KEGG   PATHWAY: cdet04146
Entry
cdet04146                   Pathway                                
Name
Peroxisome - Colletotrichum destructivum
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
cdet04146  Peroxisome
cdet04146

Other DBs
GO: 0005777
Organism
Colletotrichum destructivum [GN:cdet]
Gene
87936857  CDEST_00354; Putative FAD dependent oxidoreductase, FAD/NAD(P)-binding domain superfamily, MTOX family [KO:K00306] [EC:1.5.3.1 1.5.3.7]
87936969  CDEST_00466; Putative enoyl-CoA hydratase/isomerase, ClpP/crotonase-like domain superfamily [KO:K13239] [EC:5.3.3.8]
87937076  CDEST_00573; Putative peroxin-3 [KO:K13336]
87937166  CDEST_00663; Putative NUDIX hydrolase domain, NADH pyrophosphatase-like, Zinc ribbon, NADH pyrophosphatase [KO:K03426] [EC:3.6.1.22]
87937170  CDEST_00667; Putative catalase hem-binding, catalase immune-responsive domain, catalase core [KO:K03781] [EC:1.11.1.6]
87937313  CDEST_00810; Putative mitochondrial carrier protein [KO:K13354]
87937330  CDEST_00827; Putative mitochondrial carrier protein [KO:K13354]
87937875  CDEST_01372; Putative catalase hem-binding, catalase immune-responsive domain, catalase core [KO:K03781] [EC:1.11.1.6]
87938209  CDEST_01706; Putative catalase hem-binding, catalase immune-responsive domain, catalase core [KO:K03781] [EC:1.11.1.6]
87938927  CDEST_02424; Putative FAD dependent oxidoreductase, FAD/NAD(P)-binding domain superfamily, MTOX family [KO:K00306] [EC:1.5.3.1 1.5.3.7]
87939114  CDEST_02611; Putative AAA+ ATPase domain, ATPase, AAA-type, core, aspartate decarboxylase-like domain superfamily [KO:K13338]
87939439  CDEST_02936; Putative manganese/iron superoxide dismutase [KO:K04564] [EC:1.15.1.1]
87939560  CDEST_03057; Putative Zinc finger, RING-type, peroxisome biogenesis factor 2/10 [KO:K13346]
87939725  CDEST_03222; Putative AAA+ ATPase domain, ATPase, AAA-type, core [KO:K13339]
87940029  CDEST_03526; Putative redoxin [KO:K11187] [EC:1.11.1.24]
87940481  CDEST_03978; Putative alpha/beta hydrolase-1, epoxide hydrolase [KO:K08726] [EC:3.3.2.10 3.1.3.76]
87940721  CDEST_04218; Putative alpha/beta hydrolase-1, epoxide hydrolase [KO:K08726] [EC:3.3.2.10 3.1.3.76]
87941068  CDEST_04565; Putative ribosomal protein uS5 domain 2-type superfamily [KO:K00869] [EC:2.7.1.36]
87941571  CDEST_05068; Putative acyltransferase ChoActase/COT/CPT, choline/carnitine acyltransferase [KO:K00624] [EC:2.3.1.7]
87941687  CDEST_05184; Putative peroxisome assembly protein [KO:K13345]
87941802  CDEST_05299; Putative WD40/YVTN repeat-like-containing domain superfamily [KO:K13341]
87942351  CDEST_05848; Putative short-chain dehydrogenase/reductase SDR, NAD(P)-binding domain superfamily [KO:K13237] [EC:1.3.1.124]
87942404  CDEST_05901; Putative thiolase [KO:K07513] [EC:2.3.1.16]
87942480  CDEST_05977; Putative manganese/iron superoxide dismutase [KO:K04564] [EC:1.15.1.1]
87942714  CDEST_06211; Putative FMN-dependent dehydrogenase, FMN-dependent alpha-hydroxy acid dehydrogenase, active [KO:K11517] [EC:1.1.3.15]
87942831  CDEST_06328; Putative AMP-dependent synthetase/ligase domain, AMP-binding, ANL domain-containing protein [KO:K01897] [EC:6.2.1.3]
87942966  CDEST_06463; Putative aminotransferase class V domain, pyridoxal phosphate-dependent transferase, major [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
87943125  CDEST_06622; Putative acyltransferase ChoActase/COT/CPT, choline/carnitine acyltransferase [KO:K00624] [EC:2.3.1.7]
87943358  CDEST_06855; Putative mitochondrial carrier domain superfamily [KO:K13354]
87943467  CDEST_06964; Putative pyruvate carboxyltransferase, aldolase-type TIM barrel, HMG-CoA lyase [KO:K01640] [EC:4.1.3.4]
87943537  CDEST_07034; Putative thiolase [KO:K08764] [EC:2.3.1.176]
87943635  CDEST_07132; Putative FAD dependent oxidoreductase, FAD/NAD(P)-binding domain superfamily, MTOX family [KO:K00306] [EC:1.5.3.1 1.5.3.7]
87943654  CDEST_07151; Putative AAA+ ATPase domain, ABC transporter type 1, transmembrane domain-containing protein [KO:K15628] [EC:7.6.2.4]
87943785  CDEST_07282; Putative FAD dependent oxidoreductase, FAD/NAD(P)-binding domain superfamily, MTOX family [KO:K00306] [EC:1.5.3.1 1.5.3.7]
