KEGG   PATHWAY: bsu00260
Entry
bsu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus subtilis subsp. subtilis 168
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bsu00260  Glycine, serine and threonine metabolism
bsu00260

Module
bsu_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bsu00260]
bsu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bsu00260]
bsu_M00555  Betaine biosynthesis, choline => betaine [PATH:bsu00260]
bsu_M00621  Glycine cleavage system [PATH:bsu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus subtilis subsp. subtilis 168 [GN:bsu]
Gene
BSU02270  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BSU03790  yclM; aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
BSU08090  acoL; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSU10020  serC; 3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
BSU14610  pdhD; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSU15850  sdaAB; L-serine dehydratase, beta chain [KO:K01752] [EC:4.3.1.17]
BSU15860  sdaAA; L-serine dehydratase, alpha chain [KO:K01752] [EC:4.3.1.17]
BSU16750  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BSU16760  dapG; aspartokinase 1 [KO:K00928] [EC:2.7.2.4]
BSU16990  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BSU17000  kbl; 8-amino-7-oxononanoate synthase [KO:K00639] [EC:2.3.1.29]
BSU18560  yoaD; 2-hydroxyacid dehydrogenase YoaD [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSU21770  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BSU22630  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
BSU22640  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
BSU23070  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSU23770  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
BSU24060  lpdV; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSU24550  gcvPB; glycine dehydrogenase subunit 2 [KO:K00283] [EC:1.4.4.2]
BSU24560  gcvPA; glycine dehydrogenase subunit 1 [KO:K00282] [EC:1.4.4.2]
BSU24570  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
BSU27250  yrhB; cystathionine gamma-lyase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
BSU28470  lysC; aspartokinase 2 [KO:K00928] [EC:2.7.2.4]
BSU28940  ysaA; hydrolase YsaA [KO:K25528]
BSU31050  gbsB; alcohol dehydrogenase [KO:K11440] [EC:1.1.1.1]
BSU31060  gbsA; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BSU32240  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
BSU32250  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BSU32260  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BSU32800  yusH; glycine cleavage system H protein [KO:K02437]
BSU33910  pgm; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
BSU34430  racX; amino acid racemase [KO:K25316]
BSU34680  yvcT; 2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BSU36900  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BSU40040  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bsu00010  Glycolysis / Gluconeogenesis
bsu00020  Citrate cycle (TCA cycle)
bsu00230  Purine metabolism
bsu00250  Alanine, aspartate and glutamate metabolism
bsu00270  Cysteine and methionine metabolism
bsu00290  Valine, leucine and isoleucine biosynthesis
bsu00300  Lysine biosynthesis
bsu00330  Arginine and proline metabolism
bsu00460  Cyanoamino acid metabolism
bsu00470  D-Amino acid metabolism
bsu00564  Glycerophospholipid metabolism
bsu00600  Sphingolipid metabolism
bsu00620  Pyruvate metabolism
bsu00630  Glyoxylate and dicarboxylate metabolism
bsu00640  Propanoate metabolism
bsu00680  Methane metabolism
bsu00860  Porphyrin metabolism
bsu00920  Sulfur metabolism
KO pathway
ko00260   

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