Entry Name Quorum sensing - Bacillus subtilis subsp. subtilis 168
Description Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
Class Cellular Processes; Cellular community - prokaryotesBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Bacillus subtilis subsp. subtilis 168 [GN:
bsu ]
Gene BSU11430 oppA; oligopeptide ABC transporter binding lipoprotein [KO:K15580 ]
BSU11440 oppB; oligopeptide transport system permease protein OppB [KO:K15581 ]
BSU11450 oppC; oligopeptide transport system permease protein OppC [KO:K15582 ]
BSU11460 oppD; oligopeptide transport ATP-binding protein OppD [KO:K15583 ]
BSU11470 oppF; oligopeptide transport ATP-binding protein OppF [KO:K10823 ]
BSU21470 sunT; sublancin-168-processing and transport ATP-binding protein SunT [KO:K20344 ]
BSU11390 appB; oligopeptide transport system permease protein AppB [KO:K02033 ]
BSU11400 appC; oligopeptide transport system permease protein AppC [KO:K02034 ]
BSU11360 appD; oligopeptide transport ATP-binding protein AppD [KO:K02031 ]
BSU11370 appF; oligopeptide transport ATP-binding protein AppF [KO:K02032 ]
BSU13000 ykfD; oligopeptide transport ATP-binding protein YkfD [KO:K02032 ]
BSU03770 rapC; response regulator aspartate phosphatase C [KO:K06361 ] [EC:3.1.-.-]
BSU37460 rapF; response regulator aspartate phosphatase F [KO:K06364 ] [EC:3.1.-.-]
BSU18910 rapK; response regulator aspartate phosphatase K [KO:K06369 ] [EC:3.1.-.-]
BSU40300 rapG; response regulator aspartate phosphatase G [KO:K06365 ] [EC:3.1.-.-]
BSU06830 rapH; response regulator aspartate phosphatase H [KO:K06366 ] [EC:3.1.-.-]
BSU12430 rapA; response regulator aspartate phosphatase A [KO:K06359 ] [EC:3.1.-.-]
BSU25830 rapE; response regulator aspartate phosphatase E [KO:K06363 ] [EC:3.1.-.-]
BSU36690 rapB; response regulator aspartate phosphatase B [KO:K06360 ] [EC:3.1.-.-]
BSU37130 spo0F; sporulation initiation phosphotransferase F [KO:K02490 ]
BSU27930 spo0B; sporulation initiation phosphotransferase B [KO:K06375 ] [EC:2.7.-.-]
Compound C11837 N-Butyryl-L-homoserine lactone
C11841 N-(3-Oxooctanoyl)homoserine lactone
C11844 N-Heptanoylhomoserine lactone
C11845 N-(3-Hydroxy-7-cis-tetradecenoyl)homoserine lactone
C11848 2-Heptyl-3-hydroxy-quinolone
C18049 N-Acyl-L-homoserine lactone
C18206 cis-11-Methyl-2-dodecenoic acid
C20643 2-Heptyl-4(1H)-quinolone
C20677 N-(4-Coumaroyl)-L-homoserine lactone
C20959 (4S)-4-Hydroxy-5-phosphooxypentane-2,3-dione
C21195 N-(3-Hydroxybutanoyl)-L-homoserine lactone
C21197 N-Hexanoyl-L-homoserine lactone
C21198 N-(3-Oxohexanoyl)-L-homoserine lactone
C21199 N-Octanoyl-L-homoserine lactone
C21200 N-3-Hydroxyoctanoyl-L-homoserine lactone
C21201 N-3-Oxo-dodecanoyl-L-homoserine lactone
Reference Authors Pereira CS, Thompson JA, Xavier KB
Title AI-2-mediated signalling in bacteria.
Journal Reference Authors Verma SC, Miyashiro T
Title Quorum sensing in the squid-Vibrio symbiosis.
Journal Reference Authors Norsworthy AN, Visick KL
Title Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
Journal Reference Authors Papaioannou E, Utari PD, Quax WJ
Title Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.
Journal Reference Authors Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Camara M
Title Quinolones: from antibiotics to autoinducers.
Journal Reference Authors Rasamiravaka T, Labtani Q, Duez P, El Jaziri M
Title The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
Journal Reference Authors Whiteley M, Greenberg EP
Title Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes.