87943832  CDEST_07329; Putative CO dehydrogenase flavoprotein [KO:K00106] [EC:1.17.1.4 1.17.3.2]
87944361  CDEST_07858; Putative superoxide dismutase, copper/zinc binding domain-containing protein [KO:K04565] [EC:1.15.1.1]
87944866  CDEST_08363; Putative peroxisome membrane protein, Pex16 [KO:K13335]
87944928  CDEST_08425; Putative AMP-dependent synthetase/ligase domain, AMP-binding, ANL domain-containing protein [KO:K01897] [EC:6.2.1.3]
87945199  CDEST_08696; Putative phytanoyl-CoA dioxygenase [KO:K00477] [EC:1.14.11.18]
87945377  CDEST_08874; Putative AMP-dependent synthetase/ligase domain, AMP-binding, ANL domain-containing protein [KO:K01897] [EC:6.2.1.3]
87945553  CDEST_09050; Putative alpha/beta hydrolase-1, epoxide hydrolase [KO:K08726] [EC:3.3.2.10 3.1.3.76]
87946019  CDEST_09516; Putative acyl-CoA oxidase, acyl-CoA dehydrogenase/oxidase and middle domain superfamily [KO:K00232] [EC:1.3.3.6]
87946390  CDEST_09888; Putative tetratricopeptide-like helical domain superfamily [KO:K13342]
87946414  CDEST_09912; Putative peroxisomal membrane protein [KO:K13350]
87946538  CDEST_10036; Putative short-chain dehydrogenase/reductase SDR, NAD(P)-binding domain superfamily [KO:K13237] [EC:1.3.1.124]
87947162  CDEST_10662; Putative FAD dependent oxidoreductase, D-amino acid oxidase, D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
87947441  CDEST_10941; Putative catalase core domain, catalase, mono-functional, hem-containing, Catalase superfamily [KO:K03781] [EC:1.11.1.6]
87947628  CDEST_11128; Putative FAD dependent oxidoreductase, FAD/NAD(P)-binding domain superfamily, MTOX family [KO:K00306] [EC:1.5.3.1 1.5.3.7]
87947641  CDEST_11141; Putative thiolase [KO:K07513] [EC:2.3.1.16]
87947715  CDEST_11215; Putative peroxisomal membrane protein [KO:K13343]
87947727  CDEST_11227; Putative peroxisomal biogenesis factor 11 [KO:K13352]
87948041  CDEST_11541; Putative CoA-transferase family III [KO:K01796] [EC:5.1.99.4]
87948248  CDEST_11748; Putative thiolase [KO:K07513] [EC:2.3.1.16]
87948429  CDEST_11929; Putative FAD dependent oxidoreductase, D-amino acid oxidase, D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
87948672  CDEST_12172; Putative SH3 domain, peroxin 13, SH3-like domain superfamily [KO:K13344]
87948780  CDEST_12280; Putative peroxisome biogenesis factor 2/10 [KO:K06664]
87948863  CDEST_12363; Putative AAA+ ATPase domain, ABC transporter type 1, transmembrane domain-containing protein [KO:K15628] [EC:7.6.2.4]
87948877  CDEST_12377; Putative pyruvate carboxyltransferase, enoyl-CoA hydratase/isomerase, aldolase-type TIM barrel [KO:K01640] [EC:4.1.3.4]
87949025  CDEST_12525; uncharacterized protein [KO:K13348]
87949587  CDEST_13087; Putative FAD dependent oxidoreductase, FAD/NAD(P)-binding domain superfamily, MTOX family [KO:K00306] [EC:1.5.3.1 1.5.3.7]
87949988  CDEST_13488; Putative FMN-dependent dehydrogenase, FMN-dependent alpha-hydroxy acid dehydrogenase, active [KO:K11517] [EC:1.1.3.15]
87949998  CDEST_13498; Putative pex19 protein [KO:K13337]
87950009  CDEST_13509; Putative phytanoyl-CoA dioxygenase [KO:K00477] [EC:1.14.11.18]
87950015  CDEST_13515; Putative alpha/beta hydrolase-1, epoxide hydrolase [KO:K08726] [EC:3.3.2.10 3.1.3.76]
87950108  CDEST_13608; Putative enoyl-CoA hydratase/isomerase, ClpP/crotonase-like domain superfamily [KO:K12663] [EC:5.3.3.21]
87950124  CDEST_13624; Putative FAD dependent oxidoreductase, FAD/NAD(P)-binding domain superfamily, MTOX family [KO:K00306] [EC:1.5.3.1 1.5.3.7]
87950294  CDEST_13794; Putative isocitrate dehydrogenase NADP-dependent, isocitrate/isopropylmalate dehydrogenase [KO:K00031] [EC:1.1.1.42]
87951569  CDEST_15069; Putative manganese/iron superoxide dismutase [KO:K04564] [EC:1.15.1.1]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
cdet00071  Fatty acid degradation
cdet00230  Purine metabolism
cdet00564  Glycerophospholipid metabolism
cdet00565  Ether lipid metabolism
cdet00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   

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