PATHWAY: cgib00020 Help
Entry
Name
Citrate cycle (TCA cycle) - Carassius gibelio (silver crucian carp)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:
M00009 ], but contain genes for specific segments [MD:
M00010 M00011 ].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Ortholog table
Module
Other DBs
Organism
Carassius gibelio (silver crucian carp) [GN:
cgib ]
Gene
127933208 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658 ] [EC:2.3.1.61 ]
127975807 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
127944258 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
128011999 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
127951659 succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236 ]
127935063 succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236 ]
127972917 succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial isoform X1 [KO:K00237 ]
128031586 succinate dehydrogenase [ubiquinone] cytochrome b small subunit A, mitochondrial [KO:K00237 ]
128029455 succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial-like [KO:K00237 ]
127957507 pyruvate dehydrogenase E1 component subunit alpha, mitochondrial-like isoform X1 [KO:K00161 ] [EC:1.2.4.1 ]
128011414 pyruvate dehydrogenase E1 component subunit alpha, mitochondrial-like isoform X1 [KO:K00161 ] [EC:1.2.4.1 ]
127986950 pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like isoform X1 [KO:K00162 ] [EC:1.2.4.1 ]
127986951 pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like isoform X1 [KO:K00162 ] [EC:1.2.4.1 ]
127941921 dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
128015019 dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
127986426 dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial [KO:K00627 ] [EC:2.3.1.12 ]
Compound
C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate
C05381 3-Carboxy-1-hydroxypropyl-ThPP
C15972 Enzyme N6-(lipoyl)lysine
C15973 Enzyme N6-(dihydrolipoyl)lysine
C16254 [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
Authors
Nishizuka Y (ed).
Title
[Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1980)
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Michal G.
Title
Biochemical Pathways
Journal
Wiley (1999)
Related pathway
cgib00250 Alanine, aspartate and glutamate metabolism
cgib00280 Valine, leucine and isoleucine degradation
cgib00630 Glyoxylate and dicarboxylate metabolism
KO pathway
LinkDB
All DBs