KEGG   PATHWAY: cmk00053
Entry
cmk00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Callorhinchus milii (elephant shark)
Class
Metabolism; Carbohydrate metabolism
Pathway map
cmk00053  Ascorbate and aldarate metabolism
cmk00053

Module
cmk_M00129  Ascorbate biosynthesis, animals, glucose-1P => ascorbate [PATH:cmk00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Callorhinchus milii (elephant shark) [GN:cmk]
Gene
103175860  ugdh; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
103184107  UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
103190789  gkup; glucuronokinase with putative uridyl pyrophosphorylase [KO:K16190] [EC:2.7.1.43]
103176853  UDP-glucuronosyltransferase 1A1 isoform X1 [KO:K00699] [EC:2.4.1.17]
103171722  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
103180625  gusb; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
103177202  kl; klotho [KO:K14756] [EC:3.2.1.31]
103190008  miox; inositol oxygenase [KO:K00469] [EC:1.13.99.1]
103176872  akr1a1a; aldo-keto reductase family 1 member A1-A [KO:K00002] [EC:1.1.1.2]
103182771  akr1a1b; aldo-keto reductase family 1 member A1-B [KO:K00002] [EC:1.1.1.2]
103177110  rgn; regucalcin [KO:K01053] [EC:3.1.1.17]
103191462  L-gulonolactone oxidase [KO:K00103] [EC:1.1.3.8]
103189441  aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
103186924  aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00128] [EC:1.2.1.3]
103184053  aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
103182361  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
103180031  aldh9a1a.1; 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
cmk00020  Citrate cycle (TCA cycle)
cmk00040  Pentose and glucuronate interconversions
cmk00051  Fructose and mannose metabolism
cmk00520  Amino sugar and nucleotide sugar metabolism
cmk00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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