KEGG   PATHWAY: cnc00630
Entry
cnc00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Cupriavidus necator N-1
Class
Metabolism; Carbohydrate metabolism
Pathway map
cnc00630  Glyoxylate and dicarboxylate metabolism
cnc00630

Module
cnc_M00012  Glyoxylate cycle [PATH:cnc00630]
cnc_M00621  Glycine cleavage system [PATH:cnc00630]
Other DBs
GO: 0046487 0043648
Organism
Cupriavidus necator N-1 [GN:cnc]
Gene
CNE_1c21150  iclA; isocitrate lyase IclA [KO:K01637] [EC:4.1.3.1]
CNE_1c21320  aceA; isocitrate lyase AceA [KO:K01637] [EC:4.1.3.1]
CNE_1c16240  acsA1; acetyl-coenzyme A synthetase AcsA [KO:K01895] [EC:6.2.1.1]
CNE_1c11450  acyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
CNE_1c24100  acsA3; acetyl-coenzyme A synthetase AcsA [KO:K01895] [EC:6.2.1.1]
CNE_1c17260  acsA2; acetyl-coenzyme A synthetase AcsA [KO:K01895] [EC:6.2.1.1]
CNE_2c10630  acsA; acetyl-coenzyme A synthetase AcsA [KO:K01895] [EC:6.2.1.1]
CNE_BB1p02590  acsA1; acetyl-coenzyme A synthetase AcsA [KO:K01895] [EC:6.2.1.1]
CNE_BB1p04480  acsA2; acetyl-coenzyme A synthetase AcsA [KO:K01895] [EC:6.2.1.1]
CNE_1c21260  aceB; malate synthase AceB [KO:K01638] [EC:2.3.3.9]
CNE_1c25170  mdh; malate dehydrogenase Mdh [KO:K00024] [EC:1.1.1.37]
CNE_BB2p02420  hypothetical protein [KO:K01647] [EC:2.3.3.1]
CNE_1c16890  citrate synthase [KO:K01647] [EC:2.3.3.1]
CNE_1c25100  gltA; citrate synthase GltA [KO:K01647] [EC:2.3.3.1]
CNE_BB2p00170  hypothetical protein [KO:K01647] [EC:2.3.3.1]
CNE_BB2p00460  citA; citrate synthase CitA [KO:K01647] [EC:2.3.3.1]
CNE_BB1p05490  citrate synthase [KO:K01647] [EC:2.3.3.1]
CNE_2c21900  citrate synthase [KO:K01647] [EC:2.3.3.1]
CNE_BB1p00230  citrate synthase [KO:K01647] [EC:2.3.3.1]
CNE_BB2p01580  acnA; aconitate hydratase AcnA [KO:K01681] [EC:4.2.1.3]
CNE_1c25210  acn; aconitate hydratase Acn [KO:K01681] [EC:4.2.1.3]
CNE_BB1p05470  acnA; aconitate hydratase AcnA [KO:K01681] [EC:4.2.1.3]
CNE_2c05150  acnB; aconitate hydratase AcnB [KO:K01682] [EC:4.2.1.3 4.2.1.99]
CNE_BB2p01480  fadA; 3-ketoacyl-CoA thiolase FadA [KO:K00626] [EC:2.3.1.9]
CNE_1c01610  thlA; acetyl-CoA acetyltransferase ThlA [KO:K00626] [EC:2.3.1.9]
CNE_1c14660  phaA1; acetyl-CoA acetyltransferase PhaA [KO:K00626] [EC:2.3.1.9]
CNE_1c15600  fadA2; 3-ketoacyl-CoA thiolase FadA [KO:K00626] [EC:2.3.1.9]
CNE_1c14710  bktB; acetyl-CoA acetyltransferase BktB [KO:K00626] [EC:2.3.1.9]
CNE_2c07060  fadA2; 3-ketoacyl-CoA thiolase FadA [KO:K00626] [EC:2.3.1.9]
CNE_1c12900  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
CNE_2c06090  pcaF2; beta-ketoadipyl-CoA thiolase PcaF [KO:K00626] [EC:2.3.1.9]
CNE_2c06150  fadA1; 3-ketoacyl-CoA thiolase FadA [KO:K00626] [EC:2.3.1.9]
CNE_2c13280  phaA; acetyl-CoA acetyltransferase PhaA [KO:K00626] [EC:2.3.1.9]
CNE_BB1p08600  fadA2; 3-ketoacyl-CoA thiolase FadA [KO:K00626] [EC:2.3.1.9]
CNE_BB1p02570  thlA; acetyl-CoA acetyltransferase ThlA [KO:K00626] [EC:2.3.1.9]
CNE_BB1p03780  propanoyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
CNE_BB1p05180  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
CNE_BB1p05190  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
CNE_BB1p05870  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
