptibility candidate 3 [KO:K14323]
102999128  RANGAP1; Ran GTPase activating protein 1 [KO:K14319]
102999152  IPO8; importin 8 [KO:K18755]
102999726  IPO4; importin 4 [KO:K20221]
103000082  UPF3B; UPF3 regulator of nonsense transcripts homolog B (yeast) [KO:K14328]
103000470  NUP62; nucleoporin 62 [KO:K14306]
103000944  NUP54; nucleoporin 54 [KO:K14308]
103001139  KPNA7; karyopherin subunit alpha 7 [KO:K15043]
103001168  [KO:K14285]
103001345  [KO:K12160]
103001812  KPNA1; karyopherin subunit alpha 1 [KO:K23940]
103001981  TNPO2; transportin 2 [KO:K18727]
103002318  IPO13; importin 13 [KO:K25202]
103002830  NUP205; nucleoporin 205 [KO:K14310]
103003007  NUP210L; nucleoporin 210 like [KO:K14314]
103003387  [KO:K12879]
103003388  IPO5; importin 5 [KO:K20222]
103003424  KPNA2; karyopherin subunit alpha 2 [KO:K15043]
103003519  AHCTF1; AT-hook containing transcription factor 1 [KO:K25129]
103003558  [KO:K13176]
103003571  UPF1; UPF1, RNA helicase and ATPase [KO:K14326] [EC:5.6.2.5 5.6.2.3]
103003809  [KO:K12160]
103003832  NUP155; nucleoporin 155 [KO:K14312]
103004390  [KO:K12160]
103004516  THOC6; THO complex 6 [KO:K13175]
103004761  THOC1; THO complex 1 [KO:K12878]
103005493  NUP35; nucleoporin 35 [KO:K14313]
103005621  NUP214; nucleoporin 214 [KO:K14317]
103005938  NDC1; NDC1 transmembrane nucleoporin [KO:K14315]
103006061  NCBP2; nuclear cap binding protein subunit 2 [KO:K12883]
103006077  XPO5; exportin 5 [KO:K14289]
103006115  RBM8A; RNA binding motif protein 8A [KO:K12876]
103006219  SAP18; Sin3A associated protein 18 [KO:K14324]
103006313  POM121C; POM121 transmembrane nucleoporin C [KO:K14316]
103006384  TMEM33; transmembrane protein 33 [KO:K20724]
103006411  CSE1L; chromosome segregation 1 like [KO:K18423]
103006465  [KO:K18655] [EC:5.6.2.7]
103006475  MAGOHB; mago homolog B, exon junction complex core component [KO:K12877]
103006501  MAGOH; mago homolog, exon junction complex core component [KO:K12877]
103006519  KPNA4; karyopherin subunit alpha 4 [KO:K23583]
103006701  EEF1A2; eukaryotic translation elongation factor 1 alpha 2 [KO:K03231]
103006806  NUP85; nucleoporin 85 [KO:K14304]
103006845  IPO7; importin 7 [KO:K20223]
103006894  XPO4; exportin 4 [KO:K25203]
103007450  DDX39B; DExD-box helicase 39B [KO:K12812] [EC:5.6.2.7]
103008173  ACIN1; apoptotic chromatin condensation inducer 1 [KO:K12875]
103008403  SEC13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
103008671  EEF1A1; eukaryotic translation elongation factor 1 alpha 1 [KO:K03231]
103008696  SUMO3; small ubiquitin-like modifier 3 [KO:K12160]
103008958  NMD3; NMD3 ribosome export adaptor [KO:K07562]
103008981  THOC5; THO complex 5 [KO:K13174]
103009015  NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285]
103009085  SUMO1; small ubiquitin-like modifier 1 [KO:K12160]
103009422  AAAS; aladin WD repeat nucleoporin [KO:K14320]
103009685  NUP188; nucleoporin 188 [KO:K14311]
103009725  RAE1; ribonucleic acid export 1 [KO:K14298]
103009735  [KO:K14284]
103010034  NUPL2; nucleoporin like 2 [KO:K14321]
103010257  THOC7; THO complex 7 [KO:K13176]
103010525  NUP93; nucleoporin 93 [KO:K14309]
103010797  NUP58; nucleoporin 58 [KO:K14307]
103011296  THOC3; THO complex 3 [KO:K12880]
103011347  PYM1; PYM homolog 1, exon junction complex associated factor [KO:K14294]
103011488  XPO1; exportin 1 [KO:K14290]
103011534  [KO:K13171]
103011909  KPNA3; karyopherin subunit alpha 3 [KO:K23583]
103012690  XPOT; exportin for tRNA [KO:K14288]
103012781  KPNB1; karyopherin subunit beta 1 [KO:K14293]
103013255  NUP153; nucleoporin 153 [KO:K14296]
103014199  UBE2I; ubiquitin conjugating enzyme E2 I [KO:K10577]
103014283  RNPS1; RNA binding protein with serine rich domain 1 [KO:K14325]
103014735  SEH1L; SEH1 like nucleoporin [KO:K14299]
103014765  IPO9; importin 9 [KO:K20224]
103014852  [KO:K12160]
103015513  [KO:K12160]
103015762  PNN; pinin, desmosome associated protein [KO:K13114]
103015988  NUP88; nucleoporin 88 [KO:K14318]
103016357  NUP37; nucleoporin 37 [KO:K14302]
103016433  NUP210; nucleoporin 210 [KO:K14314]
103016542  UPF2; UPF2 regulator of nonsense transcripts homolog (yeast) [KO:K14327]
103016708  [KO:K12160]
103016756  [KO:K14325]
103016841  RAN; RAN, member RAS oncogene family [KO:K07936]
103016861  [KO:K12160]
103016872  GLE1; GLE1, RNA export mediator [KO:K18723]
103017149  NUP98; nucleoporin 98 [KO:K14297]
103017272  NUP160; nucleoporin 160 [KO:K14303]
103017593  [KO:K03231]
103017634  NCBP1; nuclear cap binding protein subunit 1 [KO:K12882]
103017765  PHAX; phosphorylated adaptor for RNA export [KO:K14291]
103018146  ALYREF; Aly/REF export factor [KO:K12881]
103018271  [KO:K14306]
103018529  KPNA6; karyopherin subunit alpha 6 [KO:K15042]
103018739  NUP107; nucleoporin 107 [KO:K14301]
103018835  TNPO1; transportin 1 [KO:K18752]
103019164  XPO7; exportin 7 [KO:K18460]
103019204  SENP2; SUMO1/sentrin/SMT3 specific peptidase 2 [KO:K03345] [EC:3.4.22.68]
103019689  XPO6; exportin 6 [KO:K25204]
103019837  NUP43; nucleoporin 43 [KO:K14305]
103019889  NUP50; nucleoporin 50 [KO:K14295]
103020120  DDX19B; DEAD-box helicase 19B [KO:K18655] [EC:5.6.2.7]
103020432  EIF4A3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:5.6.2.7]
103020689  DDX19A; DEAD-box helicase 19A [KO:K18655] [EC:5.6.2.7]
103020946  NXF1; nuclear RNA export factor 1 [KO:K14284]
103020955  IPO11; importin 11 [KO:K25201]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
bacu03015  mRNA surveillance pathway
KO pathway
ko03013   

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