KEGG   PATHWAY: bcoc00260
Entry
bcoc00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Blautia producta DSM 935
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bcoc00260  Glycine, serine and threonine metabolism
bcoc00260

Module
bcoc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bcoc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Blautia producta DSM 935 [GN:bcoc]
Gene
BLCOC_01390  hpr_1; Hydroxypyruvate reductase [KO:K00018] [EC:1.1.1.29]
BLCOC_08080  glyA_1; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BLCOC_14230  garK; Glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
BLCOC_14360  glyA_2; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BLCOC_16940  tdh_5; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BLCOC_17010  mtgB_1; Glycine betaine methyltransferase [KO:K25220]
BLCOC_18930  lysC; Aspartokinase [KO:K00928] [EC:2.7.2.4]
BLCOC_19190  serB_2; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
BLCOC_19690  hpr_2; Hydroxypyruvate reductase [KO:K00018] [EC:1.1.1.29]
BLCOC_22790  mtgB_2; Glycine betaine methyltransferase [KO:K25220]
BLCOC_22880  mtgB_3; Glycine betaine methyltransferase [KO:K25220]
BLCOC_23180  hom_1; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BLCOC_23760  trpB_1; Tryptophan synthase beta chain [KO:K06001] [EC:4.2.1.20]
BLCOC_26440  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
BLCOC_29750  ygeA_1; L-aspartate/glutamate-specific racemase [KO:K25316]
BLCOC_32100  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
BLCOC_32110  trpB_2; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
BLCOC_33840  tdcB; L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
BLCOC_34130  yclM; Aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
BLCOC_35670  asd2; Aspartate-semialdehyde dehydrogenase 2 [KO:K00133] [EC:1.2.1.11]
BLCOC_35800  trpB_3; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
BLCOC_36150  pdxB; Erythronate-4-phosphate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BLCOC_36160  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BLCOC_36270  sdhA; L-serine dehydratase, alpha chain [KO:K01752] [EC:4.3.1.17]
BLCOC_36280  sdhB; L-serine dehydratase, beta chain [KO:K01752] [EC:4.3.1.17]
BLCOC_36580  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
BLCOC_38970  [KO:K17103] [EC:2.7.8.8]
BLCOC_43120  mtgB_5; Glycine betaine methyltransferase [KO:K25220]
BLCOC_43160  mtgB_6; Glycine betaine methyltransferase [KO:K25220]
BLCOC_47620  apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15635] [EC:5.4.2.12]
BLCOC_47630  hom_2; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BLCOC_51890  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BLCOC_53830  [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BLCOC_54130  tdh_8; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bcoc00010  Glycolysis / Gluconeogenesis
bcoc00020  Citrate cycle (TCA cycle)
bcoc00230  Purine metabolism
bcoc00250  Alanine, aspartate and glutamate metabolism
bcoc00270  Cysteine and methionine metabolism
bcoc00290  Valine, leucine and isoleucine biosynthesis
bcoc00300  Lysine biosynthesis
bcoc00330  Arginine and proline metabolism
bcoc00460  Cyanoamino acid metabolism
bcoc00470  D-Amino acid metabolism
bcoc00564  Glycerophospholipid metabolism
bcoc00600  Sphingolipid metabolism
bcoc00620  Pyruvate metabolism
bcoc00630  Glyoxylate and dicarboxylate metabolism
bcoc00640  Propanoate metabolism
bcoc00680  Methane metabolism
bcoc00860  Porphyrin metabolism
bcoc00920  Sulfur metabolism
KO pathway
ko00260   

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