KEGG PATHWAY: blen00260

PATHWAY: blen00260

Entry

blen00260                   Pathway

Name

Glycine, serine and threonine metabolism - Lederbergia lenta

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

blen00260

Glycine, serine and threonine metabolism

Module

blen_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:blen00260]

blen_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:blen00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Lederbergia lenta [GN:blen]

Gene

NCTC4824_00046

mccB; cystathionine gamma-lyase [KO:K17217] [EC:4.4.1.1 4.4.1.2]

NCTC4824_00526

ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]

NCTC4824_00639

bsmA_1; SAM dependent methyltransferase [KO:K18896] [EC:2.1.1.156]

NCTC4824_00686

glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]

NCTC4824_00716

trpB_1; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]

NCTC4824_00717

trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]

NCTC4824_00839

soxA_1; sarcosine oxidase, monomeric form [KO:K00301] [EC:1.5.3.1]

NCTC4824_01092

yvcT; 2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

NCTC4824_01198

serA_1; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

NCTC4824_01206

thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]

NCTC4824_01207

thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]

NCTC4824_01208

hom_1; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

NCTC4824_01447

lysC; 408) and subunit beta (aa 246->408)408)408) [KO:K00928] [EC:2.7.2.4]

NCTC4824_01620

pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]

NCTC4824_01776

bfmBC; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]

NCTC4824_02077

yjjG_1; HAD-superfamily hydrolase [KO:K25528]

NCTC4824_02219

psa; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

NCTC4824_02284

gpm; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]

NCTC4824_02613

dapG; aspartokinase I [KO:K00928] [EC:2.7.2.4]

NCTC4824_02614

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

NCTC4824_02811

pdhD; dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes [KO:K00382] [EC:1.8.1.4]

NCTC4824_03323

soxA_2; sarcosine oxidase, monomeric form [KO:K00301] [EC:1.5.3.1]

NCTC4824_03327

gcvH; glycine cleavage system protein H [KO:K02437]

NCTC4824_03409

gpmI; phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [KO:K15633] [EC:5.4.2.12]

NCTC4824_03454

trpB_2; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]

NCTC4824_03461

hom_2; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

NCTC4824_03880

glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

C23135

(2S,3S)-2-Acetamido-3-hydroxy-4-aminobutyrate

C23136

4-Amino-L-allothreonine

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721