KEGG   PATHWAY: cic00480
Entry
cic00480                    Pathway                                
Name
Glutathione metabolism - Citrus x clementina (clementine)
Class
Metabolism; Metabolism of other amino acids
Pathway map
cic00480  Glutathione metabolism
cic00480

Module
cic_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:cic00480]
Other DBs
GO: 0006749
Organism
Citrus x clementina (clementine) [GN:cic]
Gene
CICLE_v10007745mg  hypothetical protein [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
CICLE_v10007750mg  hypothetical protein [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
CICLE_v10025225mg  hypothetical protein [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
CICLE_v10002572mg  hypothetical protein [KO:K22596] [EC:4.3.2.9]
CICLE_v10009681mg  hypothetical protein [KO:K22596] [EC:4.3.2.9]
CICLE_v10018533mg  hypothetical protein [KO:K01469] [EC:3.5.2.9]
CICLE_v10019696mg  hypothetical protein [KO:K01919] [EC:6.3.2.2]
CICLE_v10000728mg  hypothetical protein [KO:K21456] [EC:6.3.2.3]
CICLE_v10007834mg  hypothetical protein [KO:K01255] [EC:3.4.11.1]
CICLE_v10018808mg  hypothetical protein [KO:K01256] [EC:3.4.11.2]
CICLE_v10024097mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10002406mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10032680mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10005808mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10010875mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v100058402m  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10005812mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10005809mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10006671mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10005779mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10005771mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10022160mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10024356mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10022212mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10033001mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10032743mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10032737mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10024585mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10029241mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10030408mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10033464mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10002423mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10006863mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10005833mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10005835mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10005829mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10005850mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10005837mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10006426mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10006981mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10005843mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10006532mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10005851mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10006776mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10012511mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10012621mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10012631mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10023959mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10022164mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10022193mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10022154mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10002678mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10003982mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10002119mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10006901mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10005841mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10006966mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10032696mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10032702mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10032686mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10033916mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10012710mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10012717mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10013005mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10012739mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10033796mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10033718mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10033417mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10033587mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10021879mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10021831mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10033632mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10006556mg  hypothetical protein [KO:K00799] [EC:2.5.1.18]
CICLE_v10012501mg  hypothetical protein [KO:K21888] [EC:1.8.5.1 2.5.1.18]
CICLE_v10004819mg  hypothetical protein [KO:K00383] [EC:1.8.1.7]
CICLE_v10019567mg  hypothetical protein [KO:K00383] [EC:1.8.1.7]
CICLE_v100148161m  hypothetical protein [KO:K00031] [EC:1.1.1.42]
CICLE_v10001314mg  hypothetical protein [KO:K00031] [EC:1.1.1.42]
CICLE_v10005058mg  hypothetical protein [KO:K00031] [EC:1.1.1.42]
CICLE_v10011597mg  hypothetical protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
CICLE_v10019859mg  hypothetical protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
CICLE_v10024185mg  hypothetical protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
CICLE_v10023851mg  hypothetical protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
CICLE_v10031373mg  hypothetical protein [KO:K00033] [EC:1.1.1.44 1.1.1.343]
CICLE_v10015153mg  hypothetical protein [KO:K00036] [EC:1.1.1.49 1.1.1.363]
CICLE_v10009304mg  hypothetical protein [KO:K00432] [EC:1.11.1.9]
CICLE_v10022293mg  hypothetical protein [KO:K00432] [EC:1.11.1.9]
CICLE_v10022566mg  hypothetical protein [KO:K00432] [EC:1.11.1.9]
CICLE_v10022569mg  hypothetical protein [KO:K00432] [EC:1.11.1.9]
CICLE_v10007138mg  hypothetical protein [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
CICLE_v10031824mg  hypothetical protein [KO:K01581] [EC:4.1.1.17]
CICLE_v10020253mg  hypothetical protein [KO:K01581] [EC:4.1.1.17]
CICLE_v10024359mg  hypothetical protein [KO:K00797] [EC:2.5.1.16]
CICLE_v10006705mg  hypothetical protein [KO:K00797] [EC:2.5.1.16]
CICLE_v10031988mg  hypothetical protein [KO:K00797] [EC:2.5.1.16]
CICLE_v10028990mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
CICLE_v10030198mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
CICLE_v10008868mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
CICLE_v10012554mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
CICLE_v10026205mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
CICLE_v10001194mg  hypothetical protein [KO:K00434] [EC:1.11.1.11]
CICLE_v10000379mg  hypothetical protein [KO:K10807] [EC:1.17.4.1]
CICLE_v10027252mg  hypothetical protein [KO:K10807] [EC:1.17.4.1]
CICLE_v10030727mg  hypothetical protein [KO:K10807] [EC:1.17.4.1]
CICLE_v10005323mg  hypothetical protein [KO:K10808] [EC:1.17.4.1]
CICLE_v10026060mg  hypothetical protein [KO:K10808] [EC:1.17.4.1]
CICLE_v10032088mg  hypothetical protein [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
cic00220  Arginine biosynthesis
cic00250  Alanine, aspartate and glutamate metabolism
cic00270  Cysteine and methionine metabolism
cic00430  Taurine and hypotaurine metabolism
cic00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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