Journal Reference Authors Chin-A-Woeng TF, van den Broek D, de Voer G, van der Drift KM, Tuinman S, Thomas-Oates JE, Lugtenberg BJ, Bloemberg GV
Title Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium.
Journal Reference Authors Hughes DT, Clarke MB, Yamamoto K, Rasko DA, Sperandio V
Title The QseC adrenergic signaling cascade in Enterohemorrhagic E. coli (EHEC).
Journal Reference Authors Njoroge J, Sperandio V
Title Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE.
Journal Reference Authors Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V
Title Fucose sensing regulates bacterial intestinal colonization.
Journal Reference Authors Hirakawa H, Harwood CS, Pechter KB, Schaefer AL, Greenberg EP
Title Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression.
Journal Reference Authors Danino VE, Wilkinson A, Edwards A, Downie JA
Title Recipient-induced transfer of the symbiotic plasmid pRL1JI in Rhizobium leguminosarum bv. viciae is regulated by a quorum-sensing relay.
Journal Reference Authors Wisniewski-Dye F, Downie JA
Title Quorum-sensing in Rhizobium.
Journal Reference Authors Rodelas B, Lithgow JK, Wisniewski-Dye F, Hardman A, Wilkinson A, Economou A, Williams P, Downie JA
Title Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae.
Journal Reference Authors Lang J, Faure D
Title Functions and regulation of quorum-sensing in Agrobacterium tumefaciens.
Journal Reference Authors Planamente S, Morera S, Faure D
Title In planta fitness-cost of the Atu4232-regulon encoding for a selective GABA-binding sensor in Agrobacterium.
Journal Reference Authors Barnard AM, Salmond GP
Title Quorum sensing in Erwinia species.
Journal Reference Authors Barnard AM, Bowden SD, Burr T, Coulthurst SJ, Monson RE, Salmond GP
Title Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria.
Journal Reference Authors Carlier A, Burbank L, von Bodman SB
Title Identification and characterization of three novel EsaI/EsaR quorum-sensing controlled stewartan exopolysaccharide biosynthetic genes in Pantoea stewartii ssp. stewartii.
Journal Reference Authors Beck von Bodman S, Farrand SK
Title Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an N-acylhomoserine lactone autoinducer.
Journal Reference Authors O'Grady EP, Viteri DF, Malott RJ, Sokol PA
Title Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.
Journal Reference Authors Malott RJ, Baldwin A, Mahenthiralingam E, Sokol PA
Title Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia.
Journal Reference Authors Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L, Zhang LH
Title Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover.
Journal Reference Authors Suppiger A, Schmid N, Aguilar C, Pessi G, Eberl L
Title Two quorum sensing systems control biofilm formation and virulence in members of the Burkholderia cepacia complex.
Journal Reference Authors Deng Y, Wu J, Tao F, Zhang LH
Title Listening to a new language: DSF-based quorum sensing in Gram-negative bacteria.
Journal Reference Authors Ryan RP, Dow JM
Title Communication with a growing family: diffusible signal factor (DSF) signaling in bacteria.
Journal Reference Authors Kim J, Kim JG, Kang Y, Jang JY, Jog GJ, Lim JY, Kim S, Suga H, Nagamatsu T, Hwang I
Title Quorum sensing and the LysR-type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae.
Journal Reference Authors Kim J, Kang Y, Choi O, Jeong Y, Jeong JE, Lim JY, Kim M, Moon JS, Suga H, Hwang I
Title Regulation of polar flagellum genes is mediated by quorum sensing and FlhDC in Burkholderia glumae.
Journal Reference Authors Stauff DL, Bassler BL
Title Quorum sensing in Chromobacterium violaceum: DNA recognition and gene regulation by the CviR receptor.
Journal Reference Authors Chen G, Swem LR, Swem DL, Stauff DL, O'Loughlin CT, Jeffrey PD, Bassler BL, Hughson FM
Title A strategy for antagonizing quorum sensing.
Journal Reference Authors Hao G, Burr TJ
Title Regulation of long-chain N-acyl-homoserine lactones in Agrobacterium vitis.
