KEGG   PATHWAY: clus00260
Entry
clus00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Clavispora lusitaniae CBS 6936
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
clus00260  Glycine, serine and threonine metabolism
clus00260

Module
clus_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:clus00260]
clus_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:clus00260]
clus_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:clus00260]
clus_M00621  Glycine cleavage system [PATH:clus00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Clavispora lusitaniae CBS 6936 [GN:clus]
Gene
A9F13_25g00759  putative aspartokinase [KO:K00928] [EC:2.7.2.4]
A9F13_20g00649  putative aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
A9F13_13g00418  putative homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
A9F13_03g02981  putative homoserine kinase [KO:K00872] [EC:2.7.1.39]
A9F13_01g09009  putative threonine synthase [KO:K01733] [EC:4.2.3.1]
A9F13_14g00528  putative low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
A9F13_03g02673  putative threonine aldolase [KO:K01620] [EC:4.1.2.48]
A9F13_02g01903  putative serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
A9F13_18g00891  putative serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
A9F13_16g00638  putative alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
A9F13_02g04125  putative phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
A9F13_06g02123  putative phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
A9F13_03g01419  putative phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
A9F13_08g01166  putative phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
A9F13_04g03773  putative ATP-dependent kinase [KO:K15918] [EC:2.7.1.31]
A9F13_01g02849  putative phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
A9F13_11g02387  putative phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
A9F13_25g00385  putative phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
A9F13_02g01826  putative oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
A9F13_01g04851  putative 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
A9F13_10g00308  putative amine oxidase [KO:K00276] [EC:1.4.3.21]
A9F13_05g01507  putative amine oxidase [KO:K00276] [EC:1.4.3.21]
A9F13_29g00352  putative glycine decarboxylase subunit [KO:K00281] [EC:1.4.4.2]
A9F13_01g03454  putative aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
A9F13_13g01309  putative dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
A9F13_01g09581  putative glycine decarboxylase subunit [KO:K02437]
A9F13_07g03487  putative D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
A9F13_20g00220  putative D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
A9F13_24g00319  putative D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
A9F13_07g01287  putative CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
A9F13_19g00429  putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
A9F13_07g00462  putative cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
A9F13_11g02365  putative threonine dehydratase [KO:K01754] [EC:4.3.1.19]
A9F13_26g00385  putative catabolic L-serine/threonine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
A9F13_06g00418  putative L-serine/L-threonine ammonia-lyase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
A9F13_06g01903  putative tryptophan synthase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
clus00010  Glycolysis / Gluconeogenesis
clus00020  Citrate cycle (TCA cycle)
clus00230  Purine metabolism
clus00250  Alanine, aspartate and glutamate metabolism
clus00270  Cysteine and methionine metabolism
clus00290  Valine, leucine and isoleucine biosynthesis
clus00300  Lysine biosynthesis
clus00330  Arginine and proline metabolism
clus00460  Cyanoamino acid metabolism
clus00470  D-Amino acid metabolism
clus00564  Glycerophospholipid metabolism
clus00600  Sphingolipid metabolism
clus00620  Pyruvate metabolism
clus00630  Glyoxylate and dicarboxylate metabolism
clus00640  Propanoate metabolism
clus00680  Methane metabolism
clus00860  Porphyrin metabolism
clus00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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