KEGG PATHWAY: cfar00790

KEGG

PATHWAY: cfar00790

Entry

cfar00790                   Pathway

Name

Folate biosynthesis - Citrobacter farmeri

Class

Metabolism; Metabolism of cofactors and vitamins

Pathway map

Folate biosynthesis

Module

Tetrahydrofolate biosynthesis, GTP => THF [PATH:cfar00790]

Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:cfar00790]

Other DBs

GO:

Organism

Citrobacter farmeri [GN:cfar]

Gene

GTP cyclohydrolase I FolE [KO:K01495] [EC:3.5.4.16]

alkaline phosphatase [KO:K01077] [EC:3.1.3.1]

NUDIX pyrophosphatase [KO:K08310] [EC:3.6.1.67]

folB; bifunctional dihydroneopterin aldolase/7,8-dihydroneopterin epimerase [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [KO:K00950] [EC:2.7.6.3]

dihydropteroate synthase [KO:K00796] [EC:2.5.1.15]

sulfonamide-resistant dihydropteroate synthase Sul1 [KO:K18974] [EC:2.5.1.15]

sulfonamide-resistant dihydropteroate synthase Sul1 [KO:K18974] [EC:2.5.1.15]

sulfonamide-resistant dihydropteroate synthase Sul1 [KO:K18974] [EC:2.5.1.15]

sulfonamide-resistant dihydropteroate synthase Sul1 [KO:K18974] [EC:2.5.1.15]

sulfonamide-resistant dihydropteroate synthase Sul1 [KO:K18974] [EC:2.5.1.15]

folP; sulfonamide-resistant dihydropteroate synthase Sul2 [KO:K18824] [EC:2.5.1.15]

folA; type 3 dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]

trimethoprim-resistant dihydrofolate reductase DfrA19 [KO:K19644] [EC:1.5.1.3]

bifunctional tetrahydrofolate synthase/dihydrofolate synthase [KO:K11754] [EC:6.3.2.12 6.3.2.17]

ribA; GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]

aminodeoxychorismate synthase component 2 [KO:K01664] [EC:2.6.1.85]

pabB; aminodeoxychorismate synthase component 1 [KO:K01665] [EC:2.6.1.85]

aminodeoxychorismate lyase [KO:K02619] [EC:4.1.3.38]

dihydroneopterin triphosphate 2'-epimerase [KO:K07589] [EC:5.1.99.7]

dihydromonapterin reductase [KO:K13938] [EC:1.5.1.50 1.5.1.3]

queD; 6-carboxytetrahydropterin synthase QueD [KO:K01737] [EC:4.2.3.12 4.1.2.50]

queD; 6-carboxytetrahydropterin synthase QueD [KO:K01737] [EC:4.2.3.12 4.1.2.50]

7-carboxy-7-deazaguanine synthase [KO:K10026] [EC:4.3.99.3]

7-cyano-7-deazaguanine synthase [KO:K06920] [EC:6.3.4.20]

preQ(1) synthase [KO:K06879] [EC:1.7.1.13]

MBL fold metallo-hydrolase [KO:K06897] [EC:2.5.1.105]

GTP 3',8-cyclase MoaA [KO:K03639] [EC:4.1.99.22]

moaC; cyclic pyranopterin monophosphate synthase MoaC [KO:K03637] [EC:4.6.1.17]

moaE; molybdopterin synthase catalytic subunit MoaE [KO:K03635] [EC:2.8.1.12]

molybdopterin adenylyltransferase [KO:K03831] [EC:2.7.7.75]

moaB; molybdenum cofactor biosynthesis protein [KO:K03638] [EC:2.7.7.75]

molybdopterin molybdenumtransferase MoeA [KO:K03750] [EC:2.10.1.1]

mocA; molybdenum cofactor cytidylyltransferase [KO:K07141] [EC:2.7.7.76]

mobA; molybdenum cofactor guanylyltransferase MobA [KO:K03752] [EC:2.7.7.77]

Compound

GTP

Tetrahydrofolate

5-Phospho-alpha-D-ribose 1-diphosphate

4-Hydroxybenzoate

Chorismate

Glycolaldehyde

Dihydrobiopterin

Tetrahydrobiopterin

Dihydrofolate

Folate

4-Aminobenzoate

Sepiapterin

Dihydropteroate

5,6,7,8-Tetrahydromethanopterin

6-(Hydroxymethyl)-7,8-dihydropterin

2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one

Pyrimidodiazepine

7,8-Dihydrobiopterin

THF-polyglutamate

6-Pyruvoyltetrahydropterin

6-Lactoyl-5,6,7,8-tetrahydropterin

6-Hydroxymethyl-7,8-dihydropterin diphosphate

7,8-Dihydroneopterin

7,8-Dihydroneopterin 3'-triphosphate

Formamidopyrimidine nucleoside triphosphate

2,5-Diaminopyrimidine nucleoside triphosphate

Molybdopterin

Dihydroneopterin phosphate

Neopterin

7,8-Dihydromethanopterin

2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine

Biopterin

THF-L-glutamate

4-Amino-4-deoxychorismate

4a-Hydroxytetrahydrobiopterin

7-Cyano-7-carbaguanine

7-Aminomethyl-7-carbaguanine

Molybdoenzyme molybdenum cofactor

Precursor Z

Tetrahydrosarcinapterin

Adenylated molybdopterin

Guanylyl molybdenum cofactor

6-Carboxy-5,6,7,8-tetrahydropterin

7-Carboxy-7-carbaguanine

L-threo-Tetrahydrobiopterin

4-(beta-D-Ribofuranosyl)aniline 5'-phosphate

N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate

7,8-Dihydroneopterin 2'-phosphate

7,8-Dihydroneopterin 2',3'-cyclic phosphate

5,6,7,8-Tetrahydromonapterin

7,8-Dihydromonapterin

7,8-Dihydroxanthopterin

7,8-Dihydromonapterin 3'-triphosphate

4-(beta-D-Ribofuranosyl)phenol 5'-phosphate

(8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate

Cytidylyl molybdenum cofactor

Thio-molybdenum cofactor

6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

Authors

Schwarz G, Mendel RR, Ribbe MW

Title

Molybdenum cofactors, enzymes and pathways.

Journal

Nature 460:839-47 (2009)
DOI:10.1038/nature08302

Reference

Authors

Hanzelmann P, Schindelin H

Title

Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.

Journal

Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103

Reference

Authors

Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H

Title

Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.

Journal

Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g

Reference

Authors

Wuebbens MM, Rajagopalan KV

Title

Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.

Journal

J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200

Reference

Authors

Werner ER, Blau N, Thony B

Title

Tetrahydrobiopterin: biochemistry and pathophysiology.

Journal

Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293

Reference

Authors

Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A

Title

Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.

Journal

Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9

Reference

Authors

Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N

Title

Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.

Journal

Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P

Related
pathway

Purine metabolism

Benzoate degradation

Phenylalanine, tyrosine and tryptophan biosynthesis

One carbon pool by folate

Methane metabolism

KO pathway

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