Journal Reference Authors Savka MA, Le PT, Burr TJ
Title LasR receptor for detection of long-chain quorum-sensing signals: identification of N-acyl-homoserine lactones encoded by the avsI locus of Agrobacterium vitis.
Journal Reference Authors Le KY, Otto M
Title Quorum-sensing regulation in staphylococci-an overview.
Journal Reference Authors Queck SY, Jameson-Lee M, Villaruz AE, Bach TH, Khan BA, Sturdevant DE, Ricklefs SM, Li M, Otto M
Title RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus.
Journal Reference Authors Darkoh C, DuPont HL, Norris SJ, Kaplan HB
Title Toxin synthesis by Clostridium difficile is regulated through quorum signaling.
Journal Reference Authors Vidal JE, Shak JR, Canizalez-Roman A
Title The CpAL quorum sensing system regulates production of hemolysins CPA and PFO to build Clostridium perfringens biofilms.
Journal Reference Authors Ohtani K, Yuan Y, Hassan S, Wang R, Wang Y, Shimizu T
Title Virulence gene regulation by the agr system in Clostridium perfringens.
Journal Reference Authors Li YH, Tian X
Title Quorum sensing and bacterial social interactions in biofilms.
Journal Reference Authors Berg KH, Biornstad TJ, Johnsborg O, Havarstein LS
Title Properties and biological role of streptococcal fratricins.
Journal Reference Authors Conrads G, de Soet JJ, Song L, Henne K, Sztajer H, Wagner-Dobler I, Zeng AP
Title Comparing the cariogenic species Streptococcus sobrinus and S. mutans on whole genome level.
Journal Reference Authors Jimenez JC, Federle MJ
Title Quorum sensing in group A Streptococcus.
Journal Reference Authors Cook LC, Federle MJ
Title Peptide pheromone signaling in Streptococcus and Enterococcus.
Journal Reference Authors Podbielski A, Leonard BA
Title The group A streptococcal dipeptide permease (Dpp) is involved in the uptake of essential amino acids and affects the expression of cysteine protease.
Journal Reference Authors Podbielski A, Pohl B, Woischnik M, Korner C, Schmidt KH, Rozdzinski E, Leonard BA
Title Molecular characterization of group A streptococcal (GAS) oligopeptide permease (opp) and its effect on cysteine protease production.
Journal Reference Authors Anbalagan S, Dmitriev A, McShan WM, Dunman PM, Chaussee MS
Title Growth phase-dependent modulation of Rgg binding specificity in Streptococcus pyogenes.
Journal Reference Authors Clewell DB
Title Tales of conjugation and sex pheromones: A plasmid and enterococcal odyssey.
Journal Reference Authors Wardal E, Sadowy E, Hryniewicz W
Title Complex nature of enterococcal pheromone-responsive plasmids.
Journal Pol J Microbiol 59:79-87 (2010)
Reference Authors Roux A, Payne SM, Gilmore MS
Title Microbial telesensing: probing the environment for friends, foes, and food.
Journal Reference Authors Slamti L, Perchat S, Huillet E, Lereclus D
Title Quorum sensing in Bacillus thuringiensis is required for completion of a full infectious cycle in the insect.
Journal Reference Authors Lopez D, Kolter R
Title Extracellular signals that define distinct and coexisting cell fates in Bacillus subtilis.
Journal Reference Authors Stephenson S, Mueller C, Jiang M, Perego M
Title Molecular analysis of Phr peptide processing in Bacillus subtilis.
Journal Reference Authors Lanigan-Gerdes S, Dooley AN, Faull KF, Lazazzera BA
Title Identification of subtilisin, Epr and Vpr as enzymes that produce CSF, an extracellular signalling peptide of Bacillus subtilis.
Journal Reference Authors Kleerebezem M
Title Quorum sensing control of lantibiotic production; nisin and subtilin autoregulate their own biosynthesis.
Journal Reference Authors Rutherford ST, Bassler BL
Title Bacterial quorum sensing: its role in virulence and possibilities for its control.
Journal Reference Authors LaSarre B, Federle MJ
Title Exploiting quorum sensing to confuse bacterial pathogens.
Journal Reference Authors Sifri CD
Title Healthcare epidemiology: quorum sensing: bacteria talk sense.
Journal Related KO pathway LinkDB All DBs
