KEGG   PATHWAY: bta00590
Entry
bta00590                    Pathway                                
Name
Arachidonic acid metabolism - Bos taurus (cow)
Class
Metabolism; Lipid metabolism
Pathway map
bta00590  Arachidonic acid metabolism
bta00590

Other DBs
GO: 0019369
Organism
Bos taurus (cow) [GN:bta]
Gene
282457  PLA2G1B; phospholipase A2 preproprotein [KO:K01047] [EC:3.1.1.4]
503625  PLA2G2D4; calcium-dependent phospholipase A2 PLA2G2D4 precursor [KO:K01047] [EC:3.1.1.4]
494318  PLA2G2D1; calcium-dependent phospholipase A2 PLA2G2D1 precursor [KO:K01047] [EC:3.1.1.4]
613966  group 10 secretory phospholipase A2 isoform X2 [KO:K01047] [EC:3.1.1.4]
527631  PLA2G3; group 3 secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
521383  PLA2G2A; phospholipase A2, membrane associated precursor [KO:K01047] [EC:3.1.1.4]
614911  PLA2G5; phospholipase A2 group V precursor [KO:K01047] [EC:3.1.1.4]
506243  PLA2G2E; group IIE secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
507201  PLA2G2A; phospholipase A2, membrane associated precursor [KO:K01047] [EC:3.1.1.4]
504978  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
541294  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
527214  PLA2G12A; group XIIA secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
615045  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
100337447  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
112443425  group IID secretory phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
526364  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
505485  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
522866  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
531209  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
525072  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
535381  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
506508  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
506802  PLA2G16; group XVI phospholipase A2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100336631  phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
614402  phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
618367  uncharacterized protein LOC618367 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
282022  PTGS1; prostaglandin G/H synthase 1 precursor [KO:K00509] [EC:1.14.99.1]
282023  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
282019  PTGES; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
493639  PTGES2; prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
493638  PTGES3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
515946  CBR1; carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
510180  MGC127133; 20-beta-hydroxysteroid dehydrogenase-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
112441473  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
782391  DCXR; carbonyl reductase [NADPH] 2 [KO:K00081] [EC:1.1.1.184]
516036  CBR3; carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
617001  PRXL2B; prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
512259  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
509326  TBXAS1; thromboxane-A synthase [KO:K01832] [EC:5.3.99.5]
286858  PTGDS; prostaglandin-H2 D-isomerase precursor [KO:K01830] [EC:5.3.99.2]
100139892  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
100139386  20ALPHA-HSD; placental and ovary 20alpha hydroxysteroid dehydrogenase protein [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
617917  AKR1C3; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
282138  AKR1C4; dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
506594  prostaglandin F synthase 1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
527068  aldo-keto reductase family 1 member C3 -like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
538060  aldo-keto reductase family 1, member C1-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
782884  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
112449293  dihydrodiol dehydrogenase 3-like isoform X3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
112441538  dihydrodiol dehydrogenase 3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
282021  PTGIS; prostacyclin synthase precursor [KO:K01831] [EC:5.3.99.4]
404074  ALOX5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
507130  LTA4H; leukotriene A-4 hydrolase [KO:K01254] [EC:3.3.2.6]
532505  PTGR3; prostaglandin reductase-3 [KO:K07119] [EC:1.3.1.48]
506263  PTGR2; prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]
513177  PTGR1; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
511749  LTC4S; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
615582  GGT1; gamma-glutamyltranspeptidase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
787326  GGT5; glutathione hydrolase 5 proenzyme precursor [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
286809  GPX4; phospholipid hydroperoxide glutathione peroxidase isoform A precursor [KO:K05361] [EC:1.11.1.12]
282213  CYP2E1; cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
510406  CYP2J30; cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
107132327  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
521656  cytochrome P450, family 2, subfamily J [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
511936  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
530929  cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
535227  CYP2U1; cytochrome P450 2U1 [KO:K07422] [EC:1.14.14.80]
516085  CYP4A22; cytochrome P450, family 4, subfamily A, polypeptide 22 [KO:K07425] [EC:1.14.14.80]
511890  CYP4A11; cytochrome P450, family 4, subfamily A, polypeptide 11 [KO:K07425] [EC:1.14.14.80]
784417  CYP4A59; cytochrome P450 4A25 isoform X1 [KO:K07425] [EC:1.14.14.80]
407169  ALOX12; polyunsaturated fatty acid lipoxygenase ALOX12 [KO:K00458] [EC:1.13.11.31]
787450  ALOX12E; arachidonate 12-lipoxygenase, epidermal-type [KO:K00458] [EC:1.13.11.31]
517001  ALOXE3; hydroperoxide isomerase ALOXE3 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
504803  ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
286820  ALOX15B; arachidonate 15-lipoxygenase B [KO:K08022] [EC:1.13.11.33 1.13.11.-]
504769  CYP2B6; cytochrome P450 family 2 subfamily B member 6 precursor [KO:K07412] [EC:1.14.14.1]
530571  CYP2B39; cytochrome P450 2B4-like [KO:K07412] [EC:1.14.14.1]
511498  CYP2C23; cytochrome P450 family 2 subfamily C member 23 [KO:K07413] [EC:1.14.14.1]
616593  CYP2C87; cytochrome P450 family 2 subfamily C member 87 precursor [KO:K07413] [EC:1.14.14.1]
785540  CYP2C281; cytochrome P450 2C31 [KO:K07413] [EC:1.14.14.1]
510380  CYP2C89; cytochrome P450 family 2 subfamily C member 89 [KO:K07413] [EC:1.14.14.1]
505468  CYP2C88; cytochrome P450 2C19 [KO:K07413] [EC:1.14.14.1]
535243  CYP2C90; cytochrome P450 family 2 subfamily C member 90 precursor [KO:K07413] [EC:1.14.14.1]
511716  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
282139  ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
bta00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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