Entry
Name
Linoleic acid metabolism - Bos taurus (cow)
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
Other DBs
Organism
Bos taurus (cow) [GN:
bta ]
Gene
282213 CYP2E1; cytochrome P450 2E1 [KO:K07415 ] [EC:1.14.14.-]
494318 PLA2G2D1; calcium-dependent phospholipase A2 PLA2G2D1 precursor [KO:K01047 ] [EC:3.1.1.4 ]
503625 PLA2G2D4; calcium-dependent phospholipase A2 PLA2G2D4 precursor [KO:K01047 ] [EC:3.1.1.4 ]
504978 PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047 ] [EC:3.1.1.4 ]
535381 PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343 ] [EC:3.1.1.4 ]
Compound
C03242 Dihomo-gamma-linolenate
C04717 (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid
C06426 (6Z,9Z,12Z)-Octadecatrienoic acid
C07338 (9Z,12Z)-(11S)-11-Hydroperoxyoctadeca-9,12-dienoic acid
C14832 12,13-Epoxy-9-hydroxy-10-octadecenoate
C14834 9,10-Epoxy-13-hydroxy-11-octadecenoate
C14836 9,10-12,13-Diepoxyoctadecanoate
C14837 9,10-Dihydroxy-12,13-epoxyoctadecanoate
C19937 (8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoate
C22918 (9Z,11E)-12-[(1E)-Hex-1-en-1-yloxy]dodeca-9,11-dienoic acid
Reference
Authors
Nowak G, Grant DF, Moran JH.
Title
Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia.
Journal
Reference
Authors
Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM.
Title
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
Journal
Reference
Authors
Spiteller G.
Title
Do changes in the cell membrane structure induce the generation of lipid peroxidation products which serve as first signalling molecules in cell to cell communication?
Journal
Reference
Authors
Jude AR, Little JM, Bull AW, Podgorski I, Radominska-Pandya A.
Title
13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases.
Journal
Drug Metab Dispos 29:652-5 (2001)
Reference
Authors
Su C, Sahlin M, Oliw EH.
Title
A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities.
Journal
Reference
Authors
Brodowsky ID, Hamberg M, Oliw EH.
Title
A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid.
Journal
J Biol Chem 267:14738-45 (1992)
Reference
Authors
Hamberg M, Hamberg G.
Title
Peroxygenase-Catalyzed Fatty Acid Epoxidation in Cereal Seeds (Sequential Oxidation of Linoleic Acid into 9(S),12(S),13(S)-Trihydroxy-10(E)-Octadecenoic Acid).
Journal
Reference
Authors
Moghaddam M, Motoba K, Borhan B, Pinot F, Hammock BD.
Title
Novel metabolic pathways for linoleic and arachidonic acid metabolism.
Journal
Related pathway
KO pathway