CNE_BB1p09260  fadA4; 3-ketoacyl-CoA thiolase FadA [KO:K00626] [EC:2.3.1.9]
CNE_BB2p01320  thlA; acetyl-CoA acetyltransferase ThlA [KO:K00626] [EC:2.3.1.9]
CNE_BB1p11060  phaA; acetyl-CoA acetyltransferase PhaA [KO:K00626] [EC:2.3.1.9]
CNE_BB1p11190  acetyl-CoA acetyltransferase (thiolase) [KO:K00626] [EC:2.3.1.9]
CNE_BB1p04700  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
CNE_1c14670  phaB1; acetoacetyl-CoA reductase PhaB [KO:K00023] [EC:1.1.1.36]
CNE_1c20870  fabG6; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00023] [EC:1.1.1.36]
CNE_BB1p07810  phbB; acetoacetyl-CoA reductase PhbB [KO:K00023] [EC:1.1.1.36]
CNE_BB1p10140  mcl; malyl-CoA lyase Mcl [KO:K08691] [EC:4.1.3.24 4.1.3.25]
CNE_BB1p08970  pycA; pyruvate carboxylase subunit A [KO:K01965] [EC:6.4.1.3]
CNE_2c17010  bccA; acetyl-/propionyl-coenzyme A carboxylase alpha subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
CNE_1c19190  bhbA; methylmalonyl-CoA mutase BhbA [KO:K01847] [EC:5.4.99.2]
CNE_1c30500  glcD3; glycolate oxidase subunit GlcD [KO:K00104] [EC:1.1.99.14]
CNE_1c30520  glcE; 2-hydroxy-acid oxidase, FAD-binding subunit [KO:K11472] [EC:1.1.99.14]
CNE_1c30530  glcF; 2-hydroxy-acid oxidase, Fe-S subunit [KO:K11473] [EC:1.1.99.14]
CNE_1c30660  katA; catalase KatA [KO:K03781] [EC:1.11.1.6]
CNE_1c01760  ghrA; glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CNE_1c17470  serA1; D-3-phosphoglycerate dehydrogenase SerA [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CNE_2c08040  serA3; D-3-phosphoglycerate dehydrogenase SerA [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CNE_1c24690  gyaR2; glyoxylate reductase GyaR [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
CNE_BB1p10160  hprA; glycerate dehydrogenase HprA [KO:K00018] [EC:1.1.1.29]
CNE_2c05540  hprA; glycerate dehydrogenase HprA [KO:K00018] [EC:1.1.1.29]
CNE_1c32550  gph3; phosphoglycolate phosphatase Gph [KO:K01091] [EC:3.1.3.18]
CNE_1c24610  phosphatase [KO:K01091] [EC:3.1.3.18]
CNE_2c13450  cbbZ; phosphoglycolate phosphatase CbbZ [KO:K01091] [EC:3.1.3.18]
CNE_2c13530  cbbL; ribulose bisphosphate carboxylase large subunit [KO:K01601] [EC:4.1.1.39]
CNE_2c13520  cbbS; ribulose bisphosphate carboxylase small subunit [KO:K01602] [EC:4.1.1.39]
CNE_2c11310  sgaA; serine--glyoxylate aminotransferase SgaA [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
CNE_2c05650  glnA; glutamine synthetase 1 [KO:K01915] [EC:6.3.1.2]
CNE_1c27380  glyA; serine hydroxymethyltransferase GlyA [KO:K00600] [EC:2.1.2.1]
CNE_1c35720  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
CNE_1c35700  gcvT2; aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
CNE_1c14040  pdhL; dihydrolipoamide dehydrogenase PdhL [KO:K00382] [EC:1.8.1.4]
CNE_2c10580  pdhD; dihydrolipoyl dehydrogenase PdhD [KO:K00382] [EC:1.8.1.4]
CNE_1c22330  odhL; dihydrolipoyl dehydrogenase OdhL [KO:K00382] [EC:1.8.1.4]
CNE_1c35710  gcvH; glycine cleavage system H protein GcvH [KO:K02437]
CNE_1c35470  gcl; glyoxylate carboligase Gcl [KO:K01608] [EC:4.1.1.47]
CNE_1c35480  hyi; hydroxypyruvate isomerase Hyi [KO:K01816] [EC:5.3.1.22]
CNE_1c35490  glxR2; 2-hydroxy-3-oxopropionate reductase GlxR [KO:K00042] [EC:1.1.1.60]
CNE_2c09090  glxR; 2-hydroxy-3-oxopropionate reductase GlxR [KO:K00042] [EC:1.1.1.60]
CNE_1c29540  glxR1; 2-hydroxy-3-oxopropionate reductase GlxR [KO:K00042] [EC:1.1.1.60]
CNE_2c05560  glxK2; glycerate kinase GlxK [KO:K00865] [EC:2.7.1.165]
CNE_BB1p10190  glxK; glycerate kinase GlxK [KO:K00865] [EC:2.7.1.165]
CNE_1c35500  ttuD3; hydroxypyruvate reductase TtuD [KO:K11529] [EC:2.7.1.165]
CNE_1c20650  ttuD2; hydroxypyruvate reductase TtuD [KO:K11529] [EC:2.7.1.165]
CNE_1c05000  ttuD1; hydroxypyruvate reductase TtuD [KO:K11529] [EC:2.7.1.165]
CNE_BB1p00490  fumarate hydratase subunit alpha [KO:K03779] [EC:4.2.1.32]
CNE_BB1p00500  fumA; fumarate hydratase class I, aerobic [KO:K03780] [EC:4.2.1.32]
CNE_1c04990  leuB1; 3-isopropylmalate dehydrogenase LeuB [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
CNE_1c20670  leuB2; 3-isopropylmalate dehydrogenase LeuB [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
CNE_1c17150  dmlA; D-malate dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
CNE_2c11840  eda; 2-keto-3-deoxygluconate 6-phosphate aldolase; 2-keto-4-hydroxyglutarate aldolase/oxaloacetate decarboxylase Eda [KO:K01625] [EC:4.1.2.14 4.1.3.42]
CNE_2c09190  fdh; formate dehydrogenase Fdh [KO:K00122] [EC:1.17.1.9]
CNE_1c06510  fdsD; NAD-dependent formate dehydrogenase delta subunit [KO:K00126] [EC:1.17.1.9]
CNE_1c06490  fdsA; NAD-dependent formate dehydrogenase alpha subunit [KO:K00123] [EC:1.17.1.9]
CNE_1c28860  fdhA; formate dehydrogenase alpha subunit [KO:K00123] [EC:1.17.1.9]
CNE_2c16760  fdwA; tungsten-containing formate dehydrogenase alpha subunit [KO:K00123] [EC:1.17.1.9]
CNE_2c16770  fdwB; tungsten-containing formate dehydrogenase beta subunit [KO:K22515] [EC:1.17.1.9]
CNE_2c14350  fdoH; formate dehydrogenase beta subunit [KO:K00124]
CNE_1c28850  fdhB; formate dehydrogenase iron-sulfur subunit [KO:K00124]
CNE_1c06480  fdsB; NAD-dependent formate dehydrogenase beta subunit [KO:K00124]
CNE_1c06470  fdsG; NAD-dependent formate dehydrogenase gamma subunit [KO:K00127]
CNE_1c28830  fdhC; cytochrome b subunit of formate dehydrogenase FdhC [KO:K00127]
CNE_2c14360  fdoI; formate dehydrogenase gamma subunit [KO:K00127]
CNE_1c29550  aylformamidase [KO:K01432] [EC:3.5.1.9]
CNE_1c27140  kynB; kynurenine formamidase KynB [KO:K07130] [EC:3.5.1.9]
CNE_1c23900  purU; formyltetrahydrofolate deformylase PurU [KO:K01433] [EC:3.5.1.10]
CNE_2c19190  purU; formyltetrahydrofolate deformylase PurU [KO:K01433] [EC:3.5.1.10]
CNE_1c29670  hutG3; N-formylglutamate amidohydrolase HutG [KO:K01458] [EC:3.5.1.68]
CNE_2c16870  oxc; oxalyl-CoA decarboxylase Oxc [KO:K01577] [EC:4.1.1.8]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
cnc00010  Glycolysis / Gluconeogenesis
cnc00020  Citrate cycle (TCA cycle)
cnc00030  Pentose phosphate pathway
cnc00053  Ascorbate and aldarate metabolism
cnc00071  Fatty acid degradation
cnc00230  Purine metabolism
cnc00250  Alanine, aspartate and glutamate metabolism
cnc00260  Glycine, serine and threonine metabolism
cnc00620  Pyruvate metabolism
cnc00710  Carbon fixation in photosynthetic organisms
cnc00750  Vitamin B6 metabolism
cnc00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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