KEGG   PATHWAY: bthy00260
Entry
bthy00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus thuringiensis YWC2-8
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bthy00260  Glycine, serine and threonine metabolism
bthy00260

Module
bthy_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bthy00260]
bthy_M00621  Glycine cleavage system [PATH:bthy00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus thuringiensis YWC2-8 [GN:bthy]
Gene
AQ980_21005  aspartate kinase [KO:K00928] [EC:2.7.2.4]
AQ980_10930  aspartate kinase [KO:K00928] [EC:2.7.2.4]
AQ980_17830  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AQ980_10925  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AQ980_02270  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AQ980_20355  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AQ980_14255  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AQ980_20345  homoserine kinase [KO:K00872] [EC:2.7.1.39]
AQ980_20350  threonine synthase [KO:K01733] [EC:4.2.3.1]
AQ980_02745  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AQ980_05275  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AQ980_00875  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AQ980_17565  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
AQ980_11200  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
AQ980_04605  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
AQ980_21325  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
AQ980_19790  phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
AQ980_03950  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
AQ980_17285  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AQ980_17290  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
AQ980_27490  8-amino-7-oxononanoate synthase [KO:K00639] [EC:2.3.1.29]
AQ980_20055  amine oxidase [KO:K00274] [EC:1.4.3.4]
AQ980_20560  amine oxidase [KO:K00274] [EC:1.4.3.4]
AQ980_08685  glycine dehydrogenase [KO:K00282] [EC:1.4.4.2]
AQ980_08690  glycine dehydrogenase [KO:K00283] [EC:1.4.4.2]
AQ980_08680  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
AQ980_09020  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AQ980_10075  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AQ980_15075  acoL; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AQ980_04510  glycine cleavage system protein H [KO:K02437]
AQ980_22725  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
AQ980_25320  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
AQ980_12540  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
AQ980_07960  cystathionine gamma-synthase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
AQ980_09155  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AQ980_09160  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AQ980_13715  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AQ980_13720  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AQ980_17650  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AQ980_20845  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AQ980_21145  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
AQ980_06075  amino acid racemase [KO:K25316] [EC:5.1.1.10]
AQ980_18735  aspartate racemase [KO:K25316] [EC:5.1.1.10]
AQ980_23610  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
AQ980_23615  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bthy00010  Glycolysis / Gluconeogenesis
bthy00020  Citrate cycle (TCA cycle)
bthy00230  Purine metabolism
bthy00250  Alanine, aspartate and glutamate metabolism
bthy00270  Cysteine and methionine metabolism
bthy00290  Valine, leucine and isoleucine biosynthesis
bthy00300  Lysine biosynthesis
bthy00330  Arginine and proline metabolism
bthy00460  Cyanoamino acid metabolism
bthy00470  D-Amino acid metabolism
bthy00564  Glycerophospholipid metabolism
bthy00620  Pyruvate metabolism
bthy00630  Glyoxylate and dicarboxylate metabolism
bthy00640  Propanoate metabolism
bthy00680  Methane metabolism
bthy00860  Porphyrin metabolism
bthy